Resolution in CCC: The effect of operating conditions and phase system properties on scale-up

Journal of Liquid Chromatography and Related Technologies

Volumn 26, Issue 9-10, 2003, Pages 1475-1491

  Sutherland, I A ^a   Hawes, D ^a   Van den Heuvel, R ^a   Janaway, L ^a   Tinnion, E ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Countercurrent chromatography; Flow rate effects; Resolution; Scaling up; Throughput; Tubing bore effects

Indexed keywords

HYDROPHOBICITY; MASS TRANSFER; MIXING; PHASE INTERFACES; THROUGHPUT; TUBING;

COUNTERCURRENT CHROMATOGRAPHY (CCC);

LIQUID CHROMATOGRAPHY;

ACETIC ACID ETHYL ESTER; HEPTANE; METHANOL; SOLVENT; WATER;

ANALYTIC METHOD; CHROMATOGRAPHY; CONFERENCE PAPER; CONTROL SYSTEM; COUNTER CURRENT CHROMATOGRAPHY; FLOW RATE; MATHEMATICAL ANALYSIS; MEASUREMENT; PHYSICAL PARAMETERS; TECHNOLOGY; VISCOSITY;

GOES;

EID: 0038575487     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120021261     Document Type: Conference Paper

References (7)

1. Wood, P.L.; Hawes, D.; Janaway, L.; Sutherland, I.A. Stationary phase retention in countercurrent chromatography: modelling the J-type centrifuge as a constant pressure drop pump. J. Liq. Chromatogr. & Rel. Technol. 2003, 26 (9&10), 1373-1396.
2. Wood, P. The Hydrodynamics of Countercurrent Chromatography in a J-Type Coil Planet Centrifuge; Brunel University, May 23, 2002; Ph.D. Thesis.
3. Sutherland, I.A.; Brown, L.; Forbes, S.; Games, D.; Hawes, D.; Hostettmann, K.; McKerrell, E.H.; Marston, A.; Wheatley, D.; Wood, P. Counter-current chromatography (CCC) and its versatile application as an industrial purification and production process. J. Liq. Chromatogr. & Rel. Technol. 1998, 21 (3), 279-298.
4. Wood, P.L.; Hawes, D.; Janaway, L.; Sutherland, I.A. The relationship between extra-coil volume and stationary phase retention in CCC using J-type centrifuges. J. Liq. Chromatogr. & Rel. Technol. 2003, 26, this issue.
5. Du, Q.; Wu, C.; Qian, G.; Wu, P.; Ito, Y. Relationship between flow-rate of the mobile phase and retention of the stationary phase in CCC. J. Chromatogr. A 1999, 835, 231-235.
6. Du, Q.Z.; Ke, C.Q.; Ito, Y. Recycling high-speed countercurrent chromatography for separation of taxol and cephalomannine. J. Liq. Chromatogr. & Rel. Technol. 1998, 21 (1 & 2), 157-162.
7. Sutherland, I.A.; de Folter, J.; Wood, P. Modelling countercurrent chromatography using an eluting countercurrent distribution model. J. Liquid Chromatogr. & Rel. Technol. 2003, 26 (9 & 10), 1449-1474.