Glycoprotein IIb/IIIa complex is the target in mirtazapine-induced immune thrombocytopenia

Blood Cells, Molecules, and Diseases

Volumn 30, Issue 3, 2003, Pages 241-245

  Liu, Xiaojing ^a   Sahud, Mervyn A ^a,b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b Summitt Medical Center   (United States)

Author keywords

Drug induced; Flow cytometry; Glycoprotein IIb IIIa complex; Immune thrombocytopenia; Immunoprecipitation; MAIPA; Mirtazapine (Remeron)

Indexed keywords

AUTOANTIBODY; CHROMIUM 51; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB IX COMPLEX; MIRTAZAPINE; MONOCLONAL ANTIBODY; RHESUS D ANTIBODY; THROMBOCYTE ANTIBODY; THROMBOCYTE ANTIGEN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

AGED; ANALYTIC METHOD; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; BLEEDING; BLOOD ANALYSIS; CASE REPORT; CLINICAL FEATURE; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNE THROMBOCYTOPENIA; IMMUNOASSAY; IMMUNOPRECIPITATION; MALE; PETECHIA; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPHERESIS;

EID: 0038638918     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-9796(03)00037-8     Document Type: Article

References (14)

1. Greinacher A., Eichler P., Lubenow N., Keifel V. Drug-induced and drug-dependent immune thrombocytopenias. Rev. Clin. Exp. Hematol. 5:2001;166-200.
2. Aster R.H. Drug-induced thrombocytopenia. Michelson A.D. Platelets, Chap. 40. 2002;593-606 Academic Press, San Diego.
3. Nutt D.J. Tolerability and safety aspects of mirtazapine. Hum. Psychopharmacol. 17:2002;S37-S41.
4. Oyyesanmi O., Kunkel E.J.S., Monti D.A., Field H.L. Hematologic side effects of psychotropics. Psychosomatics. 40:1999;414-421.
5. Curtis B.R., McFarland J.G., Wu G.G., Visentin G.P., Aster R.H. Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood. 84:1994;176-183.
6. 51Cr platelet lysis test documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole . Am. J. Hematol. 2:1977;65-72.
7. Bougie D., Aster R. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood. 97:2001;3846-3850.
8. Gentilini G., Curtis B.R., Aster R.H. An antibody from a patient with ranitidine-induced thrombocytopenia recognizes a site on glycoprotein IX that is a favored target for drug-induced antibodies. Blood. 92:1998;2359-2365.
9. Kiefel V. The MAIPA assay and its applications in immunohaematology. Transfus. Med. 2:1992;181-188.
10. Burgess J.K., Lopez J.A., Gaudry L.E., Chong B.H. Rifampicin-dependent antibodies bind a similar or identical epitope to glycoprotein IX-specific quinine-dependent antibodies. Blood. 95:2000;1988-1992.
11. McFarland J.G. Laboratory investigation of drug-induced immune thrombocytopenias. Transfus. Med. Rev. 7:1993;275-287.
12. Christie D.J., Sauro S.C., Cavanaugh A.L., Kaplan M.E. Severe thrombocytopenia in an acquired immunodeficiency syndrome patient associated with pentamidine-dependent antibodies specific for glycoprotein IIb/IIIa. Blood. 82:1993;3075-3080.
13. El-Kassar N., Kalfon P., Fromont P., Vezinet C., Godeau B., Duedari N., Bierling P. Fusidic acid induced acute immunologic thrombocytopenia. Br. J. Haematol. 93:1996;427-431.
14. Kunicki T.J., Russell N., Nurden A.T., Aster R.H., Caen J.P. Further studies of the human platelet receptor for quinine and quinidine-dependent antibodies. J. Immunol. 126:1981;398-402.