Antibacterial properties of gemifloxacin and trovafloxacin in urine ex vivo: Phase I study

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 6, 2001, Pages 1876-1878

  García Calvo, Gloria ^a   Parra, Araceli ^a   Aguilar, Lorenzo ^b   Ponte, Carmen ^a   Giménez, María J ^b   Carcas, Antonio ^c   Kinzig Schippers, Martina ^d   Soriano, Francisco ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^b GLAXOSMITHKLINE   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d IBMP   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GEMIFLOXACIN; TROVAFLOXACIN;

ADULT; ANTIBIOTIC SENSITIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BIOASSAY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG URINE LEVEL; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; FLUOROQUINOLONES; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; NAPHTHYRIDINES; STAPHYLOCOCCUS;

EID: 0038735259     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.6.1876-1878.2001     Document Type: Article

References (6)

1. Aguilar, L., I. P. Balcabao, P. Salvá, M. Martin, J. Costa, J. Prieto and R. Dal-Ré. 1996. Ex vivo antibacterial properties of rufloxacin compared with those of norfloxacin in a study with healthy volunteers. Antimicrob. Agents Chemother. 40:17-21.
2. Cruciani, M., V. Monzillo, A. Navarra, C. Tinelli, and E. Concia. 1988. Antibacterial activity of norfloxacin, ofloxacin and pipemidic acid detected in urine of volunteers. Drugs Exp. Clin. Res. 14:533-537.
3. Drusano, G., H. Standiford, P. Ryan, W. McNamee, B. Tatem, and S. Schimpff. 1986. Correlation of predicted serum bactericidal activities and values measured in volunteers. Eur. J. Clin. Microbiol. 5:88-92.
4. Klasterky, J., D. Daneau, G. Swings, and D. Weerts. 1974. Antibacterial activity in serum and in urine as a therapeutic guide in bacterial infections. J. Infect. Dis. 129:187-193.
5. National Committee for Clinical Laboratory Standards. 1985. Methods for dilution antimicrobial susceptibility tests for bacteria which grow aerobically. Approved standard M7-A. National Committee for Clinical Laboratory Standards, Villanova, Pa.
6. Norrby, S. R. 1993. Treatment of urinary tract infections with quinolone antimicrobial agents, p. 273-283. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antimicrobial agents. American Society for Microbiology, Washington, D.C.