Sirolimus delays renal allograft recovery

American Journal of Transplantation

Volumn 3, Issue 4, 2003, Pages 363-365

  Davis, Connie ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BINDING PROTEIN; CALCINEURIN INHIBITOR; CYCLOSPORIN; INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; RECEPTOR BLOCKING AGENT; S6 KINASE; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CONVALESCENCE; DELAYED GRAFT FUNCTION; DIALYSIS; DISEASE ASSOCIATION; DONOR; DRUG CHOICE; DRUG EXPOSURE; DRUG USE; FIBROSING ALVEOLITIS; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; GRAFT FAILURE; HIGH RISK POPULATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY INJURY; KIDNEY TUBULE NECROSIS; MULTIVARIATE ANALYSIS; NEPHROTOXICITY; NONHUMAN; REVIEW; SODIUM EXCRETION;

ANIMALS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY TRANSPLANTATION; SIROLIMUS;

EID: 0038666506     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2003.00116.x     Document Type: Review

References (17)

1. Groth CG, Backman L, Morales JM et al. Sirolimus (Rapamycin) based therapy in human renal transplantation. Transplantation 1999; 67: 1036-1042.
2. Kahan BD, for the Rapamune US Study Group. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomized multicentre study. Lancet 2000; 356: 194-202.
3. MacDonald AS, for the Rapamune Global Study Group. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 2001; 71: 271-280.
4. Hong JC Kahan BD. Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression. Transplantation 1999; 68: 701-704.
5. Chang GJ, Mahanty HD, Vincenti F et al. A calcineurin inhibitorsparing regimen with sirolimus, mycophenolate mofetil, and anti-CD25 mAb provides effective immunosuppression in kidney transplant recipients with delayed or impaired graft function. Clin Transplant 2000; 14: 550-554.
6. Grinyo JM, Gil-Vernet S, Seron D et al. Primary immunosuppression with mycophenolate mofetil and antithymocyte globulin for kidney transplant recipients of a suboptimal graft. Nephrol Dial Transplant 1998; 13: 2601-2604.
7. Lebranchu Y, Bridoux F, Buchler M et al. Immunoprophylaxis with basiliximab compared with antithymocyte globulin in renal transplant patients receiving MMF-containing triple therapy. Am J Transplant 2002; 2: 48-56.
8. Sommer BG, Henry ML, Ferguson RM. Sequential conventional immunotherapy with maintenance cyclosporine following transplantation. Transplant Proc 1986; 18 (Suppl): 69-75.
9. Muller T, Ruffingshofer D, Bidmon B, Arbeiter K, Balzar E, Aufricht C. Reduction of delayed renal allograft function using sequential immunosuppression. Pediatr Nephrol 2001; 16: 613-617.
10. Sollinger H, Kaplan B, Pescovitz MD et al. Baxiliximab versus anti-thymocyte globulin for prevention of acute renal allograft rejection. Transplantation 2001; 72: 1915-1919.
11. Gonwa TA, Mai MI, Melton L et al. Immunosuppression for delayed or slow graft function in primary cadaveric renal transplantation: use of low dose tacrolimus therapy with postoperative administration of anti-CD-25 monoclonal antibody. Clin Transplant 2002; 16: 144-149.
12. McTaggart RA, Gottlieb D, Brooks J et al. Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation. Am J Transplant 2003; 3: 416-423.
13. Smith KD, Wrenshall LE, Nicosia RF et al. Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. J Am Soc Nephrol 2003; in press.
14. Andoh TF, Choi S-O, Wakba IM, Bennett WM. Beneficial effect of mycophenolate mofetil in sirolimus induced delayed renal function in post-ischemic rat kidney. Am J Transplant 2002; 3: 161 (Abstract).
15. Lieberthal W, Fuhro R, Andry CC, Rennke H. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol 2001; 281: F693-F706.
16. Andoh TF, Burdmann EA, Fransechini N, Houghton DC, Bennett WM. Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. Kidney Int 1996; 50: 1110-1117.
17. Qureshi F, Rabb H, Kasiske BL. Silent acute rejection during prolonged delayed graft function reduces kidney allograft survival. Transplantation 2002; 74: 1400-1404.