The low nanomolar levels of NG-monomethylarginine in serum and urine of patients with chronic renal insufficiency are not significantly different from control levels

Amino Acids

Volumn 24, Issue 4, 2003, Pages 375-381

  Torremans, A ^a   Marescau, Bart ^a   Vanholder, R ^b   De Smet, R ^b   Billiouw, J M ^c   De Deyn, P P ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c OLV HOSPITAL   (Belgium)

Author keywords

Guanidino compounds; Methylated arginine residues; NG monomethylarginine; Nitric oxide (NO); Nitric oxide synthase (NOS); Renal insufficiency; Uraemia

Indexed keywords

CREATININE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DEVICE; FEMALE; HEMODIALYSIS PATIENT; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; UREMIA;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GUANIDINES; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; OMEGA-N-METHYLARGININE; RENAL DIALYSIS; UREMIA;

EID: 0038539450     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-002-0346-0     Document Type: Article

References (23)

1. Aiello S, Noris M, Remuzzi G (1999) Nitric oxide/L-arginine in uremia. Miner Electrolyte Metab 25: 384-390
2. Al Banchaabouchi M, Marescau B, D'Hooge R, Van Marck E, De Deyn PP (2001) Biochemical, histological and behavioral consequences of nephrectomy in young and aged mice. Nephron 89: 90-100
3. Anderstam B, Katzarski K, Bergström J (1997) Serum levels of NG,NG-dimethyl-L-arginine, a potential endogenous nitric oxide inhibitor in dialysis patients. J Am Soc Nephrol 8: 1437-1442
4. Blantz RC, Lortie M, Vallon V, Gabbai FB, Parmer RJ, Thomson S (1996) Activities of nitric oxide in normal physiology and uremia. Semin Nephrol 16: 144-150
5. Blantz RC, Satriano J, Gabbai F, Kelly C (2000) Biological effects of arginine metabolites. Acta Physiol Scand 168: 21-25
6. Bredt DS, Snyder SH (1994) Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63: 175-195
7. Ceriotti G (1971) Ultramicrodetermination of plasma urea by reaction with diacetylmonoxime antipyrine without deproteinization. Clin Chem 17: 400-402
8. MacAllister RJ, Vállance P (1998) Endogenous inhibitors of nitric oxide synthesis: how important are they? Experimental Nephrology 6: 195-199
9. MacAllister RJ, Whitley GSJ, Vallance P (1994) Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int 45: 737-742
10. MacAllister RJ, Rambousek MH, Vallance P, Williams D, Hoffmann KH, Ritz E (1996) Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure. Nephrol Dial Transplant 11: 2449-2452
11. Marescau B, Qureshi IA, De Deyn PP, Letarte J, Ryba R, Lowenthal A (1985) Guanidino compounds in plasma, urine, and cerebrospinal fluid of hyperargininemic patients during therapy. Clin Chim Acta 146: 21-27
12. Marescau B, De Deyn PP, Van Gorp L, Lowenthal A (1986) Purification procedure for some urinary guanidino compounds. J Chromat 377: 334-338
13. Marescau B, Nagels G, Possemiers I, De Broe ME, Because I, Billiouw J, Lornoy W, De Deyn PP (1997) Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism 46: 1024-1031
14. Mendes Ribeiro AC, Roberts NB, Lane C, Yaqoob M, Ellory JC (1996) Accumulation of the endogenous L-arginine analogue NG-monomethyl-L-arginine in human end-stage renal failure patients on regular haemodialysis. Exp Physiol 81: 475-481
15. Mendes Ribeiro AC, Brunini TMC, Ellory JC, Mann GE (2001) Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure. Cardiovasc Res 49: 697-712
16. Meyer J, Richter N, Hecker M (1997) High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo. Anal Biochem 247: 11-16
17. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012
18. Moncada S, Higgs A (1995) Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 9: 1319-1330
19. Noris M, Benigni A, Boccardo P, Aiello S, Gaspari F, Todeshini M, Figliuzzi M, Remuzzi G (1993) Enhanced nitric oxide synthesis in uremia: implications for platalet dysfunction and dialysis hypotension. Kidney Int 44: 445-450
20. Reyes AA, Karl IE, Klahr S (1994) Role of arginine in health and in renal disease. Am J Physiol 267: F331-F346
21. Schmidt RJ, Yokota S, Tracy TS, Sorkin MI, Baylis C (1999) Nitric oxide production is low in end-stage renal disease patients on peritoneal dialysis. Am J Physiol 276: F794-F797
22. Segarra G, Medina P, Bellester RM, Lluch P, Aldasoro M, Vila JM, Lluch S, Pelligrino DA (1999) Effects of some guanidino compounds on human cerebral arteries. Stroke 30: 2206-2210
23. Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572-575