Fetal myocardial protection is markedly improved by reduced cardioplegic calcium content

Annals of Thoracic Surgery

Volumn 75, Issue 6, 2003, Pages 1937-1941

  Malhotra, Sunil P ^a   Thelitz, Stephan ^b   Kirk Riemer, R ^b   Mohan Reddy, V ^b   Suleman, Sam ^b   Hanley, Frank L ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; WATER;

ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CARDIOPLEGIA; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CRYSTALLOID; DESCENDING AORTA; DIASTOLE; FETUS; FETUS HEART; HEART ARREST; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE REPERFUSION; HEART PRELOAD; HEART PROTECTION; HEART STROKE VOLUME; HEART VENTRICLE; HEART VENTRICLE COMPLIANCE; HYPERCALCEMIA; HYPOCALCEMIA; ISOLATED HEART; LAMB; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SYSTOLE; WATER CONTENT;

ANIMALS; CALCIUM; CARDIOPLEGIC SOLUTIONS; DIASTOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL HEART; GESTATIONAL AGE; GLUCOSE; HOMEOSTASIS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; PREGNANCY; SHEEP; STROKE VOLUME; SYSTOLE; TROMETHAMINE; VENTRICULAR FUNCTION, LEFT;

EID: 0038651004     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(03)00032-8     Document Type: Article

References (17)

1. Harrison MR. Surgically correctable fetal disease. Am J Surg 2000;180:335-42.
2. Harrison MR, Adzick NS, Longaker MT, et al. Successful repair in utero of a fetal diaphragmatic hernia after removal of herniated viscera from the left thorax [see comments]. N Engl J Med 1990;322:1582-4.
3. Silverman NH, Golbus MS. Echocardiographic techniques for assessing normal and abnormal fetal cardiac anatomy. J Am Coll Cardiol 1985;5:20S-29S.
4. Rose V, Clark LE. Etiology of congenital heart disease. In Freedom RM, Benson LN, Smallhorn JF, eds. Neonatal heart disease. New York: Springer Verlag, 1992:3-13.
5. Allan LD, Crawford DC, Tynan MJ. Pulmonary atresia in prenatal life. J Am Coll Cardiol 1986;8:1131-6.
6. Todros T, Presbitero P, Gaglioti P, et al. Pulmonary stenosis with intact ventricular septum: documentation of development of the lesion echocardiographically during fetal life. Int J Cardiol 1988;19:355-62.
7. Friedman WF. Sympathetic innervation of the developing rabbit heart. Circ Res 1998;23:25.
8. Pegg W, Michalak M. Differentiation of sarcoplasmic reticulum during cardiac myogenesis. Am J Physiol 1987;252:H22-31.
9. Mahoney L. Maturation of calcium transport in cardiac sarcoplasmic reticulum. Pediatr Res 1998;24:639.
10. Mahdavi V, Izumo S, Nadal-Ginard B. Developmental and hormonal regulation of sarcomere myosin heavy chain gene family. Circ Res 1987;60:804-14.
11. Hanley FL. Fetal cardiac surgery. Adv Cardiac Surg 1994;5:47-74.
12. Corno AF, Bethancourt DM, Laks H, et al. Myocardial protection in the neonatal heart: a comparison of topical hypothermia and crystalloid and blood cardioplegic solutions. J Thorac Cardiovasc Surg 1987;93:163-72.
13. Pearl JM, Laks H, Drinkwater DC, et al. Normocalcemic blood or crystalloid cardioplegia provides better neonatal myocardial protection than does low-calcium cardioplegia. J Thorac Cardiovasc Surg 1993;105:201-6.
14. Bolling K, Kronon M, Allen BS, et al. Myocardial protection in normal and hypoxically stressed hearts: the superiority of hypocalcemic versus normocalcemic blood cardioplegia. J Thorac Cardiovasc Surg 1996;112:1193-201.
15. Lee J, Halloran K, Taylor J, et al. Coronary flow and myocardial metabolism in newborn lambs: effect of hypoxia and academia. Am J Physio 1973;224:1381-7.
16. Fenton KM, Heinemann MK, Hanley FL. Exclusion of the placenta during fetal cardiac bypass allows improved systemic perfusion and provides important information about the mechanism of placental injury. J Thorac Cardiovasc Surg 1993;105:502-12.
17. Sabik JF, Assad RS, Hanley FL. Prostaglandin synthesis inhibitor prevents placental dysfunction after fetal cardiac bypass. J Thorac Cardiovasc Surg 1992;103:732.