Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene

Endocrine Journal

Volumn 50, Issue 3, 2003, Pages 309-318

  Honda, Soichi ^a   Tanaka Kosugi, Chisato ^c   Yamada, Shozo ^d   Sano, Toshiaki ^b   Matsumoto, Toshio ^a   Itakura, Mitsuo ^c   Yoshimoto, Katsuhiko ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d TORANOMON HOSPITAL   (Japan)

Author keywords

CDK4; Loss of heterozygosity; Mutations; Pituitary adenomas; RB1

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; GENOMIC DNA; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CDK4 GENE; CHROMOSOME 13Q; CLINICAL ARTICLE; FEMALE; GENE; GENE ACTIVATION; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MALE; PROMOTER REGION; RB1 GENE; TUMOR SUPPRESSOR GENE;

ADENOMA; ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 13; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RETINOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS;

EID: 0038608891     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.50.309     Document Type: Article

References (29)

1. Adams PD (2001) Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta 1471: M123-M133.
2. , Hibberts NA, Simpson DJ, Bicknell JE, Broome JC, Hoban PR, Clayton RN, Farrell WE (1999) Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors. Clin Cancer Res 5: 2133-2139.
3. Woloschak M, Yu A, Post KD (1997) Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinog 19: 221-224.
4. Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP, Weinberg RA (1990) Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87: 2775-2779.
5. Ikeda H, Beauchamp RL, Yoshimoto T, Yandell DW (1995) Detection of heterozygous mutation in the retinoblastoma gene in a human pituitary adenoma using PCR-SSCP analysis and direct sequencing. Endocrine Pathol 6: 189-196.
6. Cryns VL, Alexander JM, Klibanski A, Arnold A (1993) The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab 77: 644-646.
7. Woloschak M, Roberts JL, Post KD (1994) Loss of heterozygosity at the retinoblastoma gene locus in human pituitary tumors. Cancer 74: 693-696.
8. Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG, Black PM (1994) Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab 78: 922-927.
9. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D (1995) Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumour suppressor other than RB. Cancer Res 55: 1613-1616.
10. Bates AS, Farrell WE, Bicknell EJ, McNicol AM, Talbot AJ, Broome JC, Perrett CW, Thakker RV, Clayton RN (1997) Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J Clin Endocrinol Metab 82: 818-824.
11. Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Buschenfelde KHMZ, Beach D (1995) A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T-lymphocytes in a human melanoma. Science 269: 1281-1284.
12. Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ, Hayward N, Dracopoli NC (1996) Germline mutations in the p16 (INK4a) binding domain of CDK4 in familial melanoma. Nature Genet 12: 97-99.
13. Tanaka C, Kimura T, Yang P, Moritani M, Yamaoka T, Yamada S, Sano T, Yoshimoto K, Itakura M (1998) Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas. J Clin Endocrinol Metab 83: 2631-2634.
14. INK4B genes in human pituitary adenomas. Eur J Endocrinol 136: 74-80.
15. Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. J Clin Endocrinol Metab 82: 3141-3147.
16. Geradts J, Kratzke RA (1996) Wild type and mutant retinoblastoma protein in paraffin sections. Mod Pathol 9: 339-347.
17. http://www.ncbi.nlm.nih.gov/genome/sts/
18. Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE (2000) Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 60: 1211-1216.
19. Sachse R, Murakami Y, Shiraishi M, Hayashi K, Sekiya T (1994) DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung. Oncogene 9: 39-47.
20. Fan X, Paetau A, Aalto Y, Valimaki M, Sane T, Poranen A, Castresana JS, Knuutila S (2001) Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas. Cancer Genet Cytogenet 128: 97-103.
21. Bishop AJR, Schiestl RH (2001) Homologous recombination as a mechanism of carcinogenesis. Biochem Biophys Acta 1471: M109-M121.
22. Sakai T, Ohtani N, McGee TL, Robbins PD, Dryja TP (1991) Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene. Nature 353: 83-86.
23. Bookstein R, Rio P, Madreperla SA, Hong F, Allred C, Grizzle WE, Lee WH (1990) Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Proc Natl Acad Sci USA 87: 7762-7766.
24. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa J-P (1998) Alteration in DNA methylation: a fundamental aspect of neoplasia. In: Woude GFV, Kleine G (eds) Advances in Cancer Research, Academic Press, Inc., San Diego, vol 72: 141-196.
25. Ohtani-Fujita N, Fujita T, Aoike A, Osifchin NE, Robbins PD, Sakai T (1993) CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8: 1063-1067.
26. Greger V, Debus N, Lohmann D, Hopping W, Passarge E, Horsthemke B (1994) Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Hum Genet 94: 491-496.
27. Sotillo R, Dubus P, Martin J, de la Cueva E, Ortega S, Malumbres M, Barbacid M (2001) Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to 1NK4 inhibitors. EMBO J 20: 6637-6647.
28. Rane SG, Cosenza SC, Mettus RV, Reddy EP (2002) Germ line transmission of the Cdk4 (R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol Cell Biol 22: 644-656.
29. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 359: 295-300.