Alternative methods for acute oral toxicity testing: Practical guidance for implementation

Lab Animal

Volumn 31, Issue 7, 2002, Pages 42-48

  Rispin, Amy ^a   McCall, Deborah ^a   Farrar, David ^a   Margosches, Elizabeth ^a   Gupta, Kailash ^b   Stitzel, Katherine ^c   Carr, Gregory ^c   Greene, Michael ^b   Rogers, John ^d   Meyer, William ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b United States Consum Prod S   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d WESTAT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE TOXICITY; AGE DISTRIBUTION; ANIMAL CARE; ANIMAL WELFARE; BODY WEIGHT; CALCULATION; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONFIDENCE INTERVAL; LD 50; MEDICAL DOCUMENTATION; MOUTH; NONHUMAN; PRACTICE GUIDELINE; REVIEW; SEX RATIO; TIME; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMAL TESTING ALTERNATIVES; ANIMAL WELFARE; ANIMALS; ANIMALS, LABORATORY; HUMANS; LETHAL DOSE 50; PRACTICE GUIDELINES; TOXICITY TESTS;

ANIMALIA;

EID: 0038717379     PISSN: 00937355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (13)

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2. Organisation for Economic Cooperation and Development. OECD Test Guideline 401: Acute Oral Toxicity. (OECD, Paris, France, 1987).
3. th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals. (OECD, Paris, France, 1999).
4. Organisation for Economic Cooperation and Development. OECD Guidelines for the Testing of Chemicals. Guideline 420: Acute Oral Toxicity - Fixed Dose Procedure; Guideline 423: Acute Oral Toxicity - Acute Toxic Class Method; Guideline 425: Acute Oral Toxicity - Up-and-Down Procedure. (Paris, France, 2001).
5. Stallard, N., Whitehead, A. & Ridgeway, P. Statistical evaluation of the fixed dose procedure. Hum. Exp. Toxicol. (2002), in press.
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8. Interagency Coordinating Committee on the Validation of Alternative Methods and National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods. The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals. NIH Publication No. 02-4501. (NIEHS, Research Triangle Park, NC, 2001). http://iccvam.niehs.nih.gov/methods/udp-docs/udpfin/vol_1.pdf and http://iccvam.niehs.nih.gov/methods/udp-docs/udpfin/vol_2.pdf.
9. United States Environmental Protection Agency. Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP). Review of Applicability of the Up and Down Procedure Methodology for Acute Oral Toxicity Testing. Final panel report. 2001. http://www.epa.gov/scipoly/sap/2001/index_html.
10. Westat, Inc. Acute Oral Toxicity Software Program: AOT425StatPgm; User Documentation for the AOT425StatPgm Program; Simulation Results for the AOT425StatPgm Program; and QA Testing for the AOT425StatPgm Program. Report prepared for EPA under Contract 68-W7-0025, Task Order 5-03. (Rockville, MD, 2001).
11. Organisation for Economic Cooperation and Development. Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation. OECD Series on Testing and Assessment No. 19. (OECD, Paris, France, 2000).
12. Organisation for Economic Cooperation and Development. Guidance Document on Acute Oral Toxicity Testing. OECD Series on Testing and Assessment No. 24. (OECD, Paris, France, 2001).
13. Dixon, W.J. Staircase bioassay: the up-and-down method. Neurosci. Biobehav. Rev. 15, 47-50 (1991).