Treatment of depressive symptoms with quetiapine

Expert Review of Neurotherapeutics

Volumn 3, Issue 4, 2003, Pages 417-423

  Kasper, Siegfried ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Atypical antipsychotic; Bipolar disorder; Depression; Mania; Psyshosis; Quetiapine; Schizophrenia

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; LITHIUM; LITHIUM CARBONATE; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; VALPROATE SEMISODIUM;

ADD ON THERAPY; BIPOLAR DISORDER; BODY WEIGHT DISORDER; CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; EXTRAPYRAMIDAL SYMPTOM; HUMAN; HYPERPROLACTINEMIA; MANIA; MENSTRUATION DISORDER; MONOTHERAPY; MOTOR DYSFUNCTION; PSYCHOSIS; RAPID CYCLING BIPOLAR DISORDER; REVIEW; SCHIZOPHRENIA; SEXUAL DYSFUNCTION; WEIGHT GAIN;

EID: 0038715318     PISSN: 14737175     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737175.3.4.417     Document Type: Review

References (29)

1. Kasper S, Müller-Spahn F. Review of quetiapine and its clinical applications in schizophrenia. Expert Opin. Pharmacother. 1, 783-801 (2000). Recent review on quetiapine in schizophrenia.
2. Martin RL, Cloninger CR, Guze SB, Clayton PJ. Frequency and differential diagnosis of depressive syndromes in schizophrenia. J. Clin. Psychiatry 46, 9-13 (1985).
3. Wassink TH, Flaum M, Nopoulos P, Andreasen NC. Prevalence of depressive symptoms early in the course of schizophrenia. Am. J. Psychiatry 156, 315-316 (1999).
4. Keck PE Jr, Strakowski SM, McElroy SL. The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility and suicidality in patients with schizophrenia. J. Clin. Psychiatry 61(Suppl. 3), 4-9 (2000).
5. Regier DA, Farmer ME, Rae DS et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264, 2511-2518 (1990).
6. Koreen AR, Siris SG, Chakos M, Alvir J, Mayerhoff D, Lieberman J. Depression in first-episode schizophrenia. Am. J. Psychiatry 150, 1643-1648 (1993).
7. Roy A, Thompson R, Kennedy S. Depression in chronic schizophrenia. Br. J. Psychiatry 142, 465-470 (1983).
8. AstraZeneca Pharmaceuticals. Data on file.
9. Tollefson GD, Sanger TM, Lu Y, Thieme ME. Depressive signs and symptoms in schizophrenia: a prospective blinded trial of olanzapine and haloperidol. Arch. Gen. Psychiatry 55, 250-258 (1998).
10. Ghaemi SN. New treatments for bipolar disorder: the role of atypical neuroleptic agents. J. Clin. Psychiatry 61 (Suppl. 14), 33-42 (2000).
11. Saller CF, Salama AI. Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl). 112, 285-292 (1993).
12. Small JG, Hirsch SR, Arvanitis LA, Miller BG, Link CG. Quetiapine in patients with schizophrenia. A high- and low-dose double-blind comparison with placebo. Seroquel Study Group. Arch. Gen. Psychiatry 54, 549-557 (1997). Clinical trial that assessed efficacy and safety of quetiapine in schizophrenia patients. This included the effect of quetiapine on depressive symptoms.
13. Sajatovic M, Brescan DW, Perez DE et al. Quetiapine alone and added to a mood stabilizer for serious mood disorders. J. Clin. Psychiatry 62, 728-732 (2001). This study examined the effect of quetiapine on depressive symptoms in patients with mood disorders.
14. Arvanitis LA, Miller BG. Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia: a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Biol. Psychiatry 42, 233-246 (1997). Double-blind, randomized, controlled trial that assessed efficacy and safety of quetiapine in schizophrenia patients. This included the effect of quetiapine on depressive symptoms.
15. Mullen J, Jibson MD, Sweitzer D. A comparison of the relative safety, efficacy and tolerability of quedapine and risperidone in outpatients with schizophrenia and other psychotic disorders: the quetiapine experience with safety and tolerability (QUEST) study. Clin. Ther. 23, 1839-1854 (2001). Compares the efficacy and safety of quetiapine and risperidone in patients with schizophrenia and includes an assessment of the effects of these drugs on depressive symptoms.
16. Tauscher-Wisniewski S, Kapur S, Tauscher J et al. Quedapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade. J. Clin. Psychiatry 63, 992-997 (2002).
17. Buckley PE Broad therapeutic uses of atypical antipsychotic medications. Biol. Psychiatry 50, 912-924 (2001).
18. Keck PE Jr. What makes a drug a primary mood stabilizer? Mol. Psychology 7(Suppl. 1), S8-S14 (2002).
19. Khouzam HR. Treatment of depressive mood in schizophrenia with the atypical antipsychotic quetiapine. Depress. Anxiety 11, 80-82 (2000). Discusses two cases of patients with schizophrenia whose depressive symptoms improved with quetiapine treatment.
20. Emsley RA, Rankvalla J, Bailey PJ, Jones AM. A comparison of the effects of quetiapine ('Seroquel') and haloperidol in schizophrenic patients with a history of and a demonstrated, partial response to conventional andpsychotic treatment. PRIZE Study Group. Int. Clin. Psychopharmacol. 15, 121-131 (2000). The first international, randomized, double-blind study to compare quetiapine with haloperidol in patients with schizophrenia (includes data on their effects on depressive symptoms).
21. Irmansyah, Jones AM, Whiteford JL, Altman C. Switching patients to quetiapine improves depressive symptoms in schizophrenia. Int. J. Neuropsychopharmacol. 5(Suppl. 1), 122 (2002).
22. Sajatovic M, Mullen JA, Sweitzer DE. Efficacy of quetiapine and risperidone against depressive symptoms in outpatients with psychosis. J. Clin. Psychiatry 63, 1156-1163 (2002). Directly compares the efficacy of quetiapine and risperidone on depressive symptoms in patients with psychosis and one of several DSM-IV diagnoses, including independent data on bipolar disorder
23. Brown ES, Nejtek VA, Perantie DC, Bobadilla L. Quetiapine in patients with bipolar disorder and cocaine dependence. Bipolar Disord. 4, 406-411 (2002). First study to address treatment of patients with bipolar disorder and comorbid substance (cocaine) dependence with quetiapine.
24. Goodwin FK, Jamison KR, Manic-Depressive Illness. Oxford University Press, NY, USA (1990).
25. Chisholm K, Dennehy E, Suppes T. Clinical response to quetiapine add-on for treatment of refractory bipolar disorder. Paper presented at: 4th International Conference on Bipolar Disorder, Pittsburgh, PA, USA (2001).
26. Zarate CA Jr, Rothschild A, Fletcher KE, Madrid A, Zapatel J. Clinical predictors of acute response with quetiapine in psychotic mood disorders. J. Clin. Psychiatry 61, 185-189 (2000).
27. Keck PE Jr, Syllabus and proceedings summary of the APA meeting. New Orleans, LA, USA, May 5-10, 93 (Abstract 34E) (2001).
28. Sachs G, Mullen JA, Devine NA, Sweitzer DE. Quetiapine versus placebo as adjunct to mood stabilizer for the treatment of acute mania. Bipolar Disord 4(Suppl. 1), 133 (2002). First report of a large, randomized, double-blind clinical trial of adjunctive treatment with quetiapine in patients with bipolar disorder. Includes assessment of the effect of quetiapine on depressive symptoms.
29. Geddes J, Freemande N, Harrison P, Bebbington P. Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis. Br. Med. J. 321, 1371-1376 (2000).