Nutrition in Crohn disease

Current Opinion in Gastroenterology

Volumn 19, Issue 2, 2003, Pages 148-153

  Krok, Karen L ^a   Lichtenstein, Gary R ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ANTIOXIDANT; BUTYRIC ACID; CAROTENOID; CORTICOSTEROID; GLUCOCORTICOID; LONG CHAIN TRIACYLGLYCEROL; MESALAZINE; RETINOL; SALAZOSULFAPYRIDINE; VITAMIN D;

ANOREXIA; BONE DENSITY; CELLULAR IMMUNITY; CLINICAL TRIAL; COST OF ILLNESS; CROHN DISEASE; ENERGY RESOURCE; FRACTURE; HUMAN; HUMORAL IMMUNITY; LIPID PEROXIDATION; LOW FAT DIET; MALABSORPTION; MALNUTRITION; MEDICAL ASSESSMENT; META ANALYSIS; METABOLIC DISORDER; MORBIDITY; NAUSEA; NUTRIENT UPTAKE; NUTRITION; NUTRITIONAL DEFICIENCY; NUTRITIONAL STATUS; NUTRITIONAL SUPPORT; OSTEOPOROSIS; OXIDATIVE STRESS; PATHOGENESIS; PHYSICAL EXAMINATION; PROTEIN CALORIE MALNUTRITION; PROTEIN LOSING GASTROENTEROPATHY; REMISSION; REVIEW; VITAMIN D DEFICIENCY; VOMITING; WOUND HEALING;

EID: 0038578004     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-200303000-00009     Document Type: Review

References (58)

1. Crohn BB, Ginzburg L, Oppenheimer GD: Regional ileitis: A pathologic and clinical entity. JAMA 1932, 99:1323-1329.
2. Gee MI, Grace MG, Wensel RH, et al.: Protein-energy malnutrition in gastroenterology outpatients: increased risk in Crohn disease. J Am Diet Assoc 1985, 85:1466-1474.
3. Driscoll RH, Rosenberg IH: Total parenteral nutrition in inflammatory bowel disease. Med Clin North Am 1978, 62:185-201.
4. 12, zinc, and copper status in outpatients with Crohn disease: effect of diet counseling. J Am Diet Assoc 1987, 87:28-30.
5. McClain C, Souter C, Zieve L: Zinc deficiency: a complication of Crohn disease. Gastroenterology 1980, 78:272-279.
6. Hoffbrand AV, Stewart JS, Booth CC, et al.: Folate deficiency in Crohn disease: Incidence, pathogenesis, and treatment. BMJ 1968, 2:71-75.
7. Dear KL, Compston JE, Hunter JO: Treatments for Crohn disease that minimize steroid doses are associated with a reduced risk of osteoporosis. Clin Nutr 2001, 20:541-546. This study investigated women with Crohn disease, treated with and without steroids, and demonstrates that steroids are an independent risk factor for osteoporosis. It also shows that dietary manipulation controls disease activity without increasing the risk for osteoporosis.
8. Chen CC, Schilling LS, Lyder CH: A concept analysis of malnutrition in the elderly. J Adv Nurs 2001, 36:131-142.
9. Schneeweiss B, Lochs H, Zauner C, et al.: Energy and substrate metabolism in patients with active Crohn disease. J Nutr 1999, 129:844-848.
10. Bodnar RJ, Pasternak GW, Mann PE, et al.: Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat. Cancer Res 1989, 49:6280.
11. Hellerstein MK, Meydani SN, Meydani M, et al.: Interleukin 1 induced anorexia in the rat: Influence of prostaglandins. J Clin Invest 1989, 84:228-235.
12. Tiomny E, Horwitz C, Graff E, et al.: Serum zinc and taste acuity in Tel-Aviv patients with inflammatory bowel disease. Am J Gastroenterol 1982, 77:101-104.
13. Solomons NW, Rosenberg IH, Sandstead HH, et al.: Zinc deficiency in Crohn disease. Digestion 1977, 16:87-95.
14. King CE, Toskes PP: Small intestinal bacterial overgrowth. Gastroenterology 1979, 76:1035-1055.
15. Crama-Bohbouth G, Pena AS, Biermond J: Are activity indexes helpful in assessing active intestinal inflammation in Crohn disease? Gut 1989, 30:1236-1241.
16. Detsky AS, McLaughlin JR, Baker JP, et al.: What is subjective global assessment of nutritional status? J Parenteral Enteral Nutr 1987, 11:8-13.
17. Baker JP, Detsky AS, Wesson DE, et al.: Nutritional assessment: a comparison of clinical judgment and objective measurements. N Engl J Med 1982, 306:969-972.
18. Lashner BA, Heidenreich PA, Su GL, et al.: Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A casecontrol study. Gastroenterology 1989, 97;255-259.
19. Lashner BA. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. J Cancer Res Clin Oncol 1993, 119:549-554.
20. Lashner BA, Provencher KS, Seidner DL, et al.: The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. Gastroenterology 1997, 112:29-32.
21. National Institutes of Health. Fast Facts on Osteoporosis. Available at: http:// osteo.org/docs/47.821117075.html. Accessed September 21, 2002.
22. Bernstein CN: Risk factors and prevalence of bone disease in IBD. In: Williams CN, Bursey RF, Gall DG, et al., eds: Trends in IBD Therapy. The Netherlands: Kluner Academic Publishers; 1999:147-162.
23. Bjamason I, Macpherson A, Mackintosh C, et al.: Reduced bone density in patients with inflammatory bowel disease. Gut 1997, 40:228-233.
24. Silvennoinen JA, Karttunen TJ, Niemela SE, et al.: A controlled study of bone mineral density in patients with inflammatory bowel disease. Gut 1995, 37:71-76.
25. Bernstein CN, Seeger LL, Sayre JW, et al.: Decreased bone density in inflammatory bowel disease is related to corticosteroid use and not disease diagnosis. J Bone Miner Res 1995, 10:250-256.
26. Compston JE, Judd D, Crawley EO, et al.: Osteoporosis in patients with inflammatory bowel disease. Gut 1987, 28:410-415.
27. Staun M, Tjellesen M, Thale M, et al.: Bone mineral content in patients with Crohn disease. A longitudinal study in patients with bowel resections. Scand J Gastroenterol 1997, 32:226-232.
28. Rigeaud D, Angel LA, Cerf M, et al.: Mechanisms of decreased food intake during weight loss in adult Crohn disease patients without obvious malabsorption. Am J Clin Nutr 1994, 60:775-781.
29. Felson DT, Zhang Y, Hannan MT, et al.: Effects of weight and body mass index on bone mineral density in men and women: The Framingham Study. J Bone Miner Res 1993, (Suppl):567-573.
30. Driscoll RH, Meredith SC, Sitrin M, et al.: Vitamin D deficiency and bone disease in patients with Crohn disease. Gastroenterology 1982, 83:1252-1258.
31. Scarla SH, Minne HW, Lempert UG, et al.: Bone mineral density and calcium regulating hormones in patients with inflammatory bowel diseases (Crohn disease and colitis ulcerosa). Exp Clin Endocrinol 1994, 11102:44-49.
32. Motley RJ, Clements D, Evans WD, et al.: A four-year longitudinal study of bone loss in patients with inflammatory bowel disease. Bone Miner 1993, 23:95-104.
33. Roux C, Abitbol V, Chaussade S, et al.: Bone loss in patients with inflammatory bowel disease: a prospective study. Osteoporos Int 1995, 5:104-156.
34. Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 1990, 112:352-364.
35. Koutkia P, Lu Z, Chen TC, et al.: Treatment of vitamin D deficiency due to Crohn disease with tanning bed ultraviolet B radiation. Gastroenterology 2001, 121:1485-1488. This is an interesting case report of a woman with severe Crohn disease and subsequent vitamin D deficiency who is treated with ultraviolet B radiation. Her vitamin D levels improved with time and her symptoms resolved.
36. Nielsen OH, Ahnfelt-Ronne I: Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. Klin Wochenschr 1991, 69:995-1000.
37. McKenzie SJ, Baker MS, Buffinton GD, et al.: Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J Clin Invest 1996, 98:136-141.
38. Kitahora T, Suzuki K, Asakura H: Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn disease. Dig Dis Sci 1988, 33:951-955.
39. D'Odorico A, Bortolan A, Cardin R, et al.: Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 2001, 36:1289-1294. This study, which was conducted to determine vitamin A, E, and carotenoid concentrations in patients with inflammatory bowel disease (IBD), found a depletion in these antioxidants. It also demonstrated that patients with IBD have an increase in free radical peripheral leukocyte DNA damage.
40. Wendland BE, Aghdassi E, Tam C, et al.: Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. Am J Clin Nutr 2001, 74:259-264.
41. DiMascio P, Murphy ME, Sies H: Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 1991, 53(Suppl):194S-200S.
42. Imes S, Pinchbeck B, Dinwoodie A, et al.: Vitamin A status in 137 patients with Crohn disease. Digestion 1987, 37:166-170.
43. Kuroki F, Lida M, Tominaga M, et al.: Multiple vitamin status in Crohn disease. Correlation with disease activity. Dig Dis Sci 1993, 38:1614-1618.
44. O'Morain C, Segal AW, Levi AJ: Elemental diet as primary treatment of acute Crohn disease: a controlled trial. BMJ 1984, 288:1859-1862.
45. Saverymuttu S, Hodgson HJF, Chadwick VS: Controlled trial comparing prednisolone with an elemental diet plus non absorbable antibiotics in active Crohn disease. Gut 1985, 26:994-998.
46. Giaffer MH, North G, Holdsworth CD: Controlled trial of polymeric versus elemental diet in treatment of active Crohn disease. Lancet 1990, 335:816-819.
47. Gonzalez-Huix F, de Leon R, Fernandez-Banares F, et al.: Polymeric enteral diets as primary treatment of active Crohn disease: a prospective steroid controlled trial. Gut 1993, 34:778-782.
48. Okada M, Yao T, Yamamoto T, et al.: Controlled trial comparing an elemental diet with prednisolone in the treatment of active Crohn disease. Hepatogastroenterol 1990, 37:72-80.
49. Malchow H, Steinhardt HJ, Lorenz-Meyer H, et al.: Feasibility and effectiveness of a defined-formula diet regimen in treating active Crohn disease. European Cooperative Crohn Disease Study III. Scand J Gastroenterol 1990, 25:235-244.
50. Lochs H, Steinhardt HJ, Klaus-Wentz B, et al.: Comparison of enteral nutrition and drug treatment in active Crohn disease. Gastroenterology 1991, 101:881-888.
51. Griffiths AM, Ohlsson A, Sherman PM, et al.: Meta-analysis of enteral nutrition as a primary treatment of active Crohn disease. Gastroenterology 1995, 108:1056-1067.
52. Middleton SJ, Rucker TJ, Kirby GA, et al.: Long-chain triglycerides reduce the efficacy of enteral feeds with active Crohn disease. Clin Nutr 1995, 14:229-236.
53. Evans RC, Rhodes JM: Understanding the mechanism of dietary therapy in Crohn disease-a meta-analysis of polymeric enteral feeding studies and pilot study of maintenance with low fibre/low fat diet. Gut 1996, 38:A637.
54. Leiper K, Woolner J, Mullan MMC, et al.: A randomized controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn disease. Gut 2001, 49:790-794. This study gave patients with active Crohn disease enteral feeds either high or low in long-chain triglycerides and examined their effects on inducing remission. Contrary to previous meta-analyses, no difference was seen in induction of remission between the two groups.
55. Scheppach W. Effects of short chain fatty acids on gut morphology and function. Gut 1994, 35(Suppl 1):S35-38.
56. Roediger WEW. The colonic epithelium in ulcerative colitis: an energy-deficiency disease. Lancet 1980, 2:712-715.
57. Segain JP, Raingeard de la Bletiere D, Bourreille A, et al.: Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn disease. Gut 2000, 47:397-403.
58. Targan SR, Hanauer SB, van Deventer SJ, et al.: A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn disease. Crohn Disease cA2 Study Group. N Engl J Med 1997, 337:1029-1035.