Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures

Epilepsia

Volumn 44, Issue 5, 2003, Pages 724-726

  Yu, Kian Ti ^a,c   Mills, Sandra ^a   Thompson, Nanora ^a   Cunanan, Cedric ^b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b ABBOTT LABORATORIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute repetitive seizures; Acute seizure; Emergencies; Intravenous valproate; Pediatric; Status epilepticus

Indexed keywords

VALPROIC ACID;

ACUTE REPETITIVE SEIZURE; ADOLESCENT; ADULT; ANTICONVULSANT THERAPY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG INFUSION; DRUG SAFETY; EPILEPTIC STATE; FEMALE; HEART RATE; HUMAN; INFANT; MALE; MENTAL HEALTH; PRIORITY JOURNAL; SEIZURE; TREMOR;

ACUTE DISEASE; ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; FEMALE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; SEIZURES; STATUS EPILEPTICUS; TREATMENT OUTCOME; VALPROIC ACID;

EID: 0038665608     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.41302.x     Document Type: Article

References (15)

1. Mitchell WG. Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. Epilepsia 1996;37(suppl 1):S74-80.
2. Nowack WJ. EEG in status epilepticus. eMedicine Web site. Available at: http://www.emedicine.com/neuro.topic114.htm. Accessed November 26, 2002.
3. Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology 1993;43:483-8.
4. Devinsky O, Leppik I, Willmore LJ, et al. Safety of intravenous valproate. Ann Neurol 1995;38:670-4.
5. Venkataraman V, Wheless JW. Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients. Epilepsy Res 1999;35:147-53.
6. Naritoku DK, Mueed S. Intravenous loading of valproate for epilepsy. Clin Neuropharmacol 1999;22:102-6.
7. Wheless J, Venkataraman V. Safety of high intravenous valproate doses in epilepsy patients. J Epilepsy 1998;11:319-24.
8. Blaise FD, Bourgeois MD. Valproate. In: Pellock JM, Dodson WE, Blaise FD, et al., eds. Pediatric epilepsy diagnosis and therapy. 2nd ed. New York: Demos, 2001:443-6.
9. Vajda FJ, Mihaly GW, Miles JL, et al. Rectal administration of sodium valproate in status epilepticus. Neurology 1978;28:897-9.
10. Thorpy MJ. Rectal valproate syrup and status epilepticus. Neurology 1980;30:1113-4.
11. Viani F, Jussi MI, Germano M, et al. Rectal administration of sodium valproate for neonatal and infantile status epilepticus. Dev Med Child Neurol 1984;26:679-99.
12. Barnes SE, Bland D, Cole AP, et al. The use of sodium valproate in a case of status epilepticus. Dev Med Child Neurol 1976;18:236-8.
13. Chez MG, Hammer MS, Loeffel M, et al. Clinical experience of three pediatric and one adult cases of spike-and-wave status epilepticus treated with injectable valproic acid. J Child Neurol 1999;14:239-42.
14. Uberall MA, Trollmann R, Wunsiedler U, et al. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology 2000;54:2188-9.
15. White JR, Santos CS. Intravenous valproate associated with significant hypotension in the treatment of status epilepticus. J Child Neurol 1999;14:822-3.