A stereoselective aldol reaction via diisopinocampheyl boron-enolate in preparation of chromane carboxylate with quaternary carbon

Tetrahedron Letters

Volumn 44, Issue 28, 2003, Pages 5285-5288

  Lang, Fengrui ^a   Zewge, Daniel ^a   Song, Zhiguo J ^a   Biba, Mirlinda ^a   Dormer, Peter ^a   Tschaen, David ^a   Volante, R P ^a   Reider, Paul J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORON; BORON DERIVATIVE; CARBON; CARBOXYLIC ACID DERIVATIVE; CHLORIDE; CHROMANE CARBOXYLATE; DIISOPINOCAMPHEYLBORON ENOLATE; ESTER DERIVATIVE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; REAGENT; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOSELECTIVITY; NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STEREOISOMERISM; SYNTHESIS;

EID: 0038684476     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01220-6     Document Type: Article

References (21)

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21. 4Na (M+Na): 287.1254. Found 287.1264. 19, 14 and 15, aldol reaction of 16 gave ca. 50% yield with modest selectivity: dr=7 and 45% ee.