Development of a liquid chromatographic/tandem mass spectrometric assay for a new endothelin receptor antagonist, and its application to dog plasma samples generated after simultaneous i.v. and p.o. administration of the unlabeled and deuterium-labeled forms of this antagonist

Journal of Mass Spectrometry

Volumn 38, Issue 6, 2003, Pages 649-658

  Lausecker, Berthold ^a   Fischer, G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Bioavailability; Endothelin receptor antagonist; Fragmentation; Liquid chromatography tandem mass spectrometry; Quantification; Stable isotope

Indexed keywords

DEUTERIUM; DRUG THERAPY; ION EXCHANGE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PRECIPITATION (CHEMICAL); PROTEINS;

SOLID-PHASE EXTRACTION (SPE);

BIOASSAY;

5 HYDROXYMETHYLPYRIMIDINE 2 SULFONIC ACID [6 METHOXY 5 (2 METHOXYPHENOXY) 2 PYRIDIN 4 YLPYRIMIDIN 4 YL]AMIDE; 5 METHYLPYRIDINE 2 SULFONIC ACID [6 METHOXY 5 (2 HYDROXYPHENOXY) 2 PYRIDIN 4YLPYRIMIDIN 4 YL]AMIDE; 5 METHYLPYRIDINE 2 SULFONIC ACID [6 METHOXY 5 (2 METHOXYPHENOXY) 2 PYRIDIN 4 YLPYRIMIDIN 4 YL]AMIDE; DEUTERIUM; DRUG METABOLITE; ENDOTHELIN RECEPTOR ANTAGONIST; METHYL GROUP; RO 670565; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; NONHUMAN; OPTICAL RESOLUTION; PRECIPITATION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM; DOGS; ENZYME INHIBITORS; INJECTIONS, INTRAVENOUS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; RECEPTORS, ENDOTHELIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

CANIS FAMILIARIS;

EID: 0038724606     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.479     Document Type: Article

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