Spin Trapping with 5-Methyl-5-phenylpyrroline N-Oxide. A Replacement for 5,5-Dimethylpyrroline N-Oxide

Journal of Organic Chemistry

Volumn 62, Issue 4, 1997, Pages 1176-1178

  Sankuratri, Nagaraju ^a   Janzen, Edward G ^a,b   West, Melinda S ^a   Poyer, J Lee ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0039080573     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961476x     Document Type: Article

References (23)

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3. Kotake, Y.; Reinke, L. A.; Tanigawa, T.; Koshida, H. Free Radical Biol. Med. 1994, 17, 215.
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5. Powell, S. R. Free Radical Res. 1994, 21, 355.
6. Tomasi, A.; Iannone, A. In EMR of Paramagnetic Molecules - Biol. Magn. Reson. Plenum Press: New York, NY, 1993; Vol. 13, Chapter 9, p 353.
7. Janzen, E. G.; Haire, D. L. In Advances in Free Radical Chemistry; Tanner, D. D., Ed.; JAI Press, Inc.: Greenwich, CT, 1990, Chapter 6, p 253.
8. Janzen, E. G. In Bioradicals Detected by ESR Spectroscopy; Ohya-Nishiguchi, Packer, L., Eds.; Birkhaüser Verlag: Switzerland, 1995; p 113.
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11. (a) Janzen, E. G. Free Radical Biol. 1980, 4, 115.
12. (b) McCay, P. B.; Noguchi, T.; Fong, K.-L.; Lai, E. K.; Poyer, J. L. Free Radical Biol. 1980, 4, 153.
13. (c) Janzen, E. G. In Oxygen Radicals in Biological Systems, Methods in Enzymology; Packer, L., Ed.; Academic Press, Inc.: New York, NY, 1984; Vol. 105, p 188.
14. (d) Mason, R. P. In Spin Labeling in Pharmacology; Holtzman, J. L., Ed.; Academic Press: New York, 1984; p 87.
15. (e) Rosen, G. M. Adv. Free Radical Biol. Med. 1985, 1, 345.
16. (f) Mason, R. P.; Maples, K. R.; Knecht, K. T. Electron Spin Resonance; Symons, M. C. R., Ed.; Royal Society of Chemistry: London, 1989, Vol. 11B, p 1.
17. (g) Dodd, N. S. F. Electron Spin Resonance; Symons, M. C. R. Ed.; Royal Society of Chemistry: London, 1990, Vol. 12A, p 136.
18. (a) Lurie, D. L.; McLay, J.; Nicholson, I.; Mallard, J. R. J. Magn. Reson. 1991, 95, 191.
19. (b) Halpern, H. J.; Pou, S.; Peric, M.; Yu, C.; Barth, E.; Rosen, G. M. J. Chem. Soc. 1993, 115, 218.
20. (c) Halpern, H. J.; Yu, C.; Barth, E.; Peric, M.; Rosen, G. M. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 796. Recently phosphorylated spin traps have been published with more persistent spin adducts but additional hyperfine splittings are produced in this case: Zeghdaoui, A.; Tuccio, B.; Finet, J.-P.; Cerri, V.; Tordo, P. J. Chem. Soc., Perkin Trans. 2. 1995, 2087 and references therein.
21. (c) Halpern, H. J.; Yu, C.; Barth, E.; Peric, M.; Rosen, G. M. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 796. Recently phosphorylated spin traps have been published with more persistent spin adducts but additional hyperfine splittings are produced in this case: Zeghdaoui, A.; Tuccio, B.; Finet, J.-P.; Cerri, V.; Tordo, P. J. Chem. Soc., Perkin Trans. 2. 1995, 2087 and references therein.
22. Janzen, E. G.; Sankuratri, N.; Kotake, Y. J. Magn. Reson. B. 1996, 111, 254-261.
23. 4 in the rat (work with Dr. J. L. Poyer and Ms. M. S. West in these laboratories). When DMPO is used, usually no spin adduct is obtained. Very occasionally a weak EPR signal is recorded but this result is not reproducable.