IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1

FEMS Microbiology Letters

Volumn 223, Issue 2, 2003, Pages 199-203

  Im, Yang Ju ^a   Idkowiak Baldys, Jolanta ^a   Thevissen, Karin ^b   Cammue, Bruno P A ^b   Takemoto, Jon Y ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cyclic lipodepsipeptide; DmAMP1; Mannosyldiinositolphosphoceramide; Plant defensin; Saccharomyces cerevisiae; Sphingolipid; Syringomycin E

Indexed keywords

ANTIFUNGAL AGENT; CERAMIDE DERIVATIVE; CYCLODEPSIPEPTIDE; DEFENSIN; GLUCOSE; MANNOSYLDIINOSITOL PHOSPHOCERAMIDE; SPHINGOLIPID; SYRINGOMYCIN E; TRANSFERASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DELETION MUTANT; FUNGAL GENE; FUNGICIDAL ACTIVITY; FUNGUS GROWTH; GENE DELETION; GENE EXPRESSION; GENETIC CODE; LIPOGENESIS; NONHUMAN; POTATO; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SOLANUM TUBEROSUM;

EID: 0038771937     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(03)00375-6     Document Type: Article

References (17)

1. Takemoto, J.Y., Brand, J.G., Kaulin, Y.A., Malev, V.V., Schagina, L.V. and Blasko, K. (2003) The syringomycins: lipodepsipeptide pore formers from plant bacterium, Pseudomonas syringae. In: Pore Forming Peptides and Protein Toxins (Menestrina, G., Serra, M.D. and Lazarovici, P., Eds.), pp. 260-271. Taylor and Francis, London.
2. Batoko H., Bouharmont J., Kinet J.M., Maraite H. Involvement of toxins produced by Pseudomonas fuscovaginae in aetiology of. J. Phytopathol.-Phytopathol. Z. 145:1997;525-531.
3. Bender C.L., Alarcon-Chaidez F., Gross D.C. Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiol. Mol. Biol. Rev. 63:1999;266-292.
4. Stock S.D., Hama H., Radding J.A., Young D.A., Takemoto J.Y. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob. Agents Chemother. 44:2000;1174-1180.
5. Thevissen K., Cammue B.P.A., Lemaire K., Winderickx J., Dickson R.C., Lester R.L., Ferkert K.K.A., Van Even F., Parret A.H.A., Broekaert W.F. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc. Natl. Acad. Sci. USA. 97:2000;9531-9536.
6. Thomma B.P., Cammue B.P., Thevissen K. Plant defensins. Planta. 216:2002;193-202.
7. Thevissen K., Terras F.R., Broekaert W.F. Permeabilization of fungal membranes by plant defensins inhibits fungal growth. Appl. Environ. Microbiol. 65:1999;5451-5458.
8. Dickson R.C., Lester R.L. Sphingolipid functions in Saccharomyces cerevisiae. Biochim. Biophys. Acta. 1583:2002;13-25.
9. Dickson R.C., Nagiec E.E., Wells G.B., Nagiec M.M., Lester R.L. Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem. 272:1997;29620-29625.
10. Bidwai A.P., Zhang L., Bachmann R.C., Takemoto J.Y. Mechanism of action of Pseudomonas syringae phytotoxin, syringomycin. Stimulation of red beet plasma membrane ATPase activity. Plant Physiol. 83:1987;39-43.
11. Osborn R.W., De Samblanx G.W., Thevissen K., Goderis I., Torrekens S., Van Leuven F., Attenborough S., Rees S.B., Broekaert W.F. Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 368:1995;257-262.
12. Smith S.W., Lester R.L. Inositol phosphorylceramide, a novel substance and the chief member of a major group of yeast sphingolipids containing a single inositol phosphate. J. Biol. Chem. 249:1974;3395-3405.
13. Steiner S., Lester R.L. Studies on the diversity of inositol-containing yeast phospholipids: incorporation of 2-deoxyglucose into lipid. J. Bacteriol. 109:1972;81-88.
14. Stock S.D., Hama H., DeWald D.B., Takemoto J.Y. SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production. J. Biol. Chem. 274:1999;12979-12983.
15. Takemoto J.Y., Yu Y., Stock S.D., Miyakawa T. Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. FEMS Microbiol. Lett. 114:1993;339-342.
16. Thevissen K., Osborn R.W., Acland D., Broekaert W.F. Specific binding sites for an antifungal plant defensin from Dahlia (Dahlia merckii) on fungal cells are required for antifungal activity. Mol. Plant-Microbe Interact. 13:2000;54-61.
17. Malev V.V., Schagina L.V., Gurnev P.A., Takemoto J.Y., Nestorovich E.M., Bezrukov S.M. Syringomycin E channel: a lipidic pore stabilized by lipopeptide? Biophys. J. 82:2002;1985-1994.