The colon mitosis-inhibitor pyroglutamyl-histidyl-glycine alters expression of immediate-early cancer-related genes in HT-29 cells

Anticancer Research

Volumn 23, Issue 2 B, 2003, Pages 1229-1234

  Reichelt, Wenche H ^a   Yndestad, Arne ^a   Wright, Marianne S ^a   Elgjo, Kjell ^a   Haug, Terje ^a   Reichelt, Karl L ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

c fos; cDNA expression array; egr 1; fosB; Gene expression; HT 29; pEHG; Peptide; PyroGlu His GlyOH; Real time PCR

Indexed keywords

PYROGLUTAMYLHISTIDYLGLYCINE;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HT29; COLON; DNA HYBRIDIZATION; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; NORTHERN BLOTTING; ONCOGENE C FOS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BACTERIAL PROTEINS; CARCINOMA; COLONIC NEOPLASMS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; GENES, IMMEDIATE-EARLY; GENES, JUN; GROWTH INHIBITORS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTESTINAL MUCOSA; MITOSIS; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PYRROLIDONECARBOXYLIC ACID; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0038577104     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Reichelt WH, Liu Y, Luna L, Eigjo K and Reichelt KL: Early oncogene mRNA expression in HT-29 cells treated with the endogenous colon mitosis inhibitor pyroglutamyl-histidyl-glycine. Anticancer Res 22: 991-6, 2002.
2. Skraastad O, Fossli T, Edminson PD and Reichelt KL: Purification and characterisation of a mitosis inhibitory tripeptide from mouse intestinal extracts. Epithelia 1: 107-19, 1987.
3. Elgjo K, Reichelt KL and Gembitky DS: Growth-inhibiting N-substituted endogenous peptides. Progress in Molecular and Subcellular Biology 20: 143-159, 1998.
4. Skraastad O and Reichelt KL: An endogenous colon mitosis inhibitor reduces proliferation of colon carcinoma cells (HT 29) in serum-restricted medium. Virchows Arch B Cell Pathol Incl Mol Pathol 56: 393-6, 1989.
5. Paulsen JE: The synthetic colon peptide pyroGlu-His-GlyOH inhibits growth of human colon carcinoma cells (HT-29) transplanted subcutaneously into athymic mice. Carcinogenesis 14: 1719-21, 1993.
6. Skraastad O and Reichelt KL: Biological characteristics of a mitotic inhibitor in the mouse colonic epithelium. Epithelia 1: 202-11, 1988.
7. Skraastad O and Reichelt KL: An endogenous colon mitosis inhibitor and dietary calcium inhibit the increased colonic cell proliferation induced by cholic acid. Scand J Gastroenterol 23: 801-7, 1988.
8. Skraastad O and Reichelt KL: An endogenous colon mitosis inhibitor reduces the increased cell proliferation in colonic epithelium induced by dietary cholic acid and treatment with 1,2-dimethylhydrazine. Carcinogenesis 10: 79-82, 1989.
9. Heid CA, Stevens J, Livak KJ and Williams PM: Real time quantitative PCR. Genome Res 6: 986-94, 1996.
10. Liu Y and Tong T: The growth-inhibiting epidermal pentapeptide, pyroGlu-Glu-Asp-Ser-GlyOH, inhibits growth and alters gene expression in non-transformed NC3H10 and transformed TC3H10 fibroblasts. Oncol Rep 6: 445-9, 1999.
11. Renan MJ: Putative repressor binding sites in the regions mediating transcriptional control of viral and cellular genes. Biosci Rep 5: 739-53, 1985.
12. Herdegen T and Leah JD: Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28: 370-490, 1998.
13. Holt JT, Gopal TV, Moulton AD and Nienhuis AW: Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci USA 83: 4794-8, 1986.
14. Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC and Milbrandt J: NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol 16: 3545-53, 1996.
15. Wu MY, Chen MH, Liang YR, Meng GZ, Yang HX and Zhuang CX: Experimental and clinicopathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma. World J Gastroenterol 7: 490-5, 2001.
16. Krishnaraju K, Hoffman B and Liebermann DA: Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood 97: 1298-305, 2001.
17. Liebermann DA and Hoffman B: MyD genes in negative growth control. Oncogene 17: 3319-29, 1998.
18. Rapp UR, Troppmair J, Beck T and Birrer MJ: Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant. Oncogene 9: 3493-8, 1994.
19. Klimpfinger M, Zisser G, Ruhri C, Putz B, Steindorfer P and Hofler H: Expression of c-myc and c-fos mRNA in colorectal carcinoma in man. Virchows Arch B Cell Pathol Incl Mol Pathol 59: 165-71, 1990.
20. Tice, DA, Soloviev I and Polakis P: Activation of the Wnt pathway interferes with serum response element- driven transcription of immediate early genes. J Biol Chem 277: 6118-23, 2002.
21. Reichelt KL, Haakonsen P, Paulsen JE, Kornstad R and Elgjo K: Difference in the distribution of low molecular weight peptides and amino acids in normal and malignant cells and tissues. Oncology Rep 1: 1107-12, 1994.
22. Kenny AJ, O'Hare MJ and Gusterson BA: Cell-surface peptidases as modulators of growth and differentiation. [Review]. Lancet 2: 785-7, 1989.
23. Tedone T, Correale M, Barbarossa G, Casavola V, Paradiso A and Reshkin SJ: Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion. Faseb J 11: 785-92, 1997.
24. Murphy G, Reynolds JJ and Hembry RM: Metalloproteinases and cancer invasion and metastasis. Int J Cancer 44: 757-60, 1989.
25. Urade M, Komatsu M, Yamaoka M, Fukasawa K, Harada M, Mima T and Matsuya T: Serum dipeptidyl peptidase activities as a possible marker of oral cancer. Cancer 64: 1274-80, 1989.
26. Rozhin J, Wade RL, Honn KV and Sloane BF: Membrane-associated cathepsin L: a role in metastasis of melanomas. Biochem Biophys Res Commun 164: 556-61, 1989.
27. Edwards DR and Murphy G: Cancer. Proteases-invasion and more. Nature 394: 527-8, 1998.
28. Lu C, Giordano FJ, Bao X, Morris KC and Rothman A: Antisense fosB RNA inhibits thrombin-induced hypertrophy in cultured pulmonary arterial smooth muscle cells. Circulation 98: 596-603, 1998.
29. Bamberger AM, Methner C, Lisboa BW, Stadtler C, Schulte HM, Loning T and Milde-Langosch K: Expression pattern of the AP-1 family in breast cancer: association of fosB expression with a well-differentiated, receptor-positive tumor phenotype. Int J Cancer 84: 533-8, 1999.
30. Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T and Utiyama H: A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. J Biochem (Tokyo) 111: 272-7, 1992.
31. Smith ER, Capo-chichi CD, He J, Smedberg JL, Yang DH, Prowse AH, Godwin AK, Hamilton TC and Xu XX: Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells. J Biol Chem 276: 47303-10, 2001.
32. Elgjo K, Reichelt KL, Clausen OP and de Angelis P: Inhibitory epidermal pentapeptide modulates proliferation and differentiation of transformed mouse epidermal cells in vitro. Virchows Arch B Cell Pathol Incl Mol Pathol 60: 161-4, 1991.
33. Jensen PK, Elgjo K, Laerum OD and Bolund L: Synthetic epidermal pentapeptide and related growth regulatory peptides inhibit proliferation and enhance differentiation in primary and regenerating cultures of human epidermal keratinocytes. J Cell Sci 97: 51-8, 1990.
34. Mercier G, Turque N and Schumacher M: Early activation of transcription factor expression in Schwann cells by progesterone. Mol Brain Res 97: 137-48, 2001.
35. Sawai H, Okazaki T, Yamamoto H, Okano H, Takeda Y, Tashima M, Sawada H, Okuma M, Ishikura H, Umehara H et al.: Requirement ofAP-1 for ceramide-induced apoptosis in human leukemia HL- 60 cells. J Biol Chem 270: 27326-31, 1995.
36. McGillis JP, Miller CN, Schneider DB, Fernandez S and Knopf M: Calcitonin gene-related peptide induces AP-1 activity by a PKA and c-fos-dependent mechanism in pre-B cells. J Neuroimmunol 123: 83-90, 2002.
37. Hodin RA, Meng S and Nguyen D: Immediate-early gene expression in EGF-stimulated intestinal epithelial cells. J Surg Res 56: 500-4, 1994.
38. Weisman AS, Tixier-Vidal A and Gourdji D: Thyrotropin-releasing hormone increases the levels of c-fos and beta-actin mRNA in GH3/B6 pituitary tumor cells. In Vitro Cell Dev Biol 23: 585-90, 1987.
39. Ouatas T, Le Mevel S, Demeneix BA and de Luze A: T3-dependent physiological regulation of transcription in the Xenopus tadpole brain studied by polyethylenimine based in vivo gene transfer. Int J Dev Biol 42: 1159-64, 1998.
40. Skraastad O: Thyrotropin-releasing hormone (TRH) inhibits cell proliferation in large bowel epithelium and epidermis. Epithelia 1: 121-8, 1987.
41. Pawlikowskl M, Zerek MG, Winczyk K, Stepien H, Lachowicz A and Janecka A: Comparison of the antiproliferative effects of colon mitosis inhibitor, thyroliberin and the somatostatin analog octreotide on rat colonic mucosal epithelial cells. Cytobios 73: 25-30, 1993.
42. Johansen PW, Paulsen RH, Björo T, Gautvik KM and Gordeladze JO: Distinct guanine nucleotide binding protein alpha-subunit receptor coupling in GH cell lines: effects of bromocriptine and hormones on effector enzyme modulation. Cell Physiol Biochem 11: 339-52, 2001.
43. Elgjo K and Reichelt KL: Beta-receptor blockade by propranolol modifies the effect of the inhibitory, endogenous epidermal pentapeptide on epidermal cell flux at the G2-M transition but not at the G1-S transition. Epithelial Cell Biol 3: 32-7, 1994.