Efficacy and tolerability of delapril plus indapamide versus lisinopril plus hydrochlorothiazide combination treatments in mild to moderate hypertension: A multicenter, randomized clinical study

Current Therapeutic Research - Clinical and Experimental

Volumn 64, Issue 5, 2003, Pages 290-300

  Cremonesi, Giovanni ^a   Cavalieri, Luca ^a   Bacchelli, Stefano ^b,f   Esposti, Daniela Degli ^b   Cikes, Ivo ^c   Dobovisek, Jurij ^d   Zeman, Jan ^e   Borghi, Claudio ^b   Ambrosioni, Ettore ^b  

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF ZAGREB   (Croatia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e CHARLES UNIVERSITY   (Czech Republic)

^f UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Combination therapy; Delapril; Hydrochlorothiazide; Hypertension; Indapamide; Lisinopril

Indexed keywords

ADRENALIN; CAPTOPRIL; DELAPRIL; DELAPRIL PLUS INDAPAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DRUG METABOLITE; ENALAPRIL; HYDROCHLOROTHIAZIDE PLUS LISINOPRIL; INDAPAMIDE; NORADRENALIN; PLACEBO; PROSTAGLANDIN E2; THIAZIDE DIURETIC AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DRUG ABSORPTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG UTILIZATION; ENZYME INHIBITION; FATIGUE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALAISE; MALE; MULTICENTER STUDY; OUTCOMES RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SITTING; SKIN DISEASE; SYSTOLIC BLOOD PRESSURE; TABLET; VERTIGO;

EID: 0038779654     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(03)00084-5     Document Type: Article

References (18)

1. Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838.
2. Staessen JA, Wang JG, Thijs L. Cardiovascular protection and blood pressure reduction: A meta-analysis. Lancet. 2001;358:1305-1315.
3. Guidelines Subcommittee. 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens. 1999; 17:151-183.
4. Hansson L, Zanchetti A, Carruthers SG, et al., for the HOT Study Group. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet. 1998;351:1755-1762.
5. Mancia G, Carugo S, Grassi G, et al. Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control: Data from the PAMELA population. Pressioni Arteriose Monitorate E Loro Associazioni. Hypertension. 2002;39:744-749.
6. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288:2981-2997.
7. Rappelli A. Controlling hypertension: Lisinopril-hydrochlorothiazide vs captopril-hydrochlorothiazide. An Italian multicentre study. J Hum Hypertens. 1991;5(Suppl 2): 55-57.
8. Bevilacqua M, Vago T, Rogolino A, et al. Affinity of angiotensin I-converting enzyme (ACE) inhibitors for N- and C-binding sites of human ACE is different in heart, lung, arteries, and veins. J Cardiovasc Pharmacol. 1996;28:494-499.
9. Plante GE, Dessurault DL. Hypertension in elderly patients. A comparative study between indapamide and hydrochlorothiazide. Am J Med. 1988;84(Suppl 1B):98-103.
10. Gambardella S, Frontoni S, Pellegrinotti M, et al. Carbohydrate metabolism in hypertension: Influence of treatment. J Cardiovasc Pharmacol. 1993;22(Suppl 6):S87-S97.
11. Ames RP. A comparison of blood lipid and blood pressure responses during the treatment of systemic hypertension with indapamide and with thiazides. Am J Cardiol. 1996;77:12b-16b.
12. Poli G, Acerbi D, Ventura P, Hutt V. Pharmacokinetics of delapril and indapamide after single and repeated administration in healthy volunteers. Blood Press. 1994; 3(Suppl):17S-25S.
13. Hutt V, Pabst G, Dilger C, et al. Bioavailability and pharmacokinetics of a fixed combination of delapril/indapamide following single and multiple dosing in healthy volunteers. Eur J Drug Metab Pharmacokinet. 1994;19:59-69.
14. Rappelli A, Dessi Fulgheri P, Agabiti-Rosei E, et al. Delapril and indapamide combination therapy in hypertensive patients: A double-blind randomized multicenter study. Blood Press. 1994;3(Suppl):34S-38S.
15. Leonetti G, on behalf of the DIMS investigators. Delapril-lndapamide Multicenter Study (DIMS) [in Italian]. Cardiologia. 1997;42(Suppl):401S-406S.
16. Rosei EA, Rizzoni D. Evaluation of the efficacy and tolerability of the combination delapril plus indapamide in the treatment of mild to moderate essential hypertension: A randomised, multicentre, controlled study. J Hum Hypertens. 2003;17: 139-146.
17. Rosiello G, Tozzi N, Sarno D, et al. Safety and tolerability of long-term treatment with delapril-indapamide combination in patients with mild to moderate hypertension. Blood Press. 1994;3(Suppl):74S-79S.
18. Ambrosioni E, Borghi C, Costa FV. Captopril and hydrochlorothiazide: Rationale for their combination. Br J Clin Pharmacol. 1987;23(Suppl 1):43S-50S.