Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-α and construction of a novel BC-analogue by an unusual julia olefination process

Organic Letters

Volumn 5, Issue 4, 2003, Pages 499-502

  Hale, Karl J ^a,b   Frigerio, Mark ^a,b   Manaviazar, Soraya ^a,b   Hummersone, Marc G ^a,b   Fillingham, Ian J ^a,b   Barsukov, Igor G ^a,b   Damblon, Christian F ^a,b   Gescher, Andreas ^a,b   Roberts, Gordon C K ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; BRYOSTATIN; PHORBOL 13 ACETATE; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG; WATER; ANTINEOPLASTIC AGENT; BRYOSTATIN 1; LACTONE; MACROLIDE; PHORBOL 13 MONOACETATE; PHORBOL 13-MONOACETATE; PHORBOL ESTER; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C;

ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; JULIA OLEFINATION; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE; TITRIMETRY; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; HUMANS; LACTONES; MACROLIDES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP; TITRIMETRY;

EID: 0038683557     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol027392u     Document Type: Article

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