Efficacy and Tolerability of an Intraoral Benzocaine Patch in the Relief of Spontaneous Toothache Pain

Journal of Clinical Dentistry

Volumn 14, Issue 1, 2003, Pages 1-6

  Hersh, Elliot V ^a   DeRossi, Scott S ^a   Ciarrocca, Katharine N ^a   Secreto, Stacey A ^a   Ghassemi, Annahita ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Church & Dwight Co   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOCAINE; LOCAL ANESTHETIC AGENT; PLACEBO;

ADULT; AGED; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MONITORING; DRUG TOLERANCE; EMERGENCY TREATMENT; FEMALE; GINGIVA; HEADACHE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MOUTH MUCOSA; MULTIVARIATE ANALYSIS OF COVARIANCE; PAIN ASSESSMENT; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIAL; RECORDING; SENSORY DYSFUNCTION; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SURVIVAL; SYMPTOM; TOOTH PAIN; ADOLESCENT; ANALYSIS OF VARIANCE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; TIME; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; BENZOCAINE; DOUBLE-BLIND METHOD; FEMALE; GINGIVA; HEADACHE; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PLACEBOS; SURVIVAL ANALYSIS; TIME FACTORS; TOOTHACHE; TREATMENT OUTCOME;

EID: 0038622062     PISSN: 08958831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Gangarosa LP, Ciarlone AE, Neaverth EJ, Johnston CA, Snowden JD, Thompson WO: Use of verbal descriptors, thermal scores and electrical pulp testing as predictors of tooth pain before and after application of benzocaine gels into cavities of teeth with pulpitis. Anesth Prog 36:272-275, 1989.
2. Fed Reg 47(101):22712-22759, 1982.
3. Fed Reg 56(185):48302-48347, 1991.
4. Sveen OB, Yakel M, Adair SM: Efficacy of using benzocaine for temporary relief of toothache. Oral Surg 53:574-576, 1982.
5. Forbes JA: Oral Surgery. In: Advances in Pain Research and Therapy: The Design of Analgesic Clinical Trials, Vol 18, Max MB, Portenoy RK, Laska EM, eds., Raven Press, New York, pp. 347-374, 1991.
6. Hersh EV, Cooper SA, Segal H, Lamp C, Greene J: Analgesic onset time as a measure of topical anesthetic efficacy in spontaneous toothache pain: A pilot study. J Clin Dent 4:52-54, 1993.
7. Desjardins PJ, Black P, Milles M, Madirossian G, Norris L, McCauley E: A comparison of methods to measure onset of analgesia. Clin Pharmacol Ther 53:172, 1993.
8. Hersh EV, Levin LM, Cooper SA, Doyle G, Waksman J, Wedell D, Hong D, Secreto SA: Ibuprofen liquigel for oral surgery pain. Clin Ther 22:1306-1318, 2000.
9. Hersh EV, Houpt MI, Cooper SA, Feldman RS, Wolff MS, Levin LM: Analgesic efficacy and safety of an intraoral lidocaine patch. JADA 127:1626-1634, 1996.
10. Houpt MI, Heins P, Lamster I, Stone C, Wolff MS: An evaluation of intraoral lidocaine patches in reducing needle-insertion pain. Compend Cont Educ Dent 18:309-316, 1997.
11. Hersh EV, Moore PA, Ross GL: Over-the-counter analgesics and antipyretics: A critical assessment. Clin Ther 22:500-548, 2000.
12. Olson NZ, Otero AM, Marrero I, Tirado S, Cooper S, Doyle G, Jayawardena S, Sunshine A: Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. J Clin Pharmacol 41:1238-1247, 2001.
13. Gimbel JS, Brugger A, Zhao W, Verburg KM, Geis GS: Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults. Clin Ther 23:228-241, 2001.
14. Cooper SA, Reynolds DC, Reynolds B, Hersh EV: Analgesic efficacy and safety of (R) - ketoprofen in postoperative dental pain. J Clin Pharmacol 38:11S-18S, 1998.
15. Hersh EV, Cooper SA, Levin LM, Betts NJ, Wedell D, Lamp C, Wadjula J: A dose-ranging study of bromfenac sodium in oral surgery pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:36-41, 1998.
16. Kiersch TA, Halladay SC, Koschik M: A double-blind, randomized study of naproxen sodium, ibuprofen, and placebo in postoperative dental pain. Clin Ther 15:845-854, 1993.
17. Littman GS, Walker BR, Schneider BE: Reassessment of verbal and visual analog ratings in analgesic studies. Clin Pharmacol Ther 38:16-23, 1985.
18. Yagiela JA. Local anesthetics. In: Pharmacology and Therapeutics in Dentistry, Ed 4, Yagiela JA, Neidle EA, Dowd FJ, eds., Mosby, St. Louis, pp. 217-234, 1997.
19. Sessle BJ: Physiology of the trigeminal system. In: Trigeminal Neuralgia: Current Concepts Regarding Pathogenesis and Treatment, Fromm GH, Sessle BJ, eds., Butterworth-Heinemann, Boston, pp. 71-96, 1991.
20. Hersh EV: Mechanisms of pain. In: Clinical Management of Temporomandibular Disorders and Orofacial Pain, Pertes RA, Gross SG, eds., Quintessence Publishing Inc., Chicago, pp. 35-44, 1995.
21. Cooper SA: Single-dose analgesic studies: The upside and downside of assay sensitivity. In: Advances in Pain Research and Therapy: The Design of Analgesic Clinical Trials, Vol 18, Max MB, Portenoy RK, Laska EM, eds., Raven Press, New York, pp.117-125, 1991.