Tokishakuyakusan directly attenuates PACAP's luteolytic action on luteal function in the rat ovary

American Journal of Chinese Medicine

Volumn 30, Issue 4, 2002, Pages 521-531

  Usuki, Satoshi ^a   Kotani, Eri ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b Hasakisaisei Hospital   (Japan)

Author keywords

Corpus luteum; LH; Luteotrophic action; PACAP; Rat; Steroidogenesis; Tokishakuyakusan

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; CYCLIC AMP; GESTAGEN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; LUTEINIZING HORMONE; PROGESTERONE; TOKISHAKUYAKU SAN; ADCYAP1 PROTEIN, HUMAN; ADCYAP1 PROTEIN, RAT; CHORIONIC GONADOTROPIN; HERBACEOUS AGENT; LUTEOLYTIC AGENT; NEUROPEPTIDE; SERIC GONADOTROPIN; TOKI SHAKUYAKU SAN; TOKI-SHAKUYAKU-SAN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORPUS LUTEUM; DRUG EFFECT; DRUG INHIBITION; HORMONE SYNTHESIS; LUTEAL CELL; NONHUMAN; OVARY FUNCTION; RAT; STEROIDOGENESIS; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; EXTRACELLULAR SPACE; FEMALE; HORSE; HUMAN; METABOLISM; OVARY; WISTAR RAT;

ANIMALS; CHORIONIC GONADOTROPIN; CYCLIC AMP; DRUGS, CHINESE HERBAL; EXTRACELLULAR SPACE; FEMALE; GONADOTROPINS, EQUINE; HORSES; HUMANS; LUTEAL CELLS; LUTEINIZING HORMONE; LUTEOLYTIC AGENTS; NEUROPEPTIDES; OVARY; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROGESTERONE; PROGESTINS; RATS; RATS, WISTAR;

EID: 0038690604     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X02000545     Document Type: Article

References (16)

1. Arimura, A. Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regulat. Peplide 37: 287-303, 1992.
2. Hsueh, A.J.W., E.Y. Adashi, P.B.C. Jones and T.H. Welsh. Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr. Rev. 5: 76-127, 1984.
3. Kimura, C., S. Ohkubo, K. Ogi, M. Hosoya, Y. Itoh, H. Onda, A. Miyata, L. Jiang, R.D. Dahl, H.H. Stibbs, A. Arimura and M. Fujino. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem. Biophys. Res. Commun. 166: 81-89, 1990.
4. Kotani, E., S. Usuki and T. Kubo. Rat corpus luteum expresses both PACAP and PACAP type IA receptor mRNAs. Peptides 18: 1453-1455, 1997.
5. Kotani, E., S. Usuki and T. Kubo. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured granulosa cells from rat ovary and expression of mRNA encoding PACAP type IA receptor. J. Reprod. Steril. 112: 107-114, 1998.
6. Kotani, E., S. Usuki and T. Kubo. Pituitary adenylate cyclase-activating polypeptide, in the rat ovary. In: S. Fujimoto, E.Y. Adashi, A.J.W. Hsueh and J.F. Strauss, III (eds.) "Ovarian Function Research: Present and Future". Frontiers in Endocrinology Vol. 21, pp. 99-108, 1999.
7. Leung, P.C.K. and G.L. Steele. Intracellular signaling in the gonads. Endocr. Rev. 13: 476-498, 1992.
8. Marsh, J.M. The role of cyclic ANP in gonadal function. Adv. Cyclic Nucleotide Res. 6: 137-199, 1975.
9. Miyata, A., A. Arimura, R.R. Dahl, N. Minamino, A. Uehara, D. Jiang, M.D. Cullar and D.H. Coy. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun. 164: 567-574, 1989.
10. Miyata, A., L. Jiang, R.D. Dahl, C. Kitada, K. Kubo, M. Fujino, N. Minamino and A. Arimura. Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem. Biophys. Res. Commun. 170: 643-648, 1990.
11. Rawlings, S.R. and M. Hezareh. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal peptide receptors: actions on the anterior pituitary gland. Endocr. Rev. 17: 4-29, 1996.
12. Usuki, S. Effects of Hachimijiogan, Tokishakuyakusan and Keishibukuryogan on estrogen and progesterone secretions by rat preovulatory follicles. Am. J. Chin. Med. 14: 161-170, 1986.
13. Usuki, S. Effects of Hachimijiogan, Tokishakuyakusan and Keishibukuryogan on progesterone secretion by corpus luteum. Am. J. Chin. Med. 15: 109-115, 1987.
14. Usuki, S. Effects of herbal components of Tokishakuyakusan on progesterone secretion by corpus luteum in vitro. Am. J. Chin. Med. 19: 57-60, 1991a.
15. Usuki, S. Growth hormone stimulates ovarian progestin production by the corpus luteum. Jpn. J. Fertil. Steril. 36: 1-5, 1991b.
16. Usuki, S. and E. Kotani. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells fron rat ovary. Gynecol. Endocrinol. 15: 184-191, 2001.