Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles

European Journal of Pharmacology

Volumn 470, Issue 3, 2003, Pages 185-191

  Bova, Sergio ^a   Cavalli, Maurizio ^a   Cima, Lorenzo ^a   Luciani, Sisto ^a   Saponara, Simona ^b   Sgaragli, Giampietro ^b   Cargnelli, Gabriella ^a   Fusi, Fabio ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

(Rat); Ca2+ channel L type; Duodenum; Norbormide; Trachea; Urinary bladder

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CARBACHOL; IMIDE; MUSCLE RELAXANT AGENT; NORBORMIDE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT; NORBORNANE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLADDER MUSCLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DUODENUM; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; INTESTINE MUSCLE; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; STOMACH FUNDUS; TRACHEA MUSCLE; ANIMAL; DOSE RESPONSE; IN VITRO STUDY; MUSCLE RELAXATION; PHYSIOLOGY; WISTAR KYOTO RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NORBORNANES; RATS; RATS, INBRED WKY; VASOCONSTRICTOR AGENTS;

EID: 0038545278     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01797-7     Document Type: Article

References (19)

1. Ahmed F., Foster R.W., Small R.C. Some effects of nifedipine in guinea-pig isolated trachealis. Br. J. Pharmacol. 84:1985;861-869.
2. Baba K., Kawanishi M., Satake T., Tomita T. Effects of verapamil on the contractions of guinea-pig tracheal muscle induced by Ca, Sr and Ba. Br. J. Pharmacol. 84:1985;203-211.
3. Bolton T.B. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev. 59:1979;606-718.
4. Bova S., Trevisi L., Debetto P., Cima L., Furnari M., Luciani S., Padrini R., Cargnelli G. Vasorelaxant properties of norbormide, a selective vasoconstrictor agent of the rat microvasculature. Br. J. Pharmacol. 117:1996;1041-1046.
5. 2+-antagonist effects of norbormide on isolated perfused heart and cardiac myocytes of guinea-pig: a comparison with verapamil. Br. J. Pharmacol. 120:1997;19-24.
6. Bova S., Trevisi L., Cima L., Luciani S., Golovina V., Cargnelli G. Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries. J. Pharmacol. Exp. Ther. 296:2001;458-463.
7. Chang K.C., Hak J.K., Su D.C., Yoon Y.J., Kim J.H. Pharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealis. Eur. J. Pharmacol. 236:1993;51-60.
8. Cheng J.B., Townley R.G. Pharmacological characterization of effects of nifedipine on isolated guinea-pig and rat tracheal smooth muscle. Arch. Int. Pharmacodyn. 263:1983;228-244.
9. Fay F.S., Delise C.M. Contraction of isolated smooth muscle cells - structural changes. Proc. Natl. Acad. Sci. U. S. A. 70:1973;641-645.
10. 2+ current of guinea pig gastric fundus smooth muscle cells. Br. J. Pharmacol. 132:2001;1326-1332.
11. 2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes. Br. J. Pharmacol. 137:2002;323-328.
12. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:1981;85-100.
13. Isenberg G., Klockner U. Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium" Pflugers Arch. 395:1982;6-18.
14. Karaki H., Ozaki H., Hori M., Mitsui-Saito M., Amano K.I., Harada K.I., Miyamoto S., Nakazawa H., Won K.J., Sato K. Calcium movements, distribution and functions in smooth muscle. Pharmacol. Rev. 49:1997;157-230.
15. 2+ on cholinergic, KCl and phorbol ester-mediated phosphoinositide turnover and guinea pig urinary bladder contraction. Eur. J. Pharmacol. 195:1991;273-279.
16. Penner R. A practical guide to patch clamping. Sakmann B., Neher E. Single-Channel Recording. 1995;3-30 Plenum, New York, NY.
17. Roszkowski A.P. The pharmacological properties of norbormide, a selective rat toxicant. J. Pharmacol. Exp. Ther. 149:1965;288-299.
18. Roszkowski A.P., Poos G.I., Mohrbacher R.J. Selective rat toxicant. Science. 144:1964;412-413.
19. Sato K., Satake N., Shibata S., Adachi Y., Karaki H. Mechanisms of vasoinhibitory effect of cardioprotective agent, CP-060S, in rat aorta. Eur. J. Pharmacol. 400:2000;225-230.