Generation of tumors in transgenic mice expressing the SV40 T antigen under the control of ovarian-specific promoter 1

Journal of the Society for Gynecologic Investigation

Volumn 10, Issue 4, 2003, Pages 244-250

  Garson, Kenneth ^b   Macdonald, Elizabeth ^b   Dubé, Manon ^b   Bao, Rudi ^b   Hamilton, Thomas C ^b   Vanderhyden, Barbara C ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

^b NONE

Author keywords

Granulosa tumor; OSP 1 promoter; Ovarian cancer; Ovary; Transgenic

Indexed keywords

BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; EMBRYO; ENZYME ASSAY; EPITHELIUM CELL; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GRANULOSA CELL; GRANULOSA CELL TUMOR; IMMUNOHISTOCHEMISTRY; LACZ GENE; MOLECULAR CLONING; MOUSE; NONHUMAN; OVARIAN SPECIFIC PROMOTER 1 GENE; OVARY; PRIORITY JOURNAL; REPORTER GENE; SIMIAN VIRUS 40; STAINING; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, VIRAL, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; LAC OPERON; MALE; MICE; MICE, TRANSGENIC; NUCLEIC ACID HYBRIDIZATION; OVARIAN NEOPLASMS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIMIAN VIRUS 40; TRANSCRIPTION, GENETIC;

EID: 0038578821     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(03)00073-X     Document Type: Article

References (12)

1. Ong A., Maines-Bandiera S.L., Roskelley C.D., Auersperg N. An ovarian adenocarcinoma line derived from SV40/E-cadherin-transfected normal human ovarian surface epithelium. Int J Cancer. 85:2000;430-437.
2. Abdollahi A., Godwin A.K., Miller P.D., et al. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res. 57:1997;2029-2034.
3. Roby K.F., Taylor C.C., Sweetwood J.P., et al. Development of a syngeneic mouse model for events related to ovarian cancer. Carcinogenesis. 21:2000;585-591.
4. Orsulic S., Li Y., Soslow R.A., Vitale-Cross L.A., Gutkind J.S., Varmus H.E. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 1:2002;53-62.
5. Kananen K., Markkula M., Rainio E., Su J.G., Hsueh A.J., Huhtaniemi I.T. Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines . Mol Endocrinol. 9:1995;616-627.
6. Dutertre M., Gouedard L., Xavier F., et al. Ovarian granulosa cell tumors express a functional membrane receptor for anti-Mullerian hormone in transgenic mice. Endocrinology. 142:2001;4040-4046.
7. Godwin A.K., Miller P.D., Getts L.A., et al. Retroviral-like sequences specifically expressed in the rat ovary detect genetic differences between normal and transformed rat ovarian surface epithelial cells. Endocrinology. 136:1995;4640-4649.
8. Selvakumaran M., Bao R., Crijns A.P., Connolly D.C., Weinstein J.K., Hamilton T.C. Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element. Cancer Res. 61:2001;1291-1295.
9. Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature. 315:1985;115-122.
10. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: A laboratory manual. 2nd ed:1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, Maine.
11. Cohen-Tannoudji M., Vandormael-Pournin S., Drezen J., Mercier P., Babinet C., Morello D. lacZ sequences prevent regulated expression of housekeeping genes. Mech Dev. 90:2000;29-39.
12. Saenz-Robles M.T., Sullivan C.S., Pipas J.M. Transforming functions of simian virus 40. Oncogene. 20:2001;7899-7907.