Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis

Journal of Experimental and Clinical Cancer Research

Volumn 22, Issue 2, 2003, Pages 201-212

  Rajeshkumar, N V ^a   Radahakrishna Pillai, M ^b   Kuttan, Ramadasan ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

^b REGIONAL CANCER CENTRE   (India)

Author keywords

Apoptosis; Emblica officinalis; Hepatic tumour; N nitrosodiethylamine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILIRUBIN; DIETHYLNITROSAMINE; DNA TOPOISOMERASE; EMBLICA OFFICINALIS EXTRACT; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROXYL RADICAL; POLYPHENOL DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; SUPEROXIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASCITES CELL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CANCER CELL CULTURE; CANCER MODEL; CELL LINE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; EMBLICA OFFICINALIS; ENZYME ACTIVITY; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER TUMOR; LIVER WEIGHT; MALE; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARCINOGENS; CDC25 PHOSPHATASE; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIPID PEROXIDATION; LIVER NEOPLASMS; MALE; MICE; NEOPLASMS; ORGAN SIZE; PHENOLS; PHYLLANTHUS EMBLICA; RATS; RATS, WISTAR; SACCHAROMYCES CEREVISIAE; SUPEROXIDES;

EID: 0038714506     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Zaman H. The South-East Asia. In: Banner-man RH (Ed) Traditional Medicine. World Health Organization. Geneva, 1974.
2. Roy A.K., Dhir H., Sharma A., Talukder G.: Phyllanthus emblica fruit extract and ascorbic acid modify hepatotoxic and renotoxic effects of metals in mice. Int. J. Phamacog. 29: 117-126, 1991.
3. Agarwal K., Dhir H., Sharma A., Talukder G.: The efficacy of two species of Phyllanthus in counteracting nickel clastogenicity. Fitoterapia. 63: 49-54, 1992.
4. Jose J.K., Joy K.L., Kuttan R.: Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 135: 1-6, 1999.
5. El-Mekkawy S., Meselhy M.R., Kusumoto I.T., Kadota S., Hattori M., Nmba T.: Inhibitory effect of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem. Pharm. Bull. 43, 641-648, 1995.
6. Nandi P., Talukder E., Sharma A.: Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn fruit extract. Br. J. Cancer. 76: 1279-1283, 1997.
7. Sharma N., Trikha P., Athar M., Raisuddin S.: In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis. Drug Chem. Toxicol. 23: 477-484, 2000.
8. Jose J.K., Kuttan G., George J., Kuttan R.: Antimutagenic and anticarcinogenic activity of Emblica officinalis Gaertn. J. Clin. Biochem. Nutr 22: 171-176, 1997.
9. Grover I.S., Kaur S.: Effect of Emblica officinalis Gaertn (Indian gooseberry) fruit extract on sodium azide and 4-nitro-O-phenylenediamine-induced mutagenesis in Salmonella typhimurium. Ind. J. Exp. Biol. 27: 207-209, 1989.
10. Suresh K., Vasudevan D.M.: Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulatory. J. Ethnopharmacol. 44: 55-60, 1994.
11. Rajeshkumar N.V., Therese M., Kuttan R.: Emblica officinalis fruit afford protection against experimental gastric ulcers in rats. Pharmaceutical Biol. 39: 375-380, 2001.
12. Jose J.K., Kuttan R.: Hepatoprotective activity of Emblica officinalis and Chyavanaprash. J. Ethnopharmacol. 72: 135-140, 2000.
13. Sharma N., Trikha P., Athar M., Raisuddin S.: Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice. Hum. Exp. Toxicol. 19: 377-384, 2000.
14. Jose J.K., Kuttan R.: Antitumour activity of Emblica officinalis. J. Ethnopharmacol. 75: 65-69, 2001.
15. Harbome J.B.: In: Phytochemical methods. Harbome JB (Ed) Chapman and Hall, London, 33-34, 1976.
16. McCord J.M., Fridovich I.: Superoxide dismutase: an enzymatic function for erythrocuprein. J. Biol Chem. 244: 6049-6055, 1969.
17. Ohkawa H., Ohishi N., Yagi K.: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Ann. Biochemistry. 95: 351-358, 1979.
18. Bishayee S., Balasubramanian A. S.: Assay of lipid peroxide formation. J. Neurochem. 18: 909-920, 1971.
19. Chang Y.C., Nair M. G., Nittis J.L.: Metabolites of daidzein and genistein and their biological ativities. J. Nat. Prod. 58: 1901-1905, 1995.
20. Roth G.N., Chandra A., Nair M.G.: Novel bioactivities of Curcuma longa constituents. J. Nat. Product 61: 542-545, 1998.
21. cdc13protein kinase. Anticancer Res. 12: 873-880, 1992.
22. Narurkar L.M., Narurker M.V.: Role of nicotinamide in suppression of diethylnitrosamine hepatocarcinogenesis in rats. In: Bhide S.V., Maru, G.B (Eds) Chemoprevention of cancer. Omega Scientific Publishers, New Delhi. 162-177, 1989.
23. Rajeshkumar N.V., Kuttan R.: Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. J. Exp. Clin. Cancer Res. 19: 459-465, 2000.
24. Lowry H.D., Rosenberg N.J., Fair A.L., Randu R.J.: Protein measurement with Folin phenol reagent. J. Biol Chem. 193: 265-275, 1951.
25. Szaz G.: Reaction rate method for gamma glutamyl transferase activities in serum. Clinical Chem. 22: 2031-2055, 1976.
26. Tate S.S., Meister A.: Interaction of gamma glutamyl transpeptidase with amino acids, peptides and derivatives and analogues of glutathione. J. Biol. Chem. 23: 7593-7602, 1974.
27. Haibig W.H., Pabst M.J., Jakoby W.R.: Glutathione S-transferase, the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249: 7130-7139,1974.
28. Moron M.A., Depicrre J.W., Mannervick B.: Levels of glutathione, glutathione S-transferase activities in rat liver. Biochem Biophys Acta. 582: 67-68, 1979.
29. King E.J., Armstrong A.R.: Method of King and Armstrong In: Varley H., Gowenlock A.H., Bell M. (Eds) Practical Clinical Biochemistry, William Heinemann, London, p. 897-899, 1980.
30. Bergmeyer H.O., Bemt E.: Calorimetric method for aspartate and alanine amino transferases In: Varley H, Gowenlock, AH, Bell, M (Eds) Practical Clinical Biochemistry, Vol. 1. William Heinemann, London, pp. 741-742, 1980.
31. Jose J.K., Kuttan R.: Antioxidant activity of Emblica officinalis. J. Clin Biochem. Nutr. 19: 67-70, 1995.
32. Elizabeth K., Rao M.N.A.: Oxygen radical scavenging of Curcumin. Int J Pharmaceutics. 58: 237-240, 1990.
33. Hanigan M.H., Pitot H.C.: Gamma-glutamyl transpeptidase-its role in hepatocarcinogenesis. Carcinogenesis 6: 1655-1672, 1985.
34. Wild C.P., Hall A.J.: Primary prevention of hepatocellular carcinoma in developing countries. Mutat. Res. 462: 381-393, 2000.
35. El-Serag H., Manson A.C.: Rising incidence of hepatocellular carcinoma in the United States. N. Eng. J. Med. 340, 745-750, 1999.
36. Hasegawa S., Yamasaki N., Hiwaki T., Sako K., Komarizona O., Yoshida A., Arima T.: Factors that predict intra hepatic recurrence of HCC in 81 patients initially treated by precutaneous ethanol injection. Cancer. 86: 1682-1690, 1999.
37. Okuda K., Fugimoto I., Hanai K., Urano Y.: Changing incidence of hepatocellular carcinoma in Japan. Cancer Res. 47: 4967-4972, 1987.
38. Kew M.C.: Hepatic tumours and cysts. In: Feldman, M., Sleisenter M.H., Scharschmidt B.F (Eds) Sleisenger and Fordtran's gastroenterology and liver disease: pathology/diagnosis/management. Philadephia. Sunders. 1364-1387, 1998.
39. Mazzaferro V., Regalia E., Doci R., Andreola S., Pulvirenti A., Bozzetti F.: Liver transplantation for the treatment of small hepatocellular carcinoma in patients with cirrhosis. N. Eng. J. Med. 334: 693-699, 1996.
40. Okuda K.: Hepatocellular carcinoma. J. Hepatology 32: (Suppl I) 225-237, 2000.
41. Ghosh S.S., Takahashi M., Thummala N.R., Parasshar B., Chowdhury N.R., Chowdhury J.R.: Liver directed gene therapy: promises, problems and prospects at the turn of the century. J. Hepatology 32 (Suppl.1), 238-252, 2000.
42. D'Arpa Liu L.F.: Topoisomerase-targeting antitumour drugs. Biochemica et Biophysica Acta. 989: 163-177, 1989.
43. Gellert M.: DNA topoisomerases. Ann. Rev. Biochem. 50: 879-910, 1981.
44. Chow K.C., Macdonald T.L., Ross W.E.: DNA binding by epipodophyllotoxins and N-acyl anthracyclins: implications for mechanism of topoisomerase II inhibition. Mol. Pharmacol. 34: 467-473, 1988.
45. Liu L.F:. DNA topoisomerase poisons as antitumour drugs. Ann. Rev. Biochem. 58: 351-375, 1989.
46. Brusch W., Oberhammer F., Schylte-Hermann R.: Cell death by apoptosis and its protective role against disease. Trends Pharmacol. Sci. 13: 245-251, 1992.
47. Smets L.A.: Programmed cell death (apoptosis) and response to anti-cancer drugs. Anti Cancer Drugs. 5: 3-9, 1994.
48. Diomede L., Piovani M., Re F., Principe P., Colotta F., Modest E.J., Salmona M.: The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in human leukemic cells. Int. J. Cancer. 57: 645-649, 1994.
49. Zhao Y., Cao J., Ma H., Liu J.: Apoptosis induced by green tea polyphenols in HL-60 cells. Cancer Lett. 121: 163-167, 1997.
50. Paschka A.G., Butler R., Young C.Y.F.: Induction of apoptosis in prostate cancer cell lines by the green tea component, epigallocatechin gallate. Cancer Lett. 130: 1-7, 1998.
51. Chung L.Y., Cheung T.C., Kong S.K., Fung K.P., Choy Z.M., Chan Z.Y., Kwok T.T.: Induction of apoptosis by green tea catechins in human prostrate cancer DU 145 cells. Life Sciences, 68: 1207-1214, 2001.
52. Jose J.K., Kuttan R., Bhattacharya R.K.: Effect of Emblica offficinalis extract on hepatocarcinogenesis and carcinogen metabolism. J. Clin. Biochem. Nutr. 25: 31-39, 1998.