Multicenter prospective study of clonal complications in adult aplastic anemia patients following recombinant human granulocyte colony-stimulating factor (lenograstim) administration

International Journal of Hematology

Volumn 77, Issue 2, 2003, Pages 152-158

  Bessho, Masami ^a   Hotta, Tomomitsu ^b   Ohyashiki, Kazuma ^c   Takahashi, Takayuki ^d   Mizoguchi, Hideaki ^f   Asano, Shigetaka ^g   Ikeda, Yasuo ^h   Sakurai, Masaharu ⁱ   Tojo, Arinobu ^g   Kizaki, Masahiro ^h   Iwanaga, Masako ^e   Tomonaga, Masao ^e   Hirashima, Kunitake ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

^e NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^g UNIVERSITY OF TOKYO   (Japan)

^h KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁱ Japanese Red Cross Society   (Japan)

Author keywords

Aplastic anemia; Chromosomal abnormality; Clonal evolution; G CSF; MDS; Monosomy 7

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANDROGEN; ASPARTATE AMINOTRANSFERASE; CORTICOSTEROID; CYCLOSPORIN A; ERYTHROPOIETIN; GAMMA GLUTAMYLTRANSFERASE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1; INTERLEUKIN 3; LACTATE DEHYDROGENASE; LYMPHOCYTE ANTIBODY; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; APLASTIC ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHILD; CHROMOSOME ABERRATION; CLINICAL TRIAL; CLONE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOGENETICS; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; FEVER; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; KARYOTYPE; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MONOSOMY 7; MULTICENTER STUDY; PAPULE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; CELL CLONE; CHEMICALLY INDUCED DISORDER; CHROMOSOME 7; CHROMOSOME ANALYSIS; DRUG EFFECT; FOLLOW UP; MIDDLE AGED; MONOSOMY; MYELODYSPLASTIC SYNDROME; PATHOLOGY; TIME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, APLASTIC; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 7; CLONE CELLS; CYTOGENETIC ANALYSIS; FEMALE; FOLLOW-UP STUDIES; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HUMANS; MALE; MIDDLE AGED; MONOSOMY; MYELODYSPLASTIC SYNDROMES; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 0038651142     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. De Planque MM, Kluin-Nelemans HC, van Krieken HJM, et al. Evolution of acquired severe aplastic anemia to myelodysplasia and subsequent leukemia in adults. Br J Haematol. 1988;70:55-62.
2. Paquette RL, Tebyani N, Frane M, et al. Long-term outcome of aplastic anemia in adults treated with antithymocyte globulin: comparison with bone marrow transplantation. Blood. 1995;85:283-290.
3. De Planque MM, Bacigalupo A, Wursch A, et al. Long-term follow-up of severe aplastic anemia patients treated with antithymocyte globulin. Severe Aplastic Anemia Working Party of the European Cooperative Group for Bone Marrow Transplantation (EBMT). Br J Haematol. 1989;73:121-126.
4. Marsh JC, Hows JM, Bryett KA, et al. Survival after antilymphocyte globulin therapy for aplastic anemia depends on disease severity. Blood. 1987;70:1046-1052.
5. Tichelli A, Alois G, Catherine N, et al. Morphology in patients with severe aplastic anemia is treated with antilymphocyte globulin. Blood. 1992;80:337-345.
6. Ohara A, Kojima S, Hamajima N, et al. Increased incidence of myelodysplastic syndrome and acute myeloid leukemia in children with severe aplastic anemia treated with recombinant human granulocyte colony-stimulating factor: a survey by the aplastic anemia committee of the Japanese Society of Pediatric Hematology. Blood. 1997;90:1009-1013.
7. Kojima S, Hibi S, Kosaka Y, et al. Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia (AA). Blood. 2000;96:2049-2054.
8. Rosati R, Mick R, Xu F, et al. Refractory cytopenia with multilineage dysplasia: further characterization of an "unclassifiable" myelodysplastic syndrome. Leukemia. 1996;10:20-26.
9. Appelbaum FR, Barrall J, Storb R, et al. Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia. Exp Hematol. 1987;15:1134-1139.
10. Kaito K, Kobayashi M, Katayama T, et al. Long-term administration of G-CSF for aplastic anemia is closely related to the early evolution of monosomy 7 MDS in adults. Br J Haematol. 1998;103:297-303.
11. Bacigalupo A, Broccia G, Corda G, et al. Antilymphocyte globulin, cyclosporine, and granulocyte colony-stimulating factor in patients with acquired severe aplastic anemia (SAA): a pilot study of the EBMT SAA working party. Blood. 1995;85:1348-1353.
12. Bacigalupo A, Bruno B, Saracco P, et al. Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. Blood. 2000;95:1931-1934.
13. Kojima S, Tsuchida M, Matsuyama T. Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF. N Engl J Med. 1992;326:1294-1295.
14. Imashuku S, Hibi S, Kataoka MY, et al. Myelodysplasia and acute myeloid leukemia in case of aplastic anemia and congenital neutropenia following G-CSF administration. Br J Haematol. 1995;89:188-190.
15. Meidlinger P, Knobl P, Jager U, et al. Granulocyte colony-stimulating factor-supported combined immunosuppressive therapy (antilymphocyte globulin, cyclosporine, and methylprednisolone) in patients with aplastic anemia: tolerability, efficacy, and changes in the progenitor cell compartment. Ann Hematol. 1999;78:299-304.
16. Gluckman E, Rokicka-Milewska R, Gordon-Smith EC, et al. Results of randomized study of glycosylated rHuG-CSF, lenograsfim, in severe aplastic anemia [abstract]. Blood. 1998;92:376a.
17. Sonoda Y, Ohno Y, Fujii H, et al. Multilineage response in aplastic anemia patients following long-term administration of filgrastim (recombinant human granulocyte colony-stimulating factor). Stem Cells. 1993;11:543-554.