Promoting effect of a mixture of 8 herbal extracts (SPELA 707) on hair growth

Korean Journal of Physiology and Pharmacology

Volumn 7, Issue 2, 2003, Pages 91-96

  Choi, Eun Young ^d   Park, Soo Nam ^a   Park, Sung Uk ^b   Choi, Seongwon ^d   In Ro, Byung ^c   Chung, Myung Hee ^d  

^a Seoul National University of Science and Technology   (South Korea)

^b SPELA Co Ltd   (South Korea)

^c Chung Ang University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

Androgenetic alopecia; C3H mouse; Hair growth; Phototrichogram; Steroid 5 reductase

Indexed keywords

ANGELICA EXTRACT; CARTHAMI EXTRACT; CNIDIUM RHIZOME; FINASTERIDE; GINSENG EXTRACT; GLYCYRRHIZA EXTRACT; HERBACEOUS AGENT; MINOXIDIL; PERSICAE EXTRACT; PLANT EXTRACT; SALVIA EXTRACT; SPELA 707; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG; ZANTHOXYLI EXTRACT;

ADOLESCENT; ADULT; ANGELICA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTHAMI; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GINSENG; GLYCYRRHIZA; HAIR GROWTH; HAIR LOSS; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; MALE TYPE ALOPECIA; MEDICINAL PLANT; MOUSE; NONHUMAN; PERSICAE; SALVIA; SCHOOL CHILD; TRADITIONAL MEDICINE; WOUND HEALING; ZANTHOXYLI;

EID: 0038789131     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Amagaya S, Sugishita E, Ogihara Y, Ogawa S, Okada K, Aizawa T. Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-inflammatory activities. J Pharmacobiodyn 7(12): 923-928, 1984
2. Bingham KD, Shaw DA. The metabolism of testosterone by human male scalp skin. J Endocri 57: 111-121, 1973
3. Dallob AL, Sadick NS, Unger W, Lipert S, Geissler LA, Gregoire SL, Nguyen HH, Moore EC, Tanaka WK. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. J Clin Endocrinol Metab 79(3): 703-706, 1994
4. Douglas C. Photographic documentation of hair growth in androgenetic alopecia. Dermatol Clin 14(4): 713-721, 1996
5. Gormley GJ. Finasteride: a clinical review. Biomed Pharmacother 49(7-8): 319-324, 1995
6. Hattori M, Ogawa H. Biochemical analysis of hair growth from the aspects of aging and enzyme activities. J Dermatol 10(1): 45-54, 1983
7. Hoffmann R. Enzymology of the hair follicle. Eur J Dermatol 11 (4): 296-300, 2001
8. Hu H, Hang B, Wang P. Anti-inflammatory effect of radix Angelicae sinensis. Zhongguo Zhong Yao Za Zhi 16(11): 684-686, 1991
9. Jiang KY, Qian Zn. Effects of Panax notoginseng saponins on posthypoxic cell damage of neurons in vitro. Zhongguo Yao Li Xue Bao 16(5): 399-402, 1995
10. Kim HC. Herbal Pharmacology. Jip Moon Dang, Seoul, 2001
11. Kim HK, Kim HM, Song BK, Lee YJ, Chung HT. Herbal Pharmacology. Korea Medical Book, Seoul, p 285-289, 2000
12. Kuttenn F, Mowszowicz I, Schaison G, Mauvais-Jarvis P. Androgen production and skin metabolism in hirsutism. J Endocr 75: 83-91, 1977
13. Liang T, Cascieri MA, Cheung AH, Reynolds GF, Rasmusson GH. Species differences in prostatic steroid 5 alpha-reductases of rat, dog, and human. Endocrinology 117(2): 571-579, 1985
14. Maurer M, Handjiski B, Paus R. Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. Am J Pathol 150: 1433-1441, 1997
15. McClellan KJ, Markham A. Finasteride: a review of its use male pattern hair loss. Drugs 57(1): 111-126, 1999
16. Nagai M, Noguchi M, Iizuka T, Otani K, Kamata K. Vasodilator effects of des (alpha-carboxy-3, 4-dihydroxyphenethyl) lithospermic acid (8-epiblechnic acid), a derivative of lithospermic acids in salviae miltiorrhizae radix. Biol Pharm Bull 19(2): 228-232, 1996
17. Price VH. Treatment of hair loss. N Engl J Med 341: 964-973, 1999
18. Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK. The hair growth promoting effect of Sophora flavescens extract and its molecular regulation. J Dermatol Sci 30: 43-49, 2002
19. Saitoh M, Uzuka M, Sakamoto M. Human hair cycle. J Invest Dermatol 54(1): 65-81, 1970
20. Shi W, Fu S, Du N. Effect of effective fraction of Radix Salviae Miltiorrhizae on procollagen gene expressionin fracture healing. Zhongguo Zhong Xi Yi Jie He Za Zhi 20(4): 269-271, 2000
21. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985
22. Takahashi T, Kamiya T, Yokoo Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venereol 78: 428-432, 1998
23. Takeda A, Katoh N, Yonezawa M. Restoration of radiation injury by ginseng. III. Radioprotective effect of thermostable fraction of ginseng extract on mice, rats and guinea pigs. J Radiat Res (Tokyo) 23(2): 150-167, 1982
24. Tanigaki-Obana N, Ito M. Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the marine hair apparatus. Arch Dermatol Res 284(5): 290-296, 1992
25. Uno H, Cappas A, Schlagel C. Cyclic dynamics of hair follicles and the effect of minoxidil on the bald scalps of stumptailed macaques. Am J Dermatopathol 7(3): 283-297, 1985
26. Whiting DA. Advances in the treatment of male androgenetic alopecia: a brief review of finasteride studies. Eur J Dermatol 11(4): 332-334, 2001
27. Wilson JD. The pathogenesis of benign prostatic hyperplasia. Am J Med 68: 745-756, 1980
28. Yonezawa M, Katoh N, Takeda A. Restoration of radiation injury by ginseng. IV. Stimulation of recoveries in CFUs and megakaryocyte counts related to the prevention of occult blood appearance in X-irradiated mice. J Radiat Res (Tokyo) 26(4): 436-442, 1985