Precursors of Borna disease virus-specific T cells in secondary lymphatic tissue of experimentally infected rats

Journal of NeuroVirology

Volumn 9, Issue 3, 2003, Pages 325-335

  Batra, Arvind ^a   Planz, Oliver ^a   Bilzer, Thomas ^b   Stitz, Lothar ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Borna disease virus; Cytotoxicity; Encephalitis; Immunopathology; T cells

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD8 ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BORNA DISEASE; BORNA DISEASE VIRUS; BRAIN CELL; BRAIN INFECTION; CELL CULTURE; CELL ISOLATION; CELL LABELING; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM DISEASE; CERVICAL LYMPH NODE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EXPERIMENTAL INFECTION; EXPERIMENTAL MODEL; IMMUNE DEFICIENCY; IMMUNOPATHOLOGY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE HOMING; LYMPHOCYTE TRANSFER; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; MESENTERY LYMPH NODE; NERVE CELL LESION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; RAT; RECIPIENT; SPLEEN; SYMPTOM; T LYMPHOCYTE;

ANIMALIA; BORNA DISEASE VIRUS;

EID: 0038784611     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280390201038     Document Type: Article

References (27)

1. Bilzer T, Stitz L (1994). Immune-mediated brain atrophy: CD8+ T cells contribute to tissue destruction during Borna disease. J Immunol 153: 818-823.
2. Deschl U, Stitz L, Herzog S, Frese K, Rott R (1990). Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease. Acta Neuropathol (Berl) 81: 41-50.
3. Hausmann J, Hallensleben W, de la Torre JC, Pagenstecher A, Zimmermann C, Pircher H, Staeheli P (1999). T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. Proc Natl Acad Sci USA 96: 9769-9774.
4. Hickey WF, Hsu BL, Kimura H (1991). T-lymphocyte entry into the central nervous system. J Neurosci Res 28: 254-260.
5. Hirano N, Kao M, Ludwig H (1983). Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J Gen Virol 64: 1521-1530.
6. + cytotoxic T lymphocytes by dendritic cells. J Exp Med 166: 182-194.
7. Irani DN, Griffin DE (1991). Isolation of brain parenchymal lymphocytes for flow cytometric analysis. J Immunol Methods 139: 223-231.
8. Lewis AJ, Whitton JL, Hatalski CG, Weissenbock H, Lipkin WI (1999). Effect of immune priming on Borna disease. J Virol 73: 2541-2546.
9. Matsumoto Y, Ohmori K, Fujiwara M (1992). Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cell under in vivo-mimicking conditions. Immunology 76: 209-216.
10. Mims CA (1960). Intracerebral injections and the growth of viruses in the mouse brain. Br J Exp Pathol 41: 52-59.
11. Narayan O, Herzog S, Frese K, Scheefers K, Rott R (1983a). Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148: 305-315.
12. Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983b). Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science 220: 1401-1403.
13. Nöske K, Bilzer T, Planz O, Stitz L (1998). Virus-specific CD4+ T cells eliminate Borna disease virus from the brain via induction of cytotoxic CD8+ T cells. J Virol 72: 4387-4395.
14. Oehen S, Brduscha-Riem K, Oxenius A, Odermatt B (1997). A simple method for evaluating the rejection of grafted spleen cells by flow cytometry and tracing adoptively transferred cells by light microscopy. J Immunol Methods 207: 33-42.
15. Planz O, Bilzer T, Sobbe M, Stitz L (1993). Lysis of MHC class I-bearing cells in Borna disease virus-induced degenerative encephalopathy. J Exp Med 178: 163-174.
16. Planz O, Bilzer T, Stitz L (1995). Immunopathogenic role of T-cell subsets in Borna disease virus-induced progressive encephalitis. J Virol 69: 896-903.
17. Planz O, Dumrese T, Hulpüsch S, Schirle M, Stevanovic S, Stitz L (2001). A naturally processed rat major histocompatibility complex class I-associated viral peptide as target structure of borna disease virus-specific CD8+ T cells. J Biol Chem 276: 13689-13694.
18. Planz O, Stitz L (1999). Borna disease virus nucleoprotein (p40) is a major target for CD8(+)-T-cell-mediated immune response. J Virol 73: 1715-1718.
19. Richt JA, Schmeel A, Frese K, Carbone KM, Narayan O, Rott R (1994). Borna disease virus-specific T cells protect against or cause immunopathological Borna disease. J Exp Med 179: 1467-1473.
20. + T-cell mediated immune reaction. J Gen Virol 71: 2565-2573.
21. Richt JA, Stitz L, Wekerle H, Rott R (1989). Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain. J Exp Med 170: 1045-1050.
22. Rubin SA, Yednock TA, Carbone KM (1998). In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection. J Neuroimmunol 84: 158-163.
23. + T cell responses in the central nervous system. J Exp Med 173: 1235-1246.
24. Sobbe M, Bilzer T, Gommel S, Nöske K, Planz O, Stitz L (1997). Induction of degenerative brain lesions after adoptive transfer of brain lymphocytes from Borna disease virus-infected rats: presence of CD8+ T cells and perforin mRNA. J Virol 71: 2400-2407.
25. Stitz L, Planz O, Bilzer T, Frei K, Fontana A (1991). Transforming growth factor-β modulates T cell-mediated encephalitis caused by Borna disease virus. Pathogenic importance of CD8+ cells and suppression of antibody formation. J Immunol 147: 3581-3586.
26. Stitz L, Sobbe M, Bilzer T (1992). Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats. J Virol 66: 3316-3323.
27. Stitz L, Soeder D, Deschl U, Frese K, Rott R (1989). Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus infected rats by cyclosporine A. J Immunol 143: 4250-4256.