Investigations of anti-inflammatory and analgesic activities of prednisolone solid dispersion prepared with skimmed milk

Polish Journal of Pharmacology

Volumn 55, Issue 2, 2003, Pages 261-265

  Sahin, Nefise O ^a   Librowski, Tadeusz ^b  

^a MERSIN UNIVERSITY   (Turkey)

^b JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Analgesic activity; Anti inflammatory effect; Hind paw edema test; Prednisolone; Skimmed milk; Solid dispersion

Indexed keywords

PREDNISOLONE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG FORMULATION; DRUG SOLUBILITY; EDEMA; GASTRITIS; MALE; MILK; NONHUMAN; RAT; STOMACH MUCOSA;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL AVAILABILITY; CARRAGEENAN; DRUG CARRIERS; MALE; MILK; PAIN; PREDNISOLONE; RATS; RATS, WISTAR; SOLUBILITY;

EID: 0038784378     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Chiou W.L.: Pharmaceutical applications of solid dispersion systems: X-ray diffraction and aqueous solubility studies on griseofulvin-polyethylene glycol 6000 systems. J. Pharm. Sci., 1977, 66, 989-991.
2. Chiou W.L., Riegelman S.: Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci., 1971, 60, 1281-1302.
3. Craig D.Q.M.: The mechanism of drug release from solid dispersions in water-soluble polymers. Int. J. Pharm., 2002, 231, 131-144.
4. Eddy N.B., Leimbach D.: Synthetic analgesics II. Dithienylbutenyl- and dithienyl-butylamines J. Pharmacol. Exp. Ther., 1953, 107, 385-393.
5. Gotzsche P.C., Johansen H.K.: Meta-analysis of short-term low dose prednisolone vs placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis. BMJ, 1998, 811-818.
6. Jachowicz R., Nürnberg E., Pieszczek B., Kluczykowska B., Maciejewska A.: Solid dispersion of ketoprofen in pellets. Int. J. Pharm., 2000, 206, 13-21.
7. Nagarsenker M.S., Meshram R.N., Ramprakash G.: Solid dispersion of hydroxypropyl beta-cyclodextrin and ketorolac: enhancement of in-vitro dissolution rates, improvement in anti-inflammatory activity and reduction in ulcerogenicity in rats. J. Pharm. Pharmacol., 2000, 52, 949-956.
8. Paul-Clark M.J., Mancini L., Del Soldato P., Flower R.J., Perretti M.: Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. Proc. Nat. Acad. Sci. USA, 2002, 99, 1677-1682.
9. Randal L.O., Selitto J.J.: A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther., 1957, 111, 409-419.
10. Sahin N.O., Breitkreutz J., Librowski T.: Physicochemical characteristics of solid dispersions of prednisolone prepared with skimmed milk and modulation of gastric side effect of prednisolone. AAPS Pharm. Sci., in press.
11. Schacke H., Docke W.D., Asadullah K.: Mechanism involved in the side effects of glucocorticoids. Pharmacol. Ther., 2002, 96, 23-43.
12. Sokal R.R., Rohlf F.J.: Student t-Test in Biometry, 2 edn., NY, W.H. Freeman and Company, 1981, 145-147.
13. The Merck Index, Thirteenth edition. Ed. Susan Badavari, NJ, Merck & Co. Inc., 1379-1380, 2001.
14. Topaloglu Y.: Pharmaceutical, pharmacokinetical and pharmacological investigations on basic amino acid-indomethacin compounds. Thesis for associate professorship, Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, 1980.
15. Topaloglu Y.: The preparation and identification of indomethacin arginine and lysine salts. Acta Pharm. Turc., 1981, 23, 10-15.
16. Topaloglu Y., Yener G., Gonullu U.: Inclusion of ketoprofen with skimmed milk by freeze-drying. Farmaco, 1999, 54, 648-652.
17. Topaloglu Y., Yener G., Kavalali G.: Investigations on anti-inflammatory activity of solid dispersion of indomethacin prepared with skimmed milk. Acta Pharm. Turc., 1998, 40, 13-17.
18. Vademecum, Modern Ilac Rehberi (Modern Drug Guide), Riza Ommaty, Ankara, Feryal Matbaasi, 2002.
19. Winter C.A., Risley E.A., Nuss G.W.: Carrageenan-induced edema in the hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med., 1962, 111, 544-547.