Specificity of S′1 and S′2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: The importance of P′1 and P′2 positions in design of inhibitors

Biochemical Journal

Volumn 371, Issue 3, 2003, Pages 1021-1025

  Pimenta, Daniel C ^a   Fogaça, Sandro E ^a   Melo, Robson L ^a   Juliano, Luiz ^a   Juliano, Maria A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bradykinin; Inflammation; Kallidin; Kininogen; Serine protease

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; SUBSTRATES;

COMPETITIVE INHIBITION CONSTANT;

TISSUE;

BRADYKININ; ETHYLENEDIAMINE DERIVATIVE; KALLIKREIN; KALLIKREIN INHIBITOR; KALLISTATIN; KININOGEN; PEPTIDE; PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; SERINE PROTEINASE INHIBITOR; TISSUE KALLIKREIN; TISSUE KALLIKREIN BINDING PROTEIN; TISSUE KALLIKREIN-BINDING PROTEIN;

ARTICLE; CHEMICAL BINDING; FLUORESCENCE; HUMAN; HUMAN TISSUE; HYDROLYSIS; KINETICS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SOLID STATE; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM;

AMINO ACID SEQUENCE; CARRIER PROTEINS; HUMANS; KINETICS; SERPINS; TISSUE KALLIKREINS;

EID: 0038583863     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021952     Document Type: Article

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