Castration decreases amylase release associated with muscarinic acetylcholine receptor downregulation in rat parotid gland

British Journal of Pharmacology

Volumn 139, Issue 2, 2003, Pages 399-407

  Busch, Lucila ^a   Borda, Enri ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Amylase; Binding assays; Carbachol; Castration; Inositol phosphates; Parotid gland

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; AMYLASE; BENZOQUINONIUM; CARBACHOL; INOSITOL PHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; OTENZEPAD; PHOSPHATIDYLINOSITIDE; PIRENZEPINE; RECEPTOR SUBTYPE; TESTOSTERONE; TROPICAMIDE;

AMYLASE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOACCUMULATION; CASTRATION; CONTROLLED STUDY; DOWN REGULATION; HORMONE SUBSTITUTION; INHIBITION KINETICS; MALE; NONHUMAN; PAROTID GLAND; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; TISSUE SLICE;

AMYLASES; ANIMALS; BINDING, COMPETITIVE; CARBACHOL; CHOLINERGIC AGONISTS; DOWN-REGULATION; INOSITOL PHOSPHATES; MALE; ORCHIECTOMY; PAROTID GLAND; PIPERIDINES; PIRENZEPINE; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC;

EID: 0038605876     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705260     Document Type: Article

References (20)

1. BACMAN, S., STERIN-BORDA, L., CAMUSSO, J.J., ARANA, R., HUBSCHER, O. & BORDA, E. (1996). Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's Syndrome. Clin. Exp. Immunol., 104, 454-459.
2. BERNFELD, P. (1951). Enzymes of starch degradation and synthesis. Adv Enzymol., 12, 379-428.
3. BERRIDGE, M.J., DOWENS, C.P. & HAULEY, MR. (1982). Lithium amplifies agonist-dependent phosphatidyl inositol responses in brain and salivary glands. Biochem. J., 206, 587-595.
4. BROOKS, J.C., BROOKS, M., PISKOROWSKI, J. & WATSON, J.D. (1995). Amylase secretion by cultured porcine parotid cells. Arch. Oral Biol., 40, 425-432.
5. BUSCH, L., WALD, M. & BORDA, E. (2000). Influence of castration on the response of the rat vas deferens to fluoxetine. Pharmacol. Res., 42, 305-311.
6. G-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptors antagonists. Circ. Res., 72, 387-395.
7. 3 muscarinic receptors in rat parotid gland couple to two second messenger systems. Am. J. Physiol., 261, C1063-C1073.
8. FOX, P.C. (1989). Saliva composition and its importance in dental health. Compend. Cont. Educ. Dent. (Suppl)., 13, S456-S460.
9. HERRERA, J.L., LYONS, II M.F. & JOHNSON, L.F. (1988). Saliva: its roles in health and disease. J. Clin. Gastroenterol., 10, 569-578.
10. HOKIN-NEAVERSON, M. & SADEGHIAN, K. (1976). Separation of 3H-inositol monophosphates and 3H-inositol on silica gel glass-fiber sheets. J. Chromatogr., 120, 502-505.
11. 2+ mobilization in rat parotid acinar cells. J. Biol. Chem., 263, 12454-12460.
12. KATO, M., OHKUMA, S., KATAOKA, K., KASHIMA, K. & KURIYAMA K. (1992). Characterization of muscarinic receptor subtypes on rat pancreatic acini: pharmacological identification by secretory responses and binding studies. Digestion, 52, 194-203.
13. PEREZ LEIROS, C., ROSIGNOLI, F., GENARO, A.M., SALES, M.E., STERIN-BORDA, L. & BORDA, E.S. (2000). Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands. J. Auton. Nerv. Sys., 79, 99-107.
14. PRABIR, K.DE. (1996). Sex-hormonal regulation of 20.5 and 24kDa mayor male-specific proteins in Syrian hamster submandibular gland. J. Steroid Biochem. Mol. Biol., 58, 183-187.
15. ROSIGNOLI, F. & PEREZ LEIROS, C. (2002). Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland. Eur. J. Pharmacol., 439, 27-33.
16. ROSINSKI-CHUPIN, I. & ROUGEON, F. (1990). A new member of the glutamine-rich protein gene family is characterized by the absence of internal repeats and the androgen control of its expression in the submandiblular gland of rats. J. Biol. Chem., 265, 10709-10713.
17. SCHMID, S.W., MODLIN, I.M., TANG, L.H., STOCH, A., RHEE, S., NATHANSON, M.H., SCHEELE, G.A. & GORELICK, F.S. (1998). Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. Am. J. Physiol., 274, 734-741.
18. STERIN-BORDA, L., VILA ECHAGÜE, A., PEREZ LEIROS, C., GENARO, A. & BORDA, E. (1995). Endogenous nitric oxide signalling system and the cardiac muscarinic acetylcholine receptor-inotropic response. Br. J. Pharmacol., 115, 1525-1531.
19. WATSON, E.L., ABEL, P.W., DIJULIO, D., ZENG, W., MAKOID, M., JACOBSON, K.L., POTTER, L.T. & DOWD, F.J. (1996). Identification of muscarinic receptor subtypes in mouse parotid gland. Am. J. Physiol., 271, C905-C913.
20. YAMAMOTO, H., SIMS, N.E., MACAULEY, S.P., NGUYEN, K.T., NAKAGAWA, Y. & HUMPHREYS-BEHER, M.G. (1996). Alterations in the secretory response of non-obese diabetic (NOD) mice to muscarinic receptor stimulation. Clin. Immunol. Immunopathol., 78, 245-255.