Determination of didanosine in human serum by on-line solid-phase extraction coupled to high-performance liquid chromatography with electrospray ionization tandem mass spectrometric detection: Application to a bioequivalence study

Journal of Mass Spectrometry

Volumn 38, Issue 4, 2003, Pages 378-385

  de Cassia E Estrela, Rita ^a   Salvadori, Myriam C ^a   Raices, Renata S L ^a   Suarez Kurtz, Guilherme ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

Didanosine; Lamivudine; Liquid chromatography tandem mass spectrometry; Pharmacokinetics; Solid phase extraction

Indexed keywords

ABSORPTION; BODY FLUIDS; IONIZATION; LIQUID CHROMATOGRAPHY;

HUMAN SERUM;

MASS SPECTROMETRY;

DIDANOSINE; LAMIVUDINE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; ASSAY; BIOEQUIVALENCE; CHEMICAL REACTION; CLINICAL PROTOCOL; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; MONITORING; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SERUM; SOLID PHASE EXTRACTION; STANDARD; VOLUNTEER;

ADMINISTRATION, ORAL; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDANOSINE; HUMANS; LAMIVUDINE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 0038663230     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.449     Document Type: Article

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