Longevity and carrying the C282Y mutation for haemochromatosis on the HFE gene: Case control study of 492 French centenarians

BMJ

Volumn 327, Issue 7407, 2003, Pages 132-133

  Coppin, Hélène ^a   Bensaid, M ^a   Fruchon, S ^a   Borot, N ^a   Roth, M ^a   Blanche H ^b  

^a CHU PURPAN   (France)

^b FONDATION JEAN DAUSSET CEPH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IRON; TRANSFERRIN;

AGED; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; FRANCE; GENE AMPLIFICATION; GENE MUTATION; GERIATRIC PATIENT; HEMOCHROMATOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IRON METABOLISM; LONGEVITY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; FRANCE; HEMOCHROMATOSIS; HETEROZYGOTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMANS; LONGEVITY; MALE; MEMBRANE PROTEINS; MUTATION;

EID: 0038714006     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.327.7407.132     Document Type: Article

References (5)

1. Fuchs J, Podda M, Packer L, Kaufmann R. Morbidity risk in HFE associated hereditary hemochromatosis C282Y heterozygotes. Toxicology 2002; 180: 169–81.
2. Worwood M. HFE Mutations as risk factors in disease. Best Pract Res Clin Haematol 2002; 15: 295–314.
3. Blanche H, Cabanne L, Sahbatou M, Thomas G. A study of French centenarians: are ACE and APOE associated with longevity? C R Acad Sci III 2001; 324: 129–35.
4. Fruchon S, Bensaid M, Borot N, Roth MP, Coppin H. Use of denaturing HPLC and a heteroduplex generator to detect the HFE C282Y mutation associated with genetic hemochromatosis. Clin Chem 2003; 49: 822–4.
5. Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845G– > A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002; 359: 211–8.