Powdered cellulose as excipient for extrusion-spheronization pellets of a cohesive hydrophobic drug

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 55, Issue 3, 2003, Pages 291-295

  Alvarez, Lisardo ^a   Concheiro, Angel ^a   Gómez Amoza, José Luis ^a   Souto, Consuelo ^a   Martínez Pacheco, Ramón ^a  

^a Universidade de Santiago de Compostela   (Spain)

Author keywords

Extrusion spheronization; Furosemide; Microcrystalline cellulose; Mixer torque rheometry; Powdered cellulose

Indexed keywords

CELLULOSE; DRUG; FUROSEMIDE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG PELLET; DRUG RELEASE; HYDROPHOBICITY; PARTICLE SIZE; PELLET EXTRUSION; POWDER; SPHERONIZATION;

EID: 0038669007     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00032-8     Document Type: Article

References (16)

1. Fielden K.E., Newton J.M. Extrusion and extruders. Swarbrick J., Boylan J.C. Encyclopedia of Pharmaceutical Technology. Vol. 5:1992;395-442 Marcel Dekker, New York.
2. Pinto J.F., Buckton G., Newton J.M. The influence of four selected processing and formulation factors on the production of spheres by extrusion and spheronization. Int. J. Pharm. 83:1992;187-196.
3. Kleinebudde P. Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose: I. Shrinking properties. Int. J. Pharm. 109:1994;209-219.
4. Vervaet C., Baert L., Remon J.P. Enhancement of in vitro drug release by using polyethylene glycol 400 and PEG-40 hydrogenated castor oil pellets made by extrusion/spheronisation. Int. J. Pharm. 108:1994;207-212.
5. Millili G.P., Schwartz B. The strength of microcrystalline cellulose pellets: The effect of granulating with water-ethanol mixtures. Drug Dev. Ind. Pharm. 16:1990;1411-1426.
6. O'Connor R.E., Schwartz J.B. Drug release mechanism from a microcrystalline cellulose pellet system. Pharm. Res. 10:1993;356-361.
7. Lindner H., Kleinebudde P. Use of powdered cellulose for the production of pellets by extrusion/spheronization. J. Pharm. Pharmacol. 46:1994;2-7.
8. Ammar H.O., Ghorab M., El-Nahhas S.A., Emara L.H., Makram T.S. Inclusion of furosemide in cyclodextrins. Part I: Effect of cyclodextrins on the physicochemical characteristics of furosemide. Pharmazie. 54:1992;142-144.
9. Exner H.E., Link E. Image analysis for characterization of size and shape distribution of lead powders. Powder Metall. Int. 9:1977;131-133.
10. Instruction Manual Pores Size 9305. 1984;Micromeritics, Norcross.
11. Thomson F.M. Storage of particulate solids. Fayed M.E., Otten L. Handbook of Powder Science and Technology. 1984;365-463 Van Nostrand Reinhold, New York.
12. Khan K.A., Rhodes C.T. Effect of compaction pressure on the dissolution efficiency of some direct compression systems. Pharm. Acta Helv. 47:1972;594-607.
13. Alvarez L., Concheiro A., Gómez-Amoza J.L., Souto C., Martínez-Pacheco R. Effect of microcrystalline cellulose grade and process variables on pellets prepared by extrusion-spheronization. Drug Dev. Ind. Pharm. 28:2002;451-456.
14. El Saleh F., Jumaa M., Hassan I., Kleinebudde P. Influence of cellulose type on the properties of extruded pellets. Part II. Production and properties of pellets. STP Pharma Sci. 10:2000;379-385.
15. Carr R. Chemical Engineering. 1965;McGraw-Hill, New York.
16. Schröder M., Kleinebudde P. Influence of formulation parameters on dissolution of propyphenazone pellets. Eur. J. Pharm. Biopharm. 41:1995;382-387.