Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: A population-based case-control study in Denmark, 1991-1994

American Journal of Epidemiology

Volumn 158, Issue 1, 2003, Pages 69-76

  Mitchell, Laura E ^a,b   Murray, Jeffrey C ^c   O'Brien, Sarah ^c   Christensen, Kaare ^d  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Case control studies; Cleft lip; Cleft palate; Genetics; Pregnancy; Receptors, retinoic acid; Vitamins

Indexed keywords

MULTIVITAMIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOL; VITAMIN;

HEALTH RISK; PREGNANCY; RISK FACTOR; VITAMIN;

ARTICLE; CASE CONTROL STUDY; CLEFT LIP; CLEFT PALATE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DENMARK; DIETARY INTAKE; DISEASE ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; LIVER; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POPULATION RESEARCH; RISK ASSESSMENT; RISK FACTOR; VITAMIN INTAKE;

CASE-CONTROL STUDIES; CLEFT LIP; CLEFT PALATE; DENMARK; DIET; DIETARY SUPPLEMENTS; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT, NEWBORN; LIVER; MALE; MATERNAL EXPOSURE; MEAT; ODDS RATIO; POLYMERASE CHAIN REACTION; PREGNANCY; RECEPTORS, RETINOIC ACID; RISK FACTORS; VARIATION (GENETICS); VITAMIN A;

DENMARK;

EID: 0038544316     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/kwg102     Document Type: Article

References (26)

1. Wyszynski DF, Beaty TH. Review of the role of potential teratogens in the origin of human nonsyndromic oral clefts. Teratology 1996;53:309-17.
2. Schutte BC, Murray JC. The many faces and factors of orofacial clefts. Hum Mol Genet 1999;8:1853-9.
3. Chenevix-Trench G, Jones K, Green A, et al. Cleft lip with or without cleft palate: associations with the transforming growth factor alpha and retinoic acid receptor loci. Am J Hum Genet 1992;51:1377-85.
4. Shaw D, Ray A, Marazita M, et al. Further evidence of a relationship between the retinoic acid receptor alpha locus and non-syndromic cleft lip with or without cleft palate. Am J Hum Genet 1993;53:1156-7.
5. Maestri NE, Beaty TH, Hetmanski JB, et al. Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. Am J Med Genet 1997;73:337-44.
6. Collins MD, Mao GE. Teratology of retinoids. Annu Rev Pharmacol Toxicol 1999;39:399-403.
7. Morriss-Kay GM, Ward SJ. Retinoids and mammalian development. Int Rev Cytol 1999;188:73-130.
8. Rothman KJ, Moore LL, Singer MR, et al. Teratogenicity of high vitamin A intake. N Engl J Med 1995;333:1369-73.
9. Martinez-Frias ML, Salvador J. Epidemiological aspects of prenatal exposure to high doses of vitamin A in Spain. Eur J Epidemiol 1990;6:118-23.
10. Shaw GM, Wasserman CR, Lammer EJ, et al. Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. Am J Hum Genet 1996;58:551-61.
11. Mills JL, Simpson JL, Cunningham GC, et al. Vitamin A and birth defects. Am J Public Health 1997;177:31-6.
12. Mastroiacovo P, Mazzone T, Aderem A, et al. High vitamin A intake in early pregnancy and major malformations: a multicenter prospective controlled study. Teratology 1999;59:7-11.
13. van den Berg H, Hulshof KF, Deslypere JP, et al. Evaluation of the effect of the use of vitamin supplements on vitamin A intake among (potentially) pregnant women in relation to the consumption of liver and liver products. Eur J Obstet Gynecol Reprod Biol 1996;66:17-21.
14. Arnhold T, Tzimas G, Wittfoht W, et al. Identification of 9-cisretinoic acid, 9, 13-di-cis-retionic acid, and 14-hydroxy-4, 14-retro-retinol in human plasma after liver consumption. Life Sci 1996;59:169-77.
15. van Vliet T, Boelsma E, de Vries AJ, et al. Retinoic acid metabolites in plasma are higher after intake of liver paste compared with a vitamin A supplement in women. J Nutr 2001;131:3197-203.
16. Christensen K, Olsen J, Nørgaard-Pedersen B, et al. Oral clefts, transforming growth factor alpha gene variants, and maternal smoking: a population-based case-control study in Denmark, 1991-1994. Am J Epidemiol 1999;149:248-55.
17. Mitchell LE, Murray JC, O'Brien S, et al. Evaluation of two putative susceptibility loci for oral clefts in the Danish population. Am J Epidemiol 2001;153:1007-15.
18. Jacobsen JS, Leth T. A vitamin in liver. Copenhagen, Denmark: The National Food Agency of Denmark, Institute of Food Safety and Nutrition, 1995. (Publication no. 8).
19. Moller R. Levnedsmiddeltabeller (The composition of food). (In Danish). Copenhagen, Denmark: Levnedmiddelstyrelsen, 1996.
20. SAS Institute, Inc. SAS software, version 8.01. Cary, NC: SAS Institute, Inc, 1999.
21. Dean AG, Dean JA, Coulombier D, et al. Epi Info, version 6.0: a word processing, database and statistics program for epidemiology on microcomputers. Atlanta, GA: Centers for Disease Control and Prevention, 1994.
22. Hosmer DW, Lemeshow S. Confidence interval estimation of interaction. Epidemiology 1992;3:452-6.
23. Itikala PR, Watkins ML, Mulinare J, et al. Maternal multivitamin use and orofacial clefts in offspring. Teratology 2001;63:79-86.
24. Mills JL. Folate and oral clefts: where do we go from here? New directions in oral clefts research. Teratology 1999;60:251-2.
25. Mitchell LE. Genetic epidemiology of birth defects: nonsyndromic cleft lip and neural tube defects. Epidemiol Rev 1997;19:61-8.
26. Vintiner GM, Lo KK, Holder SE, et al. Exclusion of candidate genes from a role in cleft lip with or without cleft palate: linkage and association studies. J Med Genet 1993;30:773-8.