Codeine and morphine blood concentrations increase during blood loss

Journal of Forensic Sciences

Volumn 48, Issue 3, 2003, Pages 664-667

  Kugelberg, Fredrik C ^a   Holmgren, Per ^b   Druid, Henrik ^c  

^a LINKÖPING UNIVERSITY   (Sweden)

^b DEPARTMENT OF FORENSIC GENETICS AND FORENSIC TOXICOLOGY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Blood loss; Codeine; Forensic science; Forensic toxicology; Hemorrhage; Morphine; Pharmacokinetics; Postmortem; Rat; Redistribution

Indexed keywords

ALBUMIN; CODEINE; CODEINE PHOSPHATE; MORPHINE;

ALBUMIN BLOOD LEVEL; ANIMAL MODEL; BLEEDING; BLOOD ANALYSIS; BLOOD VOLUME; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; FEMALE; GAS CHROMATOGRAPHY; HEMATOCRIT; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

EID: 0038710967     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs2002356     Document Type: Conference Paper

References (18)

1. Guyton AC, Hall JE. Textbook of medical physiology. 10th Ed. New York: W. B. Saunders. 2000.
2. Chien S. Quantitative evaluation of the circulatory adjustments of splenectomized dogs to hemorrhage. Am J Physiol 1958;193:605-14.
3. Chien S. Role of the sympathetic nervous system in hemorrhage. Physiol Rev 1967;47(2):214-88.
4. De Paepe P, Belpaire FM, Rosseel MT, Buylaert WA. The influence of hemorrhagic shock on the pharmacokinetics and the analgesic effect of morphine in the rat. Fundam Clin Pharmacol 1998;12(6):624-30.
5. De Paepe P, Belpaire FM, Van Hoey G, Boon PA, Buylaert WA. Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat. J Pharmacol Exp Ther 1999;290(3):1048-53.
6. Egan TD, Kuramote S, Gong G, Zhang J, McJames SW, Bailey PL. Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model. Anesthesiology 1999;91(1):156-66.
7. Falkmer S, Waller T. Försöksdjursteknik. En praktisk handledning. Stockholm, Sweden: Almqvist & Wiksell; 1984.
8. Schuberth J, Schuberth J. Gas chromatographic-mass spectrometric determination of morphine, codeine and 6-monoacetylmorphine in blood extracted by solid phase. J Chromatogr 1989;490(2):444-9.
9. Doumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 1971;31(1):87-96.
10. Yuan J, Dunnick JK, Barnes ER, Findlay JWA. Codeine toxicokinetics in rats during a two-year dosed feed study. Drug Metab Dispos 1994;22(1):14-20.
11. Donnerer J, Cardinale G, Coffey J, Lisek CA, Jardine I, Spector S. Chemical characterization and regulation of endogenous morphine and codeine in the rat. J Pharmacol Exp Ther 1987;242(2):583-7.
12. Hilberg T, Ripel A, Slordal L, Bjorneboe A, Morland J. The extent of postmortem drug redistribution in a rat model. J Forensic Sci 1999;44:956-62.
13. Lundvall J, Hillman J. Fluid transfer from skeletal muscle to blood during hemorrhage. Importance of beta adrenergic vascular mechanisms. Acta Physiol Scand 1978;102(4):450-8.
14. Baggot JD, Davis LE. Species differences in plasma protein binding of morphine and codeine. Am J Vet Res 1973;34(4):571-4.
15. Shah J, Mason WD. Pharmacokinetics of codeine after parenteral and oral dosing in the rat. Drug Met Dispos 1990;18(5):670-3.
16. Quiding H, Andersson P, Bondesson U, Boreus LO, Hynning PA. Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration. Eur J Clin Pharmacol 1986;30(6):673-7.
17. Lundvall J, Lanne T. Large capacity in man for effective plasma volume control in hypovolaemia via fluid transfer from tissue to blood. Acta Physiol Scand 1989;137(4):513-20.
18. Brettel HF, Rogowski Weber AK, Bickel M. Animal experiments on blood alcohol curves in shock. Blutalkohol 1984;21(4):338-46.