Assessment of motor activity in regulatory neurotoxicity studies: Validation of the ethovision video tracking system in rats treated with amphetamine and chlorpromazine

Toxicology Methods

Volumn 7, Issue 4, 1997, Pages 279-287

  Healing, Guy ^a   Harvey, Philip W ^b   McFarlane, Mary ^b   Buss, Nicholas A P S ^b   Mallyon, Brian A ^b   Cockburn, Andrew ^b  

^a ASTRAZENECA   (United Kingdom)

^b AgrEvo UK Limited   (United Kingdom)

Author keywords

Amphetamine; Chlorpromazine; Ethovision video tracking; Motor activity; Neurotoxicity; Rat

Indexed keywords

EID: 0039650222     PISSN: 10517235     EISSN: None     Source Type: Journal    
DOI: 10.1080/105172397243060     Document Type: Article

References (12)

1. U.S. Environmental Protection Agency Pesticide Assessment Guidelines, subdivision F, Hazard Evaluation: Human and Domestic Animals. November 1984: Addendum 10, Neurotoxicity series 81, 82, and 83.
2. OECD Guidelines for Testing of Chemicals, section 4: Health Effects.
3. Crofton KM, Howard JL, Moser VC, Gill MW, Reiter LW, Tilson HA, Macphail RC. Interlaboratory comparison of motor activity experiments: implications for neurotoxicological assessment. Neurotoxicol Teratol. 1991; 13:599-609.
4. Sanberg PR. Locomotor behaviour: neuropharmacological substrates of motor activation. Proceedings of satellite symposium 15th Annual Meeting of Society of Neuroscience. Pharmacol Biochem. 1986;25:229-300.
5. Tryon WW (ed). Behavioral Assessment in Behavioral Medicine. New York: Springer; 1985.
6. Bonatz AE, Steiner H, Huston JP. Video image analysis of behavior by microcomputer: categorization of turning and locomotion after 6-OHDA injection into the substantia nigra. J Neurosci Methods. 1987;22:13-26.
7. Mize RR, Holdefer RN, Nabors LB. Quantitative immunocytochemistry using an image analyser, 1: hardware evaluation, image processing and data analysis. J Neurosci Methods. 1988;26:1-24.
8. Claro F, Del Abril A, Segovia S. A computer program to record and analyse sexual behavior in rodents. Physiol Behav. 1990;48:489-493.
9. Winberg S, Nilsson GE, Spruijt BM, Hoglund U. Spontaneous locomotor activity in arctic charr measured by a computerized imaging technique: role of brain serotonergic activity. J Exp Biol. 1993;179:213-232.
10. Nilsson GE, Rosen P, Johansson D. Anoxic depression of spontaneous locomotor activity in crucian carp quantified by a computerized imaging technique. J Exp Biol. 1993;180:153-162.
11. Spruijt BM, Hol T, Rousseau J. Approach, avoidance and contact behavior of individually recognized animals automatically quantified with an imaging technique. Physiol Behav. 1992;51:747-752.
12. Mann HB, Whitney DR. On a test of whether one of two random variables is stochastically larger than the other. Ann Math Statist. 1947;18:50-60.