Low albumin level in the emergency department: A potential independent predictor of delayed mortality in blunt trauma

Journal of Emergency Medicine

Volumn 25, Issue 1, 2003, Pages 1-6

  Yukl, Richard L ^a,b   Bar Or, David ^a,b   Harris, Lisbeth ^a   Shapiro, Howard ^c   Winkler, James V ^b  

^a SWEDISH MEDICAL CENTER   (United States)

^b DMI BioSciences Inc   (United States)

^c Highlands Presbyterian St Luke's Podiatric Medicine and Surgery Residency Program   (United States)

Author keywords

Albumin; Blunt trauma; Hypoalbuminemia; Mortality; Outcome; Prognosis

Indexed keywords

SERUM ALBUMIN;

ADOLESCENT; ADULT; AGE; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BLUNT TRAUMA; CHILD; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; EMERGENCY TREATMENT; EMERGENCY WARD; FEMALE; GENDER; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPOALBUMINEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SCORING SYSTEM; SURVIVAL;

EID: 0038647057     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-4679(03)00105-7     Document Type: Article

References (38)

1. Young J.S., Bassam D., Cephas G.A., Brady W.J., Butler K., Pomphrey M. Interhospital versus direct scene transfer of major trauma patients in a rural trauma system. Am Surg. 64:1998;88-91.
2. Houshian S., Larsen M.S., Holm C. Missed injuries in a Level 1 trauma center. J Trauma. 52:2002;715-719.
3. Herrmann F.R., Safran C., Levkoff S.E., Minaker K.L. Serum albumin level on admission as a predictor of death, length of stay, and readmission. Arch Intern Med. 152:1992;125-130.
4. Marinella M.A., Markert R.J. Admission serum albumin level and length of hospitalization in elderly patients. South Med J. 91:1998;851-885.
5. Engleman D.T., Adams D.H., Byrne J.G., et al. Impact of body mass index and albumin on morbidity and mortality after cardiac surgery. J Thorac Cardiovasc Surg. 118:1999;866-873.
6. Kung S.P., Tang G.J., Wu C.W., Lui W.Y. Serum albumin concentration as a prognostic indicator for acute surgical patients. Zhonghua Yi Xue Za Zhi (Taipei). 62:1999;61-67.
7. Brisinda G., Maria G., Ferrante A., Civello I.M. Evaluation of prognostic factors in patients with acute pancreatitis. Hepatogastroenterology. 46:1999;1990-1997.
8. Hedström M., Gröndal L., Örtquist A., Dalen N., Ahl T. Serum albumin and deep infection in femoral neck fractures a study of 437 cases followed for one year . Int Orthop. 22:1998;182-184.
9. Schwartzbaum J.A., Lal P., Evanoff W., et al. Presurgical serum albumin levels predict survival time from glioblastoma multiforme. J Neurooncol. 43:1999;35-41.
10. Curry S., Mandelkow H., Brick P., Franks N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 5:1998;827-835.
11. Peters T. All about Albumin biochemistry, genetics, and medical applications . 1996;Academic Press, San Diego, CA.
12. Halliwell B. Albumin - an important extracellular antioxidant? Biochem Pharmacol. 37:1988;569-571.
13. Wayner D.D., Burton G.W., Ingold K.U., Locke S. Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation. The important contribution made by plasma proteins. FEBS Lett. 187:1985;33-37.
14. Breslow NE, Day NE. Statistical methods in cancer research: volume 1 - the analysis of case/control studies. Switzerland: International Agency for Research on Cancer; 1980:164-6.
15. Hosmer D, Lemeshow S. Applied logistic regression. New York: John Wiley and Sons; 1989:82-190.
16. McClain C.J., Hennig B., Ott L.G., Goldblum S., Young A.B. Mechanisms and implications of hypoalbuminemia in head-injured patients. J Neurosurg. 69:1988;386-392.
17. Phillips A., Shaper A.G., Whincup P.H. Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes. Lancet. 2:1989;1434-1436.
18. Fleck A., Raines G., Hawker F., et al. Increased vascular permeability a major cause of hypoalbuminaemia in disease and injury . Lancet. 1:1985;781-784.
19. Soeters P.B., von Meyenfeldt M.F., Meijerink W.J., Fredrix E.W., Wouters E.F., Schols A.M. Serum albumin and mortality. (letter) Lancet. 335:1990;348.
20. Sganga G., Siegel J.H., Brown G., et al. Repriorization of hepatic plasma protein release in trauma and sepsis. Arch Surg. 120:1985;187-199.
21. Grimble R. Serum albumin and mortality. (letter) Lancet. 335:1990;350.
22. Hiyama D.T., von Allmen D., Rosenblum L., Ogle C.K., Hasselgren P.O., Fischer J.E. Synthesis of albumin and acute-phase proteins in perfused liver after burn injury in rats. J Burn Care Rehabil. 12:1991;1-6.
23. Yeun J.Y., Kaysen G.A. Factors influencing serum albumin in dialysis patients. Am J Kidney Dis. 32:1998;S118-125.
24. Kaysen G.A. Inflammation nutritional state and outcome in end stage renal disease. Miner Electrolyte Metab. 25:1999;242-250.
25. Rady M.Y., Ryan T., Starr N.J. Clinical characteristics of preoperative hypoalbuminemia predict outcome of cardiovascular surgery. JPEN J Parenter Enteral Nutr. 21:1997;81-90.
26. Yeun J.Y., Kaysen G.A. Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients. Am J Kidney Dis. 30:1997;923-927.
27. Royall J.A., Berkow R.L., Beckman J.S., Cunningham M.K., Matalon S., Freeman B.A. Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability. Am J Physiol. 257:1989;L399-410.
28. Buttenschoen K., Buttenschoen D.C., Berger D., et al. Endotoxemia and acute-phase proteins in major abdominal surgery. Am J Surg. 181:2001;36-43.
29. Buttenschoen K., Fleischmann W., Haupt U., Kinzl L., Buttenschoen D.C. Translocation of endotoxin and acute-phase proteins in malleolar fractures. J Trauma. 48:2000;241-245.
30. Bergmann P., Kacenelenbogen R., Vizet A. Plasma clearance, tissue distribution and catabolism of cationized albumins with increasing isoelectric points in the rat. Clin Sci (Lond). 67:1984;35-43.
31. Line B.R., Herrmannsdoerfer A.J., Battles A.H., Weber P.B., Dansereau R.N., Blumenstock F.A. Premortem biodistribution of radioactivity in the rat measurement of blood and tissue activity of tracers used in clinical imaging studies . Lab Anim Sci. 44:1994;495-502.
32. Marx G., Chevion M. Site-specific modification of albumin by free radicals. Biochem J. 236:1985;397-400.
33. Davies K.J., Goldberg A.L. Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells. J Biol Chem. 262:1987;8227-8234.
34. Fujino T., Kojima M., Beppu M., Kikugawa K., Yasuda H., Takahashi K. Identification of the cleavage sites of oxidized protein that are susceptible to oxidized protein hydrolase (OPH) in the primary and tertiary structures of the protein. J Biochem. 127:2000;1087-1093.
35. Davies K.J. Protein damage and degradation by oxygen radicals. 1. General aspects. J Biol Chem. 262:1987;9895-9901.
36. Dahn M.S., Jacobs L.A., Smith S., Lange M.P., Mitchell R.A., Kirkpatrick J.R. The significance of hypoallbuminemia following injury and infection. Am Surg. 51:1985;340-343.
37. Davies K.J., Goldberg A.L. Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes. J Biol Chem. 262:1987;8220-8226.
38. Demetriades D., Sava J., Alo K., et al. Old age as a criterion for trauma team activation. J Trauma. 51:2001;754-756.