Addition of inhaled fluticasone propionate to systemic immunosuppression after lung transplantation: Cushing's syndrome in patients on itraconazole comedication [2]

Transplantation

Volumn 76, Issue 1, 2003, Pages 263-264

  Schmid, Christoph ^a   Naef, Rahel ^a   Speich, Rudolf ^a   Boehler, Annette ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CYCLOSPORIN; CYTOCHROME P450 3A4; DEXAMETHASONE; FLUTICASONE PROPIONATE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCOPROTEIN P; HYDROCORTISONE; ITRACONAZOLE; METHYLPREDNISOLONE; PRASTERONE; PRASTERONE SULFATE; PREDNISOLONE; PREDNISONE;

ADULT; BRONCHIOLITIS; CASE REPORT; CAUSE OF DEATH; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; CUSHING SYNDROME; DNA POLYMORPHISM; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG METABOLISM; DRUG WITHDRAWAL; FEMALE; HORMONE METABOLISM; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; IMMUNOSUPPRESSIVE TREATMENT; LETTER; LUNG TRANSPLANTATION; MALE; PRIORITY JOURNAL;

EID: 0038638354     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000071004.64164.14     Document Type: Letter

References (5)

1. Estenne M, Hertz MI. Bronchiolitis obliterans after human lung transplantation. Am J Respir Crit Care Med 2002; 166: 440.
2. Whitford H, Walters EH, Levvey B, et al. Addition of inhaled corticosteroids to systemic immunosuppression after lung transplantation: a double-blind, placebo-controlled trial. Transplantation 2002; 73: 1793.
3. Naef R, Minder S, Hofer M, et al. Increased systemic levels of inhaled fluticasone in lung transplant recipients with itraconazole comedication. Am J Resp Crit Care Med 2002; 165: A391.
4. Varis T, Kivisto KT, Backman JT, et al. The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect. Clin Pharmacol Ther 2000; 68: 487.
5. Lebrun-Vignes B, Archer VC, Diquet B, et al. Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects. Br J Clin Pharmacol 2001; 51: 443.