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Volumn 301, Issue 5629, 2003, Pages 66-70

Control of axon branch dynamics by correlated activity in vivo

Author keywords

[No Author keywords available]

Indexed keywords

BINOCULAR VISION; OPTICAL CORRELATION; PROBABILITY;

EID: 0038724939     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082545     Document Type: Article
Times cited : (219)

References (40)
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    • 0038402188 scopus 로고    scopus 로고
    • note
    • Materials and methods are available as supporting material on Science Online.
  • 22
    • 0038740337 scopus 로고    scopus 로고
    • note
    • Previous data show that a 2-hour imaging interval underestimates the total number of rapid branch rearrangements, but it greatly reduces the risk of phototoxicity. It also ensured that animals received considerable natural visual experience during the intervals between image collection. Imaging and full recovery from anesthesia require about 15 min. Thus, the tadpoles spent at least 85% of the experimental period swimming and experiencing natural vision.
  • 23
    • 0038063901 scopus 로고    scopus 로고
    • note
    • All values are presented as the mean ± SEM.
  • 24
    • 0038740338 scopus 로고    scopus 로고
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    • This analysis also allowed us to exclude the possibility that the results seen in ipsilateral axons may have been due to the contribution of a population of regenerating ipsilateral axons that were potentially severed during tectal surgery.
  • 26
    • 0038063897 scopus 로고    scopus 로고
    • note
    • The overall contralateral bias of inputs is reflected in the mean local ocular dominance of MK-801-treated branch tips (Fig. 6B), but does not severely affect the comparison between branch behaviors in ipsilaterally dominated and contralaterally dominated territories (Fig. 6, C and D)
  • 39
    • 0038063899 scopus 로고    scopus 로고
    • note
    • n = 409 contra untreated, 408 ipsi untreated, 168 contra MK-801-treated, 224 ipsi MK-801-treated branch tips. n (lost, added, transient, stabilized) for contra axons = (59, 49, 25, 24) in five animals, n for ipsi axons = (58, 87, 34, 53) in five animals.
  • 40
    • 0038063902 scopus 로고    scopus 로고
    • note
    • Supported by the NIH (E.S.R., H.T.C.), Helen Hoffritz Foundation (H.T.C.), and a Wellcome Trust International Fellowship (C.J.A). We thank S. Kaell and J. Pinezich of Advanced Acoustic Concepts for help with the computer simulation; K. Svoboda, B. Burbach, and P. O'Brien for guidance in constructing the two-photon microscope; M. Stryker for comments on the manuscript; and the members of the Cline laboratory for comments on the manuscript and constructive discussions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.