Outcome of coma in children

Current Opinion in Pediatrics

Volumn 15, Issue 3, 2003, Pages 283-287

  Trübel, Hubert K ^a   Novotny, Edward ^a   Lister, George ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHILD; CHILDHOOD MORTALITY; COMA; DISEASE COURSE; ELECTROENCEPHALOGRAM; EVOKED RESPONSE; HUMAN; HYPOXIA; ISCHEMIA; MORBIDITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COMA; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT; OUTCOME ASSESSMENT (HEALTH CARE); PREDICTIVE VALUE OF TESTS;

EID: 0038628931     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-200306000-00010     Document Type: Review

References (58)

1. Wong CP, Forsyth RJ, Kelly TP, et al.: Incidence, etiology, and outcome of non-traumatic coma: a population based study. Arch Dis Child 2001, 84:193-199. This is a population-based study from northern England of children, 1 month to 12 years of age, who suffered coma following a variety of causes. Detailed data are provided regarding outcome in 278 patients.
2. Michaud LJ, Rivara FP, Grady MS, et al.: Predictors of survival and severity of disability after severe brain injury in children. Neurosurgery 1992, 31:254-264.
3. Plum F, Posner JB: The diagnosis of stupor and coma, 3rd ed. Philadelphia: FA Davis, 1980. This text is the recognized standard for the definitions and physical signs of a patient with altered consciousness.
4. Ashwal S, Cranford R: The minimally conscious state in children. Semin Pediatr Neurol 2002, 9:19-34.
5. Strauss DJ, Ashwal S, Day SM, et al.: Life expectancy of children in vegetative and minimally conscious states. Pediatr Neurol 2000, 23:312-319.
6. Waxman K, Sundine MJ, Young RF: Is early prediction of outcome in severe head injury possible? Arch Surg 1991, 126:1237-1241; discussion 1242.
7. Levy DE, Caronna JJ, Binger BH, et al.: Predicting outcome from hypoxic-ischemic coma. JAMA 1985, 253:1420-1426. This is a landmark study that examines the findings from repetitive examination to predict come outcome in adults with hypoxic-ischemic injury.
8. Levy DE, Bates D, Caronna JJ, et al.: Prognosis in nontraumatic coma. Ann Intern Med 1981, 94:293-301.
9. Edgren E, Hedstrand U, Kelsey S, et al.: Assessment of neurologic prognosis in comatose survivors of cardiac arrest. BRCT I Study Group. Lancet 1994, 343:1055-1059.
10. Hamel MB, Goldman L, Teno J, et al.: Identification of comatose patients at high risk for death or severe disability. SUPPORT Investigators. Understand Prognoses and Preferences for Outcomes and Risks of Treatments. JAMA 1995, 273:1842-1848.
11. Pifferi S, Codazzi D, Savioli M, et al.: Early prediction of neurologic prognosis after post-anoxic coma. Intensive Care Med 1998, 24:535-536.
12. Fang JF, Chen RJ, Lin BC, et al.: Prognosis in presumptive hypoxic J schemic coma in nonneurologic trauma. J Trauma 1999, 47:1122-1125.
13. Zandbergen EG, de Haan RJ, Koelman JH, et al.: Prediction of poor outcome in anoxic-ischemic coma. J Clin Neurophysiol 2000, 17:498-501.
14. Jacinto SJ, Gieron-Korthals M, Ferreira JA: Predicting outcome in hypoxic-ischemic brain injury. Pediatr Clin North Am 2001,48:647-660. This is a summary of neurologic outcome in children with hypoxic-ischemic injury, but does not include some of the most recent data.
15. Bratton SL, Jardine DS, Morray JP: Serial neurologic examinations after near drowning and outcome. Arch Pediatr Adolesc Med 1994, 148:167-170.
16. Kaplan PW, Genoud D, Ho TW, et al.: Etiology, neurologic correlations, and prognosis in alpha coma. Clin Neurophysiol 1999, 110:205-213.
17. Young GB: The EEG in coma. J Clin Neurophysiol 2000, 17:473-485.
18. Guerit JM, Fischer C, Facco E, et al.: Standards of clinical practice of EEG and EPs in comatose and other unresponsive states. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl 1999, 52:117-131.
19. Shewmon DA: Coma prognosis in children. Part I: definitional and methodological challenges. J Clin Neurophysiol 2000, 17:457-466.
20. Zandbergen EG, de Haan RJ, Stoutenbeek CP, et al.: Systematic review of early prediction of poor outcome in anoxic-ischemic coma. Lancet 1998, 352:1808-1812. This meta-analysis that assesses the value of physical findings, EEG, or SEP, as early predictors for outcome from coma in patients more than 10 years of age who have had an hypoxic-ischemic event.
21. Janati A, Erba G: Electroencephalographic correlates of near-drowning encephalopathy in children. Electroencephalogr Clin Neurophysiol 1982, 53:182-191.
22. Pressler RM, Boylan GB, Morton M, et al.: Early serial EEG in hypoxic ischemic encephalopathy. Clin Neurophysiol 2001, 112:31-37.
23. Tharp BR, Scher MS, Clancy RR: Serial EEGs in normal and abnormal infants with birth weights less than 1200 g-a prospective study with long term follow-up. Neuropediatrics 1989, 20:64-72.
24. Mandel R, Martinot A, Delepoulle F, et al.: Prediction of outcome after hypoxic-ischemic encephalopathy: a prospective clinical and electrophysiologic study. J Pediatr 2002, 141:45-50. A detailed, prospective study of 57 children evaluated immediately after an hypoxicischemic event using repetitive physical examination, EEG, and SEP. It provides valuable information about the positive and negative predictive accuracy, sensitivity, and specificity of the findings in relation to functional outcome.
25. Ruiz-Garcia M, Gonzalez-Astiazaran A, Collado-Corona MA, et al.: Brain death in children: clinical, neurophysiologic and radioisotopic angiography findings in 125 patients. Childs Nerv Syst 2000, 16:40-45; discussion 46.
26. Bell AH, McClure BG, Hicks EM: Power spectral analysis of the EEG of term infants following birth asphyxia. Dev Med Child Neurol 1990, 32:990-998.
27. Rosow C, Manberg PJ: Bispectral index monitoring. Anesthesiol Clin North Am 2001, 19:947-966, xi.
28. Carter BG, Butt W: Review of the use of somatosensory evoked potentials in the prediction of outcome after severe brain injury. Crit Care Med 2001, 29:178-186.
29. Wohlrab G, Boltshauser E, Schmitt B: Neurological outcome in comatose children with bilateral loss of cortical somatosensory evoked potentials. Neuropediattics 2001,32:271-274.
30. Frank LM, Furgiuele TL, Etheridge Jr JE: Prediction of chronic vegetative state in children using evoked potentials. Neurology 1985, 35:931-934.
31. Beca J, Cox PN, Taylor MJ, et al.: Somatosensory evoked potentials for prediction of outcome in acute severe brain injury. J Pediatr 1995, 126:44-49.
32. Goodwin SR, Friedman WA, Bellefleur M: Is it time to use evoked potentials to predict outcome in comatose children and adults? Crit Care Med 1991, 19:518-524.
33. Fiser DH: Assessing the outcome of pediatric intensive care. J Pediatr 1992, 121:68-74.
34. Chen R, Bolton CF, Young B: Prediction of outcome in patients with anoxic coma: a clinical and electrophysiologic study. Crit Care Med 1996, 24:672-678.
35. Sinson G, Bagley LJ, Cecil KM, et al.: Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury. AJNR Am J Neuroradiol 2001, 22:143-151.
36. Ross BD, Ernst T, Kreis R, et al.: 1H MRS in acute traumatic brain injury. J Magn Reson Imaging 1998, 8:829-840.
37. Falini A, Barkovich AJ, Calabrese G, et al.: Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study. AJNR Am J Neuroradiol 1998, 19:648-652.
38. Ashwal S, et al.: Proton magnetic resonance spectroscopy in the evaluation of children with congenital heart disease and acute central nervous system injury. J Thorac Cardiovasc Surg 1996, 112:403-414.
39. Ashwal S, Holshouser BA, Tomasi LG, et al.: 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurologic outcomes in children with central nervous system disease. Ann Neurol 1997, 41:470-481.
40. Auld KL, Ashwal S, Holshoulser BA, et al.: Proton magnetic resonance spectroscopy in children with acute central nervous system injury. Pediatr Neurol 1995, 12:323-334.
41. Garde K, Mortensen AC, Toft PB, et al.: Phosphorous and proton spectroscopy in relation to near incarceration and incarceration of the human brain. Acta Radiol 1994, 35:197-200.
42. Gupta RK, Saraswat VA, Poptani H, et al.: Magnetic resonance imaging and localized in vivo proton spectroscopy in patients with fulminant hepatic failure. Am J Gastroenterol 1993, 88:670-674.
43. Aichner F, Felber S, Birbamer G, et al.: Magnetic resonance: a noninvasive approach to metabolism, circulation, and morphology in human brain death. Ann Neurol 1992, 32:507-511.
44. Condon B, Oluoch-Olunya D, Hadley D, et al.: Early 1H magnetic resonance spectroscopy of acute head injury: four cases. J Neurotrauma 1998, 15:563-571.
45. Vigneron DB, Barkovich AJ, Noworolski SM, et al.: Three-dimensional proton MR spectroscopic imaging of premature and term neonates. AJNR Am J Neuroradiol 2001, 22:1424-1433.
46. Nelson S, Graves E, Pirzkall A, et al.: In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging 2002, 16:464-476.
47. Hope P, Reynolds E: NMR to measure brain pH [Letter]. Lancet 1984, 2:292.
48. Range M, Lenkinski RE, Alves WM, et al.: Brain pH in head injury: an image-guided 31P magnetic resonance spectroscopy study. Ann Neurol 1990, 28:661-667.
49. Kate T, Tokumaru A, O'Uchi T, et al.: Assessment of brain death in children by means of P-31 MR spectroscopy: preliminary note. Work in progress. Radiology 1991, 179:95-99.
50. Brooke NS, Ouwerkerk R, Adams CB, et al.: Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage. Proc Natl Acad Sci U S A 1994, 91:1903-1907.
51. Hetherington HP, Spencer DD, Vaughan JT, et al.: Quantitative (31)P spectroscopic imaging of human brain at 4 Tesla: assessment of gray and white matter differences of phosphocreatine and ATP. Magn Reson Med 2001, 45:46-52.
52. Dubowitz DJ, Bluml S, Arcinue E, et al.: MR of hypoxic encephalopathy in children after near drowning: correlation with quantitative proton MR spectroscopy and clinical outcome. AJNR Am J Neuroradiol 1998, 19:1617-1627.
53. Christophe C, Fonteyne C, Ziereisen F, et al.: Value of MR imaging of the brain in children with hypoxic coma. AJNR Am J Neuroradiol 2002, 23:716-723.
54. Firsching R, et al.: Classification of severe head injury based on magnetic resonance imaging. Acta Neurochir (Wien) 2001, 143:263-271.
55. Rutherford M, Pennock J, Schwieso J, et al.: Hypoxic-ischemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed 1996, 75:F145-F151.
56. Nakahara M, Ericson K, Bellander BM: Diffusion-weighted MR and apparent diffusion coefficient in the evaluation of severe brain injury. Acta Radiol 2001, 42:365-369.
57. Soul JS, Robertson RL, Tzika AA, et al.: Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics 2001, 108:1211-1214.
58. Phillips MD, Zimmerman RA: Diffusion imaging in pediatric hypoxic ischemia injury. Neuroimaging Clin N Am 1999, 9:41-52.