The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration

British Journal of Ophthalmology

Volumn 87, Issue 6, 2003, Pages 753-757

  Harris, Alon ^a,b   Ciulla, T A ^c   Pratt, L M ^b   Rechtman, E ^b   Kagemann, L ^b   Piper, H C ^b   Garzozi, H J ^d  

^a IUMC   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MIDWEST EYE INSTITUTE   (United States)

^d BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DORZOLAMIDE; PLACEBO;

AGED; ARTICLE; CHOROID; CHOROID VASCULARIZATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EVALUATION; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; INDOCYANINE GREEN ANGIOGRAPHY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA BLOOD FLOW; RETINA MACULA AGE RELATED DEGENERATION; SCANNING LASER OPHTHALMOSCOPE; TIME;

AGED; ANTIHYPERTENSIVE AGENTS; CHOROID; COLORING AGENTS; DOUBLE-BLIND METHOD; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; INDOCYANINE GREEN; MACULAR DEGENERATION; MALE; MIDDLE AGED; RETINAL VESSELS; SULFONAMIDES; THIOPHENES;

EID: 0038694680     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.87.6.753     Document Type: Article

References (21)

1. Young R. Pathophysiology of age-related macular degeneration. Surv Ophthalmol 1987;31:291-306.
2. Eagle RJ. Mechanisms of maculopathy. Ophthalmology 1984;91:613-25.
3. Allikmets R, Shroyer N, Singh N, et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 1997;277:1805-7.
4. Friedman E. A hemodynamic model of the pathogenesis of age-related macular degeneration. Am J Ophthalmol 1997;124:677-82.
5. Boker T, Fang T, Steinmetz R. Refractive error and choroidal perfusion characteristics in patients with choroidal neovascularization and age-related macular degeneration. Ger J Ophthalmol 1993;2:10-13.
6. Remulla J, Gaudio A, Miller S, et al. Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Br J Ophthalmol 1995;79:558-61.
7. Zhao J, Frambach D, Lee P, et al. Delayed macular choriocapillary circulation in age-related macular degeneration. Int Ophthalmol 1995;19:1-12.
8. Chen J, Fitzke F, Pauleikhoff D, et al. Functional loss in age-related Bruch's membrane change with choroidal perfusion defect. Invest Ophthalmol Vis Sci 1992;33:334-40.
9. Pauleikhoff D, Chen J, Chisholm I, et al. Choroidal perfusion abnormality with age-related Bruch's membrane change. Am J Ophthalmol 1990;109:211-17.
10. Piguet B, Palmvang I, Chisholm I, et al. Evolution of age-related macular degeneration with choroidal perfusion abnormality. Am J Ophthalmol 1992;113:657-63.
11. Grunwald J, Hariprasad S, DuPont J, et al. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci 1998;1998:385-90.
12. Friedman E, Krupsky S, Lane A, et al. Ocular blood flow velocity in age-related macular degeneration. Ophthalmology 1995;102:640-6.
13. Ciulla T, Harris A, Chung H, et al. Color Doppler imaging reveals reduced ocular blood flow velocities in nonexudative age-related macular degeneration. Am J Ophthalmol 1998;128:75-80.
14. Mori F, Konno S, Hikichi T, et al. Pulsatile ocular blood flow study: decreases in exudative age-related macular degeneration. Br J Ophthalmol. 2001;85:531-3.
15. Bird A, Bressler N, Bressler S, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol 1995;39:367-74.
16. Harris A, Kagemann L, Chung H, et al. The use of dye dilution curve analysis in the quantification of indocyanine green angiograms of the human choroid. In: JS S, ed. Ophthalmology Clinics of North America, Ophthalmic Imaging and Diagnostics. Vol 11. Philadelphia: WB Saunders, 1998:331-7.
17. Harris A, Kagemann L, Cioffi GA. Assessment of human ocular hemodynamics. Surv Ophthalmol 1998;42:509-33.
18. Ross RD, Barofsky JM, Cohen G, et al. Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration. Am J Ophthalmol 1998;125:71-80.
19. Ciulla TA, Harris A, Kagemann L, et al. Choroidal perfusion perturbations in non-neavascular age related macular degeneration. Br J Ophthalmol 2002;86:209-13.
20. Harris A, Arend O, Arend S, et al. Effects of topical dorzolamide on retinal and retrobulbar hemodynamics. Acta Ophthalmol Scand 1996;74:569-72.
21. Harris A, Arend O, Chung HS, et al. A comparative study of betaxolol and dorzolamide effect on ocular circulation in normal-tension glaucoma patients. Ophthalmology 2000;107:430-4.