Circulating thrombomodulin levels are related to latent progression of atherosclerosis in hypertensive patients

Hypertension Research

Volumn 26, Issue 6, 2003, Pages 479-483

  Dohi, Yasuaki ^a   Ohashi, Masuo ^a   Sugiyama, Masaya ^a   Takase, Hiroyuki ^b   Sato, Koichi ^c   Ueda, Ryuzo ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b Enshu General Hospital   (Japan)

^c Johoku Hospital   (Japan)

Author keywords

Atherosclerosis; Essential hypertension; Fundus oculi; Pulse wave velocity; Thrombomodulin

Indexed keywords

BIOLOGICAL MARKER; CREATININE; LIPID; THROMBOMODULIN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; BLOOD VESSEL INJURY; CALCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME IMMUNOASSAY; ESSENTIAL HYPERTENSION; EYE FUNDUS; FEMALE; HUMAN; HYPOTHESIS; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PULSE WAVE; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION;

AGED; ARTERIOSCLEROSIS; CREATININE; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; ELECTROCARDIOGRAPHY; FEMALE; FUNDUS OCULI; HUMANS; HYPERTENSION; LIPIDS; MALE; MIDDLE AGED; SCLEROSIS; THROMBOMODULIN;

EID: 0038784677     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.26.479     Document Type: Article

References (31)

1. Sadler JE: Thrombomodulin structure and function. Thromb Haemost 1997; 78: 392-395.
2. Maruyama I, Bell CE, Majerus PW: Thrombomodulin is found on endothelium of arteries, veins, capillaries, lymphatic, and on syncytiotrophoblast of human placenta. J Cell Biol 1985; 101: 363-371.
3. Ishii H, Majerus PW: Thrombomodulin is present in human plasma and urine. J Clin Invest 1985; 76: 2178-2181.
4. Califano F, Giovanniello T, Pantone P, et al: Clinical importance of thrombomodulin serum levels. Eur Rev Med Pharmacol Sci 2000; 4: 59-66.
5. Borawski J, Mysliwiec M: Soluble thrombomodulin: a marker of endothelial injury, an antithrombotic agent, or both? Med Sci Monit 2001; 7: 785-786.
6. Ishii H, Uchiyama H, Kazama M: Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells, Thromb Haemost 1991; 65: 618-623.
7. Seigneur M, Dufourcq P, Conri C, et al: Plasma thrombomodulin: new approach of endothelial damage. Int Angiol 1993; 12: 355-359.
8. Seigneur M, Dufourcq P, Conri C, et al: Levels of plasma thrombomodulin are increased in atheromatous arterial disease. Thromb Res 1993; 71: 423-431.
9. Blann AD, Seigneur M, Steiner M, Boisseau MR, McCollum CN: Circulating endothelial cell markers in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease. Eur J Clin Invest 1997; 27: 916-921.
10. Blann AD, Amiral J, McCollum CN: Prognostic value of increased soluble thrombomodulin and increased soluble E-selectin in ischemic heart disease. Eur J Haematol 1997; 59: 115-120.
11. Peter K, Nawroth P, Conradt C, et al: Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intracellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin. Arterioscler Thromb Vasc Biol 1997; 17: 505-512.
12. Salomaa V, Matei C, Aleksic N, et al: Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis 2001; 157: 309-314.
13. Dohi Y, Kojima M, Sato K: Benidipine improves endothelial function in renal resistance arteries of hypertensive rats. Hypertension 1996; 28: 58-63.
14. Spieker LE, Noll G, Ruschitzka FT, Maier W, Luscher TF: Working under pressure: the vascular endothelium in arterial hypertension. J Hum Hypertens 2000; 14: 617-630.
15. Miyagawa K, Dohi Y, Kojima M, Sato K: Magnesium removal impairs the regulatory role of rat endothelium. Hypertens Res 2000; 23: 669-675.
16. Ross R: The pathogenesis of atherosclerosis: a perspective for 1990s. Nature 1993; 362: 801-809.
17. Erdem Y, Usalan C, Hanznedaroglu ÍC, et al: Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension. Am J Hypertens 1999; 11: 1071-1076.
18. Remková A, Kovácová E, Príkazská M, Kratochvíl'ová H: Thrombomodulin as a marker of endothelium damage in some clinical conditions. Eur J Int Med 2000; 11: 79-84.
19. Makris TK, Stavroulakis GA, Krespi PG, et al: Fibrinolytic/hemostatic variables in arterial hypertension: response to treatment with irbesartan or atenolol. Am J Hypertens 2000; 13: 783-788.
20. Perloff D, Grim C, Flack J, et al: Human blood pressure determination by sphygmomanometry. Circulation 1993; 88: 2460-2470.
21. Aso Y, Tayama K, Takanashi K, Inukai T, Takemura Y: Changes in skin blood flow in type 2 diabetes induced by prostacyclin: association with ankle branchial index and plasma thrombomodulin levels. Metabolism 2001; 50: 568-572.
22. Kubo T, Miyata M, Minagoe S, Setoyama S, Maruyama I, Tei C: A simple oscillometric technique for determining new indices of arterial distensibility. Hypertens Res 2002; 25: 351-358.
23. Yamashina A, Tomiyama H, Takeda K, et al: Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359-364.
24. John S, Drobnik W, Lackrer K, Schmieder RE: Soluble thrombomodulin and endothelial dysfunction in early atherosclerosis. Lancet 1999; 354: 1647.
25. Cohn JN: Vascular wall function as a risk marker for cardiovascular disease. J Hypertens 1999; 17 (Suppl 5): S41-S44.
26. Lehmann ED: Clinical value of aortic pulse-wave velocity measurement. Lancet 1999; 354: 528-529.
27. Laurent S, Boutouyrie P, Asmar R, et al: Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37: 1236-1241.
28. van Popele NM, Grobbee DE, Bots ML, et al: Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454-460.
29. Esmon CT: Defects in natural anticoagulant pathways as potential risk factors for myocardial infarction. Circulation 1997; 96: 9-11.
30. Ireland H, Kunz G, Kyriakoulis K, Stubbs PJ, Lane DA: Thrombomodulin gene mutations associated with myocardial infarction. Circulation 1997; 96: 15-18.
31. Salomma V, Matei C, Aleksic N, et al: Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the atherosclerosis risk in communities (ARIC) study: a case-cohort study. Lancet 1999; 353: 1729-1734.