Mechanism of FK506-induced renal hypoperfusion and its reversion in rats

Acta Pharmacologica Sinica

Volumn 22, Issue 11, 2001, Pages 1034-1038

  Chen, Jia Cun ^a   Ma, Ping ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Calcium channel blockers; Endothelins; Kidney; Nephrotoxicity; Perfusion; Rats; Tacrolimus

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; ENDOTHELIN; IMMUNOSUPPRESSIVE AGENT; TSUKUBAENOLIDE;

ANIMAL; ARTICLE; DRUG EFFECT; DRUG INTERACTION; GLOMERULUS FILTRATION RATE; IATROGENIC DISEASE; KIDNEY; KIDNEY DISEASE; MALE; METABOLISM; METHODOLOGY; MICTURITION; PERFUSION; RAT; RAT STRAIN; VASCULARIZATION;

ANIMAL; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DRUG INTERACTIONS; ENDOTHELINS; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY DISEASES; MALE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS; URINATION;

EID: 0039298007     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Mor E, Patel T, Glabman S, Sheiner P, Emre S, Guy S, et al. Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. Transpl Int 1994; 7 (Suppl 1): S77-S80.
2. Platz KP, Mueller AR, Blumhardt G, Bachmann S, Bechstein WO, Kahl A, et al. Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients. Transpl Int 1994; 7 (Suppl 1): S52-S57.
3. Porayko MK, Textor SC, Krom RA, Hay JE, Gores GJ, Wahstrom HE, et al. Nephrotoxicity of FK-506 and cyclosporin when used as primary immunosuppression in liver transplantation. Transplant Proc 1993; 25: 665-8.
4. Randhawa PS, Shapiro R, Jordan MI, Starzl TE, Demetris AJ. The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Am J Surg Pathol 1993; 17: 60-8.
5. Bunchman TE, Brockahire CA. Cyclosporin-induced synthesis of endothelin by cultured human endothelial cells. J Clin Invest 1991; 88: 310-4.
6. Perico N, Ruggenenti P, Gaspari F, Mosconi L, Benigni A, Amuchastegui CS. Daily renal hypoperfusion induced by cyclosporin in patients with renal transplantation. Transplantation 1992; 53: 56-69.
7. Kon V, Sugiura M, Inagami T, Harvie BR, Ichikawa I, Hoover RL, et al. Role of endothelin in cyclosporin-induced glomerular dysfunction. Kidney Int 1990; 37: 1487-91.
8. Perico N, Dadan J, Remuzzi G. Endothelin mediates the renal vasoconstriction induced by cyclosporin in the rat. J Am Soc Nephrol 1990; 1: 76-83.
9. Kivilighn SD, Gabel RA, Siegl PK. Effects of BQ123 on renal function and acute cyclosporin-induced renal dysfunction. Kidney Int 1994; 45: 131-6.
10. Schoeffter P, Randriantsos A, Jost B, Bruttel K. Comparative effects of the two endothelin receptor antagonists, BQ123 and FR139317, on endothelin-induced contraction in guinea pig. Eur J Pharmacol 1993; 241: 165-9.
11. Nishitsutsuji-Uwo JM, Ross BD, Krebs HA. Metabolic activities of the isolated perfused rat kidney. J Biochem 1967; 103: 852-62.
12. Lo Russo A, Passaquin AC, Andre P, Skutella M, Ruegg UT. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity. Br J Pharmacol 1996; 118: 885-92.
13. Andoh TF, Burdmann EA, Lindsley J, Houghton DC, Bennett WM. Enhancement of FK 506 nephrotoxicity by sodium depletion in an experimental rat model. Transplantation 1994; 57: 483-9.
14. Awazu M, Sugiura M, Inagami T, Ichikawa I, Kon V. Cyclosporin promotes glomerular endothelin binding in vivo. J Am Soc Nephrol 1991; 1: 1253-9.
15. Iwasaki S, Homma T, Kon V. Site specific regulation in the kidney of endothelin and its receptor subtypes of cyclosporin. Kidney Int 1994: 45:592-7.
16. Deprez-Roy I, Coge F, Bertry L, Galizzi JP, Feletou M, Vanhoutte PM, et al. Endothelin-1 pathway in human alveolar epithelial cell line A549 and human umbilical vein endothelial cell. Acta Pharmacol Sin 2000; 21: 499-506.
17. Finn WF. FK506 nephrotoxicity. Ren Fail 1999; 21: 319-29.
18. Zhu HB, Geng MY, Guan HS. Antihypertensive effects of D-polymannuronic sulfate and its related mechanism in renovascular hypertensive rat. Acta Pharmacol Sin 2000; 21: 727-32.
19. Ruggenenti P, Perico N, Mosconi L, Gaspari F, Mosconi L, Benigni A, et al. Calcium channel blockers protect transplant patients from cyclosporin-induced daily renal hypoperfusion. Kidney Int 1993; 43: 706-11.
20. Huntress JD, Papadakos PJ. The role of calcium-channel antagonists in solid organ transplantation. New Horiz 1996; 4: 129-33.