A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin™) in mild Alzheimer's disease patients

Life Sciences

Volumn 73, Issue 5, 2003, Pages 539-553

  Grundman, M ^a   Capparelli, E ^b   Kim, H T ^a   Morris, J C ^c   Farlow, M ^d   Rubin, E H ^c   Heidebrink, J ^e   Hake, A ^d   Ho, G ^a   Schultz, A N ^a   Schafer, K ^a   Houston, W ^a   Thomas, R ^a   Thal, L J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

AIT 082; Alzheimer's disease; Clinical trial; Neotrofin; Pharmacokinetics

Indexed keywords

LETEPRINIM; NEUROTROPHIC FACTOR; PLACEBO; PURINE DERIVATIVE;

ADULT; AGED; ALZHEIMER DISEASE; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE CALCULATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDICATION; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MALE; MEMORY; MULTICENTER STUDY; NEUROLOGIC DISEASE; NEUROPSYCHOLOGICAL TEST; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; TIME;

EID: 0038631907     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00320-5     Document Type: Article

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