Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels

American Journal of Physiology - Cell Physiology

Volumn 285, Issue 1 54-1, 2003, Pages

  Boland, Linda M ^a   Jiang, Min ^b   Lee, So Yeong ^a   Fahrenkrug, Scott C ^a   Harnett, Mark T ^a   O'Grady, Scott M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Exon; Gating; Inactivation; K channel interacting protein; Mutagenesis

Indexed keywords

CELL PROTEIN; MESSENGER RNA; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL INTERACTING PROTEIN; POTASSIUM CHANNEL INTERACTING PROTEIN 1A; POTASSIUM CHANNEL INTERACTION PROTEIN 1B; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN FUNCTION; BRAIN TISSUE; CELL FUNCTION; CELL SPECIFICITY; CEREBELLUM; CHANNEL GATING; CONTROLLED STUDY; DELETION MUTANT; EXON; GENE DELETION; GENE INACTIVATION; GENETIC CONSERVATION; HEART; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

MAMMALIA;

EID: 0038679203     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00416.2002     Document Type: Article

References (36)

1. Altschul SF, Gish W, Miller W, Myers EW, and Lipman DJ. Basic local alignment search tool. J Mol Biol 215: 403-410, 1990.
2. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, and Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403: 553-556, 2000.
3. Bähring R, Boland LM, Varghese A, Gebauer M, and Pongs O. Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535: 65-81, 2001.
4. Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, and Isbrandt D. Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem 276: 23888-23894, 2001.
5. + channel. Neuron 7: 471-483, 1991.
6. Beck EJ, Bowlby M, An WF, Rhodes KJ, and Covarrubias M. Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol 538: 691-706, 2002.
7. Breathnach R and Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem 50: 349-383, 1981.
8. 2+-binding proteins. Biochem J 353: 1-12, 2001.
9. + channel currents. Eur Biophys J J.29: 555-557, 2000.
10. Connor JA and Stevens CF. Voltage clamp studies of a transient outward membrane current in gastropod neural somata. J Physiol 215: 21-30, 1971.
11. Decher N, Uyguner O, Scherer CR, Karaman B, Yuksel-Apak M, Busch AE, Steinmeyer K, and Wollnik B. hKChIP2 is a functional modifier of hKv4.3 potassium channels. Cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res 52: 255-264, 2001.
12. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 79: 659-668.
13. to,s: early after depolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 α subunit. Circ Res 87: 73-79, 2000.
14. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387: 869-875, 1997.
15. Holmqvist MH, Cao J, Knoppers MH, Jurman ME, Distefano PS, Rhodes KJ, Xie Y, and An WF. Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins. J Neurosci 21: 4154-4161, 2001.
16. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, and An WF. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci USA 99: 1035-1040, 2002.
17. Horikoshi T and Sakakibara M. Quantification of relative mRNA expression in the rat brain using simple RT-PCR and ethidium bromide staining. J Neurosci Methods 99: 4-51, 2000.
18. + channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophys J 72: 163-174, 1997.
19. Jerng HH, Shahidullah M, and Covarrubias M. Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. J Gen Physiol 113: 641-660, 1999.
20. Johns DC, Nuss HB, and Marban E. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs. J Biol Chem 272: 31598-31603, 1997.
21. Johnston D, Hoffman DA, Magee JC, Poolos NP, Watanabe S, Colbert CM, and Migliore M. Dendritic potassium channels in hippocampal pyramidal neurons. J Physiol 525: 75-81, 2000.
22. to and confers susceptibility to ventricular tachycardia. Cell 107: 801-813, 2001.
23. Magee JC and Johnston D. A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science 275: 209-213, 1997.
24. + conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7: 5-15, 1999.
25. 2+-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. FEBS Lett 499: 205-209, 2001.
26. + channel diversity in the mammalian myocardium. J Physiol 525: 285-298, 2000.
27. + channel-interacting protein 2. Biochem Biophys Res Commun 282: 96-102, 2001.
28. + channel cloned from mammalian brain. Proc Natl Acad Sci USA 88: 4386-4390, 1991.
29. Reese MG, Eeckman FH, Kulp D, and Haussler D. Improved splice site detection in Genie. J Comput Biol 4: 311-323, 1997.
30. Rosati B, Pan Z, Lype S, Wang HS, Cohen I, Dixon JE, and McKinnon D. Regulation of KChIP2 potassium channel β sub-unit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533: 119-125, 2001.
31. Schoppa NE and Westbrook GL. Regulation of synaptic timing in the olfactory bulb by an A-type potassium current. Nat Neurosci 2: 1106-1113, 1999.
32. + channels operating at subthreshold potentials with unique expression in heart and brain. J Neurophysiol 75: 2174-2179, 1996.
33. + (A-type) currents in rat brain. J Neurophysiol 79: 1081-1091, 1998.
34. + channel proteins in rat central neurons. Neuron 9:271-284, 1992.
35. Song WJ, Tkatch T, Baranauskas G, Ichinohe N, Kitai S, and Surmeier DJ. Somatodendritic depolarization-activated potassium currents in rat neostriatal cholinergic interneurons are predominantly of the A type and attributable to coexpression of Kv42 and Kv41 subunits. J Neurosci 18: 3124-3137, 1998.
36. Yeola S and Snyders DJ. Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovasc Res 33: 540-547, 1997.