Effects of nasal saline spray on human neutrophils

Archives of Otolaryngology - Head and Neck Surgery

Volumn 129, Issue 6, 2003, Pages 660-664

  Boston, Mark ^a,c   Dobratz, Eric J ^a   Buescher, E Stephen ^b   Darrow, David H ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b CENTER FOR PEDIATRIC RESEARCH   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; CORTICOSTEROID; DECONGESTIVE AGENT; LACTATE DEHYDROGENASE; PHOSPHATE; SODIUM CHLORIDE; TRYPAN BLUE;

ADULT; ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL VIABILITY; CILIARY MOTILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; HUMAN; MEASUREMENT; MICROSCOPY; MORPHOLOGY; MOUTH MUCOSA; NEUTROPHIL; NORMAL HUMAN; RESPIRATORY TRACT MUCOSA; RHINITIS; SINUSITIS;

ADMINISTRATION, INTRANASAL; BENZALKONIUM COMPOUNDS; CELL SURVIVAL; HUMANS; L-LACTATE DEHYDROGENASE; NEUTROPHILS; PRESERVATIVES, PHARMACEUTICAL; PROSPECTIVE STUDIES; RHINITIS; SINUSITIS; SODIUM CHLORIDE;

EID: 0038580677     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.129.6.660     Document Type: Article

References (12)

1. Håkansson B, Forsgren A, Tegner H, Toremalm NG. Inhibitory effects of nasal drops components on granulocyte chemotaxis. Pharmacol Toxicol. 1989;64:321-323.
2. Håkansson B, Linder C, Ohlsson K, Tegner H, Toremalm N. The inhibition of granulocyte phagocytosis by various components of nasal drops. Pharmacol Toxicol. 1989;65:89-91.
3. Bjerknes R, Steinsvåg SK. Inhibition of human neutrophil actin polymerization, phagocytosis and oxidative burst by components of decongestive nosedrops. Pharmacol Toxicol. 1993;73:41-45.
4. Steinsvåg SK, Bjerknes R, Berg OH. Effects of topical nasal steroids on human respiratory mucosa and human granulocytes in vitro. Acta Otolaryngol (Stockh). 1996;116:868-875.
5. Bernstein IL. Is the use of benzalkonium chloride as a preservative for nasal formulation a safety concern? a cautionary note based on compromised mucociliary activity. J Allergy Clin Immunol. 2000;105:39-44.
6. Graf P, Hallen H. Effect on the nasal mucosa of long-term treatment with oxymetazoline, benzalkonium chloride, and placebo nasal sprays. Laryngoscope. 1996; 106:605-609.
7. Ainge G, Bowles JAK, McCormick SG, Richards DH, Scales MDC. Lack of deleterious effects of corticosteroid sprays containing benzalkonium chloride on nasal ciliated epithelium: in vivo results in laboratory animals. Drug Invest. 1994; 8:127-133.
8. Braat JP, Ainge G, Bowles JA, et al. The lack of effect of benzalkonium chloride on the cilia of the nasal mucosa in patients with perennial allergic rhinitis: a combined functional, light, scanning and transmission electron microscopy study. Clin Exp Allergy. 1995;25:957-965.
9. McMahon C, Darby Y, Ryan R, Scadding G. Immediate and short-term effects of benzalkonium chloride on the human nasal mucosa in vivo. Clin Otolaryngol. 1997; 22:318-322.
10. Storaas T, Andersson M, Persson CGA, Steinsvåg SK, Marko-Varga G, Greiff L. Effects of benzalkonium chloride on innate immunity physiology of the human nasal mucosa in vivo. Laryngoscope. 2000;110:1543-1547.
11. Tomooka LT, Murphy C, Davidson TM. Clinical study and literature review of nasal irrigation. Laryngoscope. 2000;110:1189-1193.
12. Cho J, Kwun Y, Jang H, Kang J, Won Y, Yoon H. Long-term use of preservatives on rat nasal respiratory mucosa: effects of benzalkonium chloride and potassium sorbate. Laryngoscope. 2000;110:312-317.