Effect of corticosteroids on the balance of Th cytokines in patients with systemic lupus erythematosus

Bulletin of Hunan Medical University

Volumn 27, Issue 6, 2002, Pages 533-535

  Xie, Hong Fu ^a   Li, Jie ^a   Shi, Wei ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Corticosteroids; Lupus erythematosus, systemic; Th1 Th2 cytokine; Treatment

Indexed keywords

CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; ANTIINFLAMMATORY AGENT; INTERLEUKIN 2; PREDNISONE;

ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MAJOR CLINICAL STUDY; SCORING SYSTEM; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; TH2 CELL; ADOLESCENT; ADULT; BLOOD; CHILD; FEMALE; IMMUNOLOGY; MALE;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; CHILD; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PREDNISONE;

EID: 0038819536     PISSN: 10005625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI A Disease Activity Index for Lupus Patients[J]. Arthritis Rhumatism, 1992,35:630-639.
2. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted protiens[J]. J Immunol, 1986, 136: 2348-2357.
3. Wong CK, Ho CY, Li EK, et al. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and TH2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosous[J]. Lupus, 2001,9:589-593.
4. Viallard JF, Pellegrin JL, Ranchin V, et al. Th1 (IL-2, interferon-gamma(IFN-γ) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cell (PMBC) from patients with systemic lupus erythematosous (SLE) [J]. Clin Exp Immunol, 1999;115;189-195.
5. Ashwell JD, Lu FW, Vacchio MS. Glucocorticoids in T cell development and function [J]. Annu Rev Immunol, 2000,18:309-345.
6. Norbiato G, Bevilacqua M, Vago T. Glucocorticoids and Th-1, Th-2 cytokines in rheumatoid arthritis, osteoarthritis, asthma, atopic dermatitis and AIDS[J]. Clin Exp Rheumatoid, 1997, 15:315-323.
7. Mysliwiec J, Kretowski A, Toplskal J, et al. Serum Th1 and Th2 profile cytokine level changes in patients with Graves Ophthalmopathy treatment with corticosteroids[J]. Horm Metab Res, 2001,33:739-743.
8. Agarwal SK, Marshall GDJR. Dexamethasone promotes type 2 cytokine production primarily through inhibition of type 1 cytokines[J]. J Interferon Cytokine Res, 2001,21:147-155.