Randomized, prospective, controlled study comparing radical prostatectomy alone and neoadjuvant androgen withdrawal in the treatment of localized prostate cancer

Journal of Urology

Volumn 156, Issue 3, 1996, Pages 873-877

  Goldenberg, S Larry ^a   Klotz, Laurence H ^a   Srigley, John ^a   Jewett, Michael A S ^a   Mador, David ^a   Fradet, Yves ^a   Barkin, Jack ^a   Chin, Joseph ^a   Paquin, Jean Marie ^a   Bullock, Martin J ^a   Laplante, Suzanne ^a   Sullivan, L D ^b   Gleave, M E ^b   McLoughlin, M G ^b   Prestage, K ^b   Kinahan, T J ^b   Orovan, W L ^b   Whelan, J P ^b   Herschorn, S ^b   Keresteci, A G ^b   Robinette, M ^b   Bruce, A ^b   Stewart, D A ^b   Ruether, J D ^b   Ernst, D S ^b   Chetner, M ^b   Metcalfe, J B ^b   Elhilali, M ^b   Aprikian, A G ^b   Bertrand, P E ^b   Schick, E ^b   Tessier, J ^b   Halsall, A K ^b   Weckworth, P F ^b   more..

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NONE

Author keywords

androgens; cyproterone acetate; prostatectomy; prostatic neoplasms

Indexed keywords

ANDROGEN; ANTICOAGULANT AGENT; CYPROTERONE ACETATE; HEPARIN;

ADULT; AGED; ARTICLE; ASTHENIA; CANCER ADJUVANT THERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DEPRESSION; DRUG EFFICACY; DYSPNEA; HOT FLUSH; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; PROSTATECTOMY; RANDOMIZED CONTROLLED TRIAL; THROMBOEMBOLISM; TREATMENT OUTCOME;

EID: 0039614440     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)65645-3     Document Type: Article

References (24)

1. Rosen, M. A., Goldstone, L., Lapin, S., Wheeler, T. and Scardino, P. T.: Frequency and location of extracapsular extension and positive surgical margins in radical prostatectomy specimens. J. Urol., 148: 331, 1992.
2. Lange, P. H. and Narayan, P.: Understaging and undergrading of prostate cancer. Argument for postoperative radiation as adjuvant treatment. Urology, 21: 113, 1983.
3. Bigg, S. W., Kavoussi, L. R. and Catalona, W. J.: Role of nerve-sparing radical prostatectomy for clinical stage B2 prostate cancer. J. Urol., 144: 1420, 1990.
4. Anscher, M. S. and Prosnitz, L. R.: Postoperative radiotherapy for patients with carcinoma of the prostate undergoing radical prostatectomy with positive surgical margins, seminal vesicle involvement and/or penetration through the capsule. J. Urol., 138: 1407, 1987.
5. Bosch, R. J. L. H., Kurth, K. H. and Schroeder, F. H.: Surgical treatment of locally advanced (T3) prostatic carcinoma: early results. J. Urol., 138: 816, 1987.
6. Gibbons, R. P., Cole, B. S., Richardson, R. G., Correa, R. J., Jr., Brannen, G. E., Mason, J. T., Taylor, W. J. and Hafermann, M. D.: Adjuvant radiotherapy following radical prostatectomy: results and complications. J. Urol., 135: 65, 1986.
7. Schellhammer, P. F.: Radical prostatectomy. Patterns of local failure and survival in 67 patients. Urology, 31: 191, 1988.
8. Lange, P. H., Ercole, C. J. and Vessella, R. L.: Serum prostatic specific antigen (PSA) in the management of patients after radical prostatectomy (RP). J. Urol., part 2, 139: 314A, abstract 607, 1988.
9. Paulson, D. F., Moul, J. W. and Walther, P. J.: Radical prostatectomy for clinical stage T1-2 NOMO prostatic adenocarcinoma: long-term results. J. Urol., 144: 1180, 1990.
10. Harris, D. T. and Mastrangelo, M. J.: Theory and application of early systemic therapy. Sem. Oncol., 18: 493, 1991.
11. Olsson, C. A.: Editorial comment. J. Urol., 135: 1205, 1986.
12. Scott, W. W. and Boyd, H. L.: Combined hormone control therapy and radical prostatectomy in the treatment of selected cases of advanced carcinoma of the prostate: a retrospective study based on 25 years of experience. J. Urol., 101: 86, 1969.
13. Porter, A. T. and Venner, P. M.: The role of cytoreduction prior to definitive radiotherapy in locally advanced prostate cancer - the Canadian perspective. Prog. Clin Biol. Res., 359: 231, 1990.
14. Tunn, U. W. and Goldschmidt, A. J. W.: Effects of temporary antiandrogenic treatment prior to radical prostatectomy. In: Recent Advances in Urological Cancers. Diagnosis and Treatment. Edited by G. Khoury, C. Chatelain and L. Denis. Paris: Scientific Communications International, Ltd., 1990.
15. Ayala, A. G., Ro, J. Y., Babaian, R., Troncoso, T. and Grignon, D. J.: The prostatic capsule: does it exist? Its importance in the staging and treatment of prostatic carcinoma. Amer. J. Surg. Path., 13: 21, 1989.
16. Soloway, M. S., Sharifi, R., Wajsman, Z., McLeod, D., Wood, D. P., Jr. and Puras-Baez, A. for the Lupron Depot Neoadjuvant Prostate Cancer Study Group: Randomized prospective study comparing radical prostatectomy alone versus radical prostatectomy preceded by androgen blockade in clinical stage B2 (T2bN×M0) prostate cancer. J. Urol., 154: 424, 1995.
17. Van Poppel, H., De Ridder, D., Elgamal, A. A., Van de Voorde, W., Werbrouck, P., Ackaert, K., Oyen, R., Pittomvils, G., Baert, L. and members of the Belgian Uro-Oncological Study Group: Neoadjuvant hormonal therapy before radical prostatectomy decreases the number of positive surgical margins in stage T2 prostate cancer: interim results of a prospective randomized trial. J. Urol., 154: 429, 1995.
18. Schulman, C. C.: Neoadjuvant androgen blockade prior to prostatectomy: a retrospective study and critical review. Prostate, suppl., 5: 9, 1994.
19. Fair, W. R., Aprikian, A. G., Cohen, D., Sogani, P. and Reuter, V.: Use of neoadjuvant androgen deprivation therapy in clinically localized prostate cancer. Clin. Invest. Med., 16: 516, 1993.
20. Labrie, F., Dupont, A., Cusan, L. and Gomez, J. L.: Downstaging of localized prostate cancer by neoadjuvant therapy with flutamide and lupron: the first controlled and randomized trial. Clin. Invest. Med., 16: 499, 1993.
21. Ackerman, D. A., Barry, J. M., Wicklund, R. A., Olson, N. and Lowe, B. A.: Analysis of risk factors associated with prostate cancer extension to the surgical margin and pelvic node metastasis at radical prostatectomy. J. Urol., 150: 1845, 1993.
22. Van Poppel, H., Ameye, F., Oyen, R., Van de Voorde, W. and Baert, L.: Neo-adjuvant hormonotherapy does not facilitate radical prostatectomy. Acta Urol. Belg., 60: 73, 1992.
23. Macfarlane, M. T., Abi-Aad, A., Stein, A., Danella, J., Belldegrun, A. and deKernion, J. B.: Neoadjuvant hormonal deprivation in patients with locally advanced prostate cancer. J. Urol., 150: 132, 1993.
24. Igel, T. C., Barrett, D. M., Segura, J. W., Benson, R. C., Jr. and Rife, C. C.: Perioperative and postoperative complications from bilateral pelvic lymphadenectomy and radical retropubic prostatectomy. J. Urol., 137: 1189, 1987.