Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys

Biopharmaceutics and Drug Disposition

Volumn 24, Issue 4, 2003, Pages 141-151

  Kondo, Hiromu ^a   Watanabe, Takashi ^a   Yokohama, Shigeharu ^a   Watanabe, Jun ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Cynomolgus monkeys; Fed; Gastric emptying rate; Liquids; Oro caecal; Transit time

Indexed keywords

PARACETAMOL; SALAZOSULFAPYRIDINE; SULFADIAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; FLUID TRANSPORT; FOOD; FOOD INTAKE; GASTROINTESTINAL TRANSIT; HUMAN VERSUS ANIMAL COMPARISON; INTESTINE TRANSIT TIME; MONKEY; NONHUMAN; STOMACH ACID SECRETION; STOMACH EMPTYING; STOMACH PH;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; FOOD; GASTRIC ACIDITY DETERMINATION; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; HUMANS; MACACA FASCICULARIS; MALE; MODELS, ANIMAL; SULFAPYRIDINE; SULFASALAZINE; TIME FACTORS;

EID: 0038813878     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.349     Document Type: Article

References (31)

1. Welling PG. Effects of food on drug absorption. Pharmac Ther 1989; 43: 425-441.
2. Singh BN. Effects of food on clinical pharmacokinetics. Clin Pharmacokinet 1999; 37: 213-255.
3. Johansson C. Studies in gastrointestinal interactions IV. Gastric emptying of a composite meal in man. The influence of glucose. Scand J Gastroenterol 1973; 8: 533-539.
4. Hunt JN, Stubbs DF. The volume and energy content of meals as determinants of gastric emptying. J Physiol 1975; 245: 209-225.
5. Read NW, Al Janabi MN, Bates TE, Barber DC. Effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humans. Gastroenterology 1983; 84: 1568-1572.
6. Moore JG, Christian PE, Brown JA, et al. Influence of meal weight and caloric content on gastric emptying of meals in man. Dig Dis Sci 1984; 29: 513-519.
7. Velchik MG, Reynolds JC, Alavi A. The effect of meal energy content on gastric emptying. J Nucl Med 1989; 30: 1106-1110.
8. Nakae Y, Onouchi H, Kagaya M, Kondo T. Effect of aging and gastric lipolysis on gastric emptying of lipid in liquid meal. J Gastroenterol 1999; 34: 445-449.
9. Yao M, Roberts SB. Dietary energy density and weight regulation. Nutr Rev 2001; 59: 247-258.
10. Lennernas H, Fager G. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Clin Pharmacokinet 1997; 32: 403-425.
11. Prokop EK, Cardie VJ, Marano AR, McCallum R. Scintigraphic determination of small intestine transit time of water in man. J Nud Med 1984; 25: P97.
12. Hardy JG, Davis SS, Wilson CG. Gastrointestinal transit of pharmaceutical preparations. J Nuc Med 1984; 25: P59.
13. Christensen FN, Davis SS, Hardt JG, Taylor MJ, Whalley DR, Wilson CG. The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulations. J Pharm Pharmacol 1985; 37: 91-95.
14. Davis SS, Hardy JG, Fara JW. Transit of pharmaceutical dosage forms through the small intestine. Gut 1986; 27: 886-892.
15. Sommers DK, Meyer EC, Van Wyk M, Moncrieff J, Snyman JR, Grimbeek RJ. The influence of codeine, propantheline and metoclopramide on small bowel transit and theophylline absorption from a sustained-release formulation. Br J Clin Pharmac 1992; 33: 305-308.
16. Kondo H, Takahashi Y, Watanabe T, Yokohama S, Watanabe J. Gastrointestinal transit of liquids in unfed cynomolgus monkeys. Biopharm Drug Dispos. 2003; 24: 131-140.
17. Clements JA, Heading RC, Nimmo WS, Prescott LF. Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther 1978; 24: 420-431.
18. Heading RC, Nimmo J, Prescott LF, Tothill P. The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmac 1973; 47: 415-421.
19. Maddern G, Miners J, Collins PJ, Jamieson GG. Liquid gastric emptying assessed by direct and indirect techniques: Radionuclide labelled liquid emptying compared with a simple paracetamol marker method. Aust N.Z. J Surg 1985; 55: 203-206.
20. Staniforth DH. Comparison of orocaecal transit time assessed by the lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods. Gut 1989; 30: 978-982.
21. Kennedy M, Chinwah P. Wade DN. A pharmacological method of measuring mouth caecal transit time in man. Br J Clin Pharmac 1979; 8: 372-373.
22. Kondo H, Shinoda T, Nakashima. H, Watanabe T, Yokohama S. Characteristics of the gastric pH profiles of unfed and fed cynomolgus monkeys as pharmaceutical product development subjects. Biopharm Drug Dispos 2003; 24: 45-49.
23. Hardy JG, Wilson CG, Wood E. Drug delivery to the proximal colon. J Pharm Pharmacol 1985; 37: 874-877.
24. Willems M, Quartero AO, Numans ME. How useful is paracetamol absorption as a marker of gastric emptying? Dig Dis Sci 2001; 46: 2256-2262.
25. Cohen J, Aharon A, Singer P. The paracetamol absorption test: A useful addition to the enteral nutrition algorithm? Clin Nutr 2000; 19: 233-236.
26. Medhus AW, Lofthus CM, Bredesen J, Husebye E. Gastric emptying: The validity of the paracetamol absorption test adjusted for individual pharmacokinetics. Neurogastroenterol Mot 2001; 13: 179-185.
27. Chiou WL. Estimation of hepatic first-pass effect of acetaminophen in humans after oral administration. J Pharm Sci 1975; 64: 1734-1735.
28. Iga K, Ogawa Y, Yashiki T, Shimamoto T. Estimation of drug absorption rates using a deconvolution method with nonequal sampling times. J Pharmacokin Biopharm 1986; 14: 213-225.
29. Russell TL, Berardi RR, Barnett JL, et al. Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women. Pharin Res 1993; 10: 187-196,
30. McLauchlan G, Fullarton GM, Crean GP, McColl KEL. Comparison of gastric body and antral pH: A 24 h ambulatory study in healthy volunteers. Gut 1989; 30: 573-578.
31. Zimmermann T, Laufen H, Yeates RA, Lammerich A, Wildfeuer A. Techniques for measuring gastrointestinal pH and transit, and their application in drug development. In t J Pharm Med 1999; 13: 147-154.