메뉴 건너뛰기




Volumn 109, Issue 5-6, 2003, Pages 259-263

Clinical and laboratory effects of recombinant human activated protein C in the treatment of a patient with sepsis-induced multiple organ failure

Author keywords

Coagulopathy; Inflammation; Intensive care medicine; Multiple organ failure; Recombinant human activated protein C; Sepsis

Indexed keywords

ACTIVATED PROTEIN C; ANTIINFECTIVE AGENT; CIPROFLOXACIN; DOPAMINE; DROTRECOGIN; ERYTHROMYCIN; HYPERTENSIVE FACTOR; NORADRENALIN; PIPERACILLIN; RECOMBINANT PROTEIN; TAZOBACTAM; VANCOMYCIN;

EID: 0038683400     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(03)00243-3     Document Type: Article
Times cited : (10)

References (18)
  • 1
    • 0025861039 scopus 로고
    • Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein C
    • Esmon C.T., Taylor F.B. Jr., Snow T.R. Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb. Haemost. 66:1991;160-165.
    • (1991) Thromb. Haemost. , vol.66 , pp. 160-165
    • Esmon, C.T.1    Taylor F.B., Jr.2    Snow, T.R.3
  • 2
    • 0025647250 scopus 로고
    • Experimental endotoxemia in humans: Analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
    • Van Deventer S.J., Buller H.R., ten Cate J.W., Aarden L.A., Hack C.E., Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood. 76:1990;2520-2526.
    • (1990) Blood , vol.76 , pp. 2520-2526
    • Van Deventer, S.J.1    Buller, H.R.2    Ten Cate, J.W.3    Aarden, L.A.4    Hack, C.E.5    Sturk, A.6
  • 3
    • 0026591793 scopus 로고
    • The protein C anticoagulant pathway
    • Esmon C.T. The protein C anticoagulant pathway. Arterioscler. Thromb. 12:1992;135-145.
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 135-145
    • Esmon, C.T.1
  • 4
  • 5
    • 0029793068 scopus 로고    scopus 로고
    • The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
    • Bajzar L., Nesheim M.E., Tracy P.B. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood. 88:1996;2093-2100.
    • (1996) Blood , vol.88 , pp. 2093-2100
    • Bajzar, L.1    Nesheim, M.E.2    Tracy, P.B.3
  • 6
    • 11944258039 scopus 로고
    • Characterization and novel purification of recombinant human protein C from three mammalian cell lines
    • Yan S.B., Razzano P., Chao Y.B., Walls J.D., Berg D.T., McClure D.B.et al. Characterization and novel purification of recombinant human protein C from three mammalian cell lines. Biotechnology (NY). 8:1990;655-661.
    • (1990) Biotechnology (NY) , vol.8 , pp. 655-661
    • Yan, S.B.1    Razzano, P.2    Chao, Y.B.3    Walls, J.D.4    Berg, D.T.5    McClure, D.B.6
  • 7
    • 0000519967 scopus 로고
    • Recombinant human protein C, protein S, and thrombomodulin as antithrombotics
    • Yan S.B., Grinnell B.W. Recombinant human protein C, protein S, and thrombomodulin as antithrombotics. Perspect. Drug Discovery Des. 1:1993;503-520.
    • (1993) Perspect. Drug Discovery Des. , vol.1 , pp. 503-520
    • Yan, S.B.1    Grinnell, B.W.2
  • 8
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • Murakami K., Okajima K., Uchiba M., Johno M., Nakagaki T., Okabe H.et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 87:1996;642-647.
    • (1996) Blood , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3    Johno, M.4    Nakagaki, T.5    Okabe, H.6
  • 9
    • 0028299926 scopus 로고
    • Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosulated oligosaccharide
    • Grinnell B.W., Hermann R.B., Yan S.B. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosulated oligosaccharide. Glycobiology. 4:1994;221-225.
    • (1994) Glycobiology , vol.4 , pp. 221-225
    • Grinnell, B.W.1    Hermann, R.B.2    Yan, S.B.3
  • 10
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester
    • Grey S.T., Tsuchida A., Hau H., Orthner C.L., Salem H.H., Hancock W.W. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J. Immunol. 153:1994;3664-3672.
    • (1994) J. Immunol. , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 11
    • 0003134388 scopus 로고    scopus 로고
    • Recombinant human activated protein C (rhAPC) improves coagulation abnormalities, morbidity and 28 day mortality in patients with severe sepsis
    • Fisher C.J., LaRosa S.P., Helterbrand J.D., Bernard G.R. Recombinant human activated protein C (rhAPC) improves coagulation abnormalities, morbidity and 28 day mortality in patients with severe sepsis. J. Antimicrob. Chemother. 44(Suppl. A):1999;10.
    • (1999) J. Antimicrob. Chemother. , vol.44 , Issue.SUPPL. A , pp. 10
    • Fisher, C.J.1    LaRosa, S.P.2    Helterbrand, J.D.3    Bernard, G.R.4
  • 12
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant activated protein C for severe sepsis
    • Bernard G.R.et al. Efficacy and safety of recombinant activated protein C for severe sepsis. N. Engl. J. Med. 344:2001;699-709.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 699-709
    • Bernard, G.R.1
  • 13
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European Society of Intensive Care Medicine
    • Vincent J.L., Moreno R., Takala J., Willats S., De Mendonca A., Bruining H.et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European Society of Intensive Care Medicine. Intensive Care Med. 22:1996;707-710.
    • (1996) Intensive Care Med. , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3    Willats, S.4    De Mendonca, A.5    Bruining, H.6
  • 15
    • 0027457502 scopus 로고
    • Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality
    • Pinsky M.R., Vincent J.L., Deviere J., Alegre M., Kahn R.J., Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest. 103:1993;565-575.
    • (1993) Chest , vol.103 , pp. 565-575
    • Pinsky, M.R.1    Vincent, J.L.2    Deviere, J.3    Alegre, M.4    Kahn, R.J.5    Dupont, E.6
  • 16
    • 0029825840 scopus 로고    scopus 로고
    • Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit
    • Friedland J.S., Porter J.C., Daryanani S., Bland J.M., Screaton N.J., Vesely M.J.et al. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit. Care Med. 24:1996;1775-1781.
    • (1996) Crit. Care Med. , vol.24 , pp. 1775-1781
    • Friedland, J.S.1    Porter, J.C.2    Daryanani, S.3    Bland, J.M.4    Screaton, N.J.5    Vesely, M.J.6
  • 18
    • 0019917301 scopus 로고
    • Studies of components of the coagulation system in normal individuals and septic shock patients
    • Smith-Erichsen N., Aasen A.O., Gallimore M.J., Amundsen E. Studies of components of the coagulation system in normal individuals and septic shock patients. Circ. Shock. 9:1982;491-497.
    • (1982) Circ. Shock , vol.9 , pp. 491-497
    • Smith-Erichsen, N.1    Aasen, A.O.2    Gallimore, M.J.3    Amundsen, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.