New PNA tool makes great antisense

Drug Discovery Today

Volumn 8, Issue 12, 2003, Pages 520-521

  Foubister, Vida ^a  

^a NONE

Author keywords

Antisense; Biochemistry; Cell biology; DNA; Drug Discovery; Molecular Medicine; Pharmaceutical Science; PNA; Quadruplex

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; CYTOSINE; DNA; GUANINE; NUCLEASE; PEPTIDE NUCLEIC ACID; PROTEINASE; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; BASE PAIRING; BINDING AFFINITY; BINDING SITE; CHROMOSOME; DNA SEQUENCE; DNA STRAND; DNA STRUCTURE; DRUG MECHANISM; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE REPRESSION; HYDROGEN BOND; NEUROPATHOLOGY; ONCOGENE; ONCOGENE C MYC; PROTEIN DEGRADATION; PROTOZOON; RNA BINDING; ROOM TEMPERATURE; SHORT SURVEY; TELOMERE;

DNA; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS;

EID: 0038799793     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02736-3     Document Type: Short Survey

References (4)

1. 2 hybrid quadruplex. J. Am. Chem. Soc. 125:2003;4111-4118.
2. Nielsen P.E., et al. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science. 254:1991;1497-1500.
3. Smith F.W., Feigon J. Quadruplex structure of telomeric DNA oligonucleotides. Nature. 356:1992;164-168.
4. Siddiqui-Jain A., et al. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. U. S. A. 99:2002;11593-11598.